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Body size and risk of differentiated thyroid carcinomas: Findings from the EPIC study

Rinaldi, Sabina; Lise, Mauro; Clavel-Chapelon, Francoise; Boutron-Ruault, Marie-Christine; Guillas, Gwenaelle; Overvad, Kim; Tjonneland, Anne; Halkjaer, Jytte; Lukanova, Annekatrin and Kaaks, Rudolf, et al. (2012) In International Journal of Cancer 131(6). p.1004-1014
Abstract
Results from case-control and prospective studies suggest a moderate positive association between obesity and height and differentiated thyroid carcinoma (TC). Little is known on the relationship between other measures of adiposity and differentiated TC risk. Here, we present the results of a study on body size and risk of differentiated TC based on a large European prospective study (EPIC). During follow-up, 508 incident cases of differentiated TC were identified in women, and 58 in men. 78% of cases were papillary TC. Cox proportional hazard models were used to estimate hazard ratios (HRs). In women, differentiated TC risk was significantly associated with body mass index (BMI, kg/m2) (HR highest vs lowest quintile = 1.41, 95% CI:... (More)
Results from case-control and prospective studies suggest a moderate positive association between obesity and height and differentiated thyroid carcinoma (TC). Little is known on the relationship between other measures of adiposity and differentiated TC risk. Here, we present the results of a study on body size and risk of differentiated TC based on a large European prospective study (EPIC). During follow-up, 508 incident cases of differentiated TC were identified in women, and 58 in men. 78% of cases were papillary TC. Cox proportional hazard models were used to estimate hazard ratios (HRs). In women, differentiated TC risk was significantly associated with body mass index (BMI, kg/m2) (HR highest vs lowest quintile = 1.41, 95% CI: 1.031.94); height (HR = 1.61; 95% CI: 1.182.20); HR highest vs lowest tertile waist (HR = 1.34, 95% CI: 1.001.79) and waist-to-hip ratio (HR = 1.42, 95% CI: 1.051.91). The association with BMI was somewhat stronger in women below age 50. Corresponding associations for papillary TC were similar to those for all differentiated TC. In men the only body size factors significantly associated with differentiated TC were height (non linear), and leg length (HR highest vs. lowest tertile = 3.03, 95% CI: 1.307.07). Our study lends further support to the presence of a moderate positive association between differentiated TC risk and overweight and obesity in women. The risk increase among taller individuals of both sexes suggests that some genetic characteristics or early environmental exposures may also be implicated in the etiology of differentiated TC. (Less)
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publication status
published
subject
keywords
body size, differentiated thyroid carcinoma, EPIC
in
International Journal of Cancer
volume
131
issue
6
pages
1004 - 1014
publisher
John Wiley & Sons
external identifiers
  • wos:000306735700016
  • scopus:84864131285
ISSN
0020-7136
DOI
10.1002/ijc.27601
language
English
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yes
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e642bcd7-7689-44e9-abdd-5c1e574940f7 (old id 3073509)
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2012-10-05 07:14:22
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@article{e642bcd7-7689-44e9-abdd-5c1e574940f7,
  abstract     = {Results from case-control and prospective studies suggest a moderate positive association between obesity and height and differentiated thyroid carcinoma (TC). Little is known on the relationship between other measures of adiposity and differentiated TC risk. Here, we present the results of a study on body size and risk of differentiated TC based on a large European prospective study (EPIC). During follow-up, 508 incident cases of differentiated TC were identified in women, and 58 in men. 78% of cases were papillary TC. Cox proportional hazard models were used to estimate hazard ratios (HRs). In women, differentiated TC risk was significantly associated with body mass index (BMI, kg/m2) (HR highest vs lowest quintile = 1.41, 95% CI: 1.031.94); height (HR = 1.61; 95% CI: 1.182.20); HR highest vs lowest tertile waist (HR = 1.34, 95% CI: 1.001.79) and waist-to-hip ratio (HR = 1.42, 95% CI: 1.051.91). The association with BMI was somewhat stronger in women below age 50. Corresponding associations for papillary TC were similar to those for all differentiated TC. In men the only body size factors significantly associated with differentiated TC were height (non linear), and leg length (HR highest vs. lowest tertile = 3.03, 95% CI: 1.307.07). Our study lends further support to the presence of a moderate positive association between differentiated TC risk and overweight and obesity in women. The risk increase among taller individuals of both sexes suggests that some genetic characteristics or early environmental exposures may also be implicated in the etiology of differentiated TC.},
  author       = {Rinaldi, Sabina and Lise, Mauro and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Guillas, Gwenaelle and Overvad, Kim and Tjonneland, Anne and Halkjaer, Jytte and Lukanova, Annekatrin and Kaaks, Rudolf and Bergmann, Manuela M. and Boeing, Heiner and Trichopoulou, Antonia and Zylis, Dimosthenis and Valanou, Elissavet and Palli, Domenico and Agnoli, Claudia and Tumino, Rosario and Polidoro, Silvia and Mattiello, Amalia and Bueno-de-Mesquita, H. Bas and Peeters, Petra H. and Weiderpass, Elisabete and Lund, Eiliv and Skeie, Guri and Rodriguez, Laudina and Travier, Noemie and Sanchez, Maria-Jose and Amiano, Pilar and Huerta, Jose-Maria and Ardanaz, Eva and Rasmuson, Torgny and Hallmans, Goeran and Almquist, Martin and Manjer, Jonas and Tsilidis, Konstantinos K. and Allen, Naomi E. and Khaw, Kay-Tee and Wareham, Nick and Byrnes, Graham and Romieu, Isabelle and Riboli, Elio and Franceschi, Silvia},
  issn         = {0020-7136},
  keyword      = {body size,differentiated thyroid carcinoma,EPIC},
  language     = {eng},
  number       = {6},
  pages        = {1004--1014},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Body size and risk of differentiated thyroid carcinomas: Findings from the EPIC study},
  url          = {http://dx.doi.org/10.1002/ijc.27601},
  volume       = {131},
  year         = {2012},
}