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C4b-binding protein (C4BP) activates B cells through the CD40 receptor

Brodeur, SR; Angelini, F; Bacharier, LB; Blom, Anna LU ; Mizoguchi, E; Fujiwara, H; Plebani, A; Notarangelo, LD; Dahlbäck, Björn LU and Tsitsikov, E, et al. (2003) In Immunity 18(6). p.837-848
Abstract
We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.
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Contribution to journal
publication status
published
subject
in
Immunity
volume
18
issue
6
pages
837 - 848
publisher
Cell Press
external identifiers
  • pmid:12818164
  • wos:000183767700013
  • scopus:0038503986
ISSN
1074-7613
language
English
LU publication?
yes
id
f8b64d40-ece0-4513-b242-003d3754cbaa (old id 308125)
alternative location
http://www.immunity.com/content/article/abstract?uid=PIIS1074761303001493
date added to LUP
2007-08-27 12:00:23
date last changed
2018-02-25 03:20:59
@article{f8b64d40-ece0-4513-b242-003d3754cbaa,
  abstract     = {We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.},
  author       = {Brodeur, SR and Angelini, F and Bacharier, LB and Blom, Anna and Mizoguchi, E and Fujiwara, H and Plebani, A and Notarangelo, LD and Dahlbäck, Björn and Tsitsikov, E and Geha, RS},
  issn         = {1074-7613},
  language     = {eng},
  number       = {6},
  pages        = {837--848},
  publisher    = {Cell Press},
  series       = {Immunity},
  title        = {C4b-binding protein (C4BP) activates B cells through the CD40 receptor},
  volume       = {18},
  year         = {2003},
}