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Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

Ros, Martine M.; Bueno-de-Mesquita, H. Bas; Kampman, Ellen; Aben, Katja K. H.; Buechner, Frederike L.; Jansen, Eugene H. J. M.; van Gils, Carla H.; Egevad, Lars; Overvad, Kim and Tjonneland, Anne, et al. (2012) In American Journal of Clinical Nutrition 96(4). p.902-910
Abstract
Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Design: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (alpha- and beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC,... (More)
Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Design: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (alpha- and beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity. Results: UCC risk decreased with higher concentrations of the sum of plasma carotenoids (IRR for the highest compared with the lowest quartile: 0.64; 95% CI: 0.44, 0.93; P-trend = 0.04). Plasma beta-carotene was inversely associated with aggressive UCC (IRR: 0.51; 95% CI: 0.30, 0.88; P-trend = 0.02). Plasma lutein was inversely associated with risk of nonaggressive UCC (IRR: 0.56; 95% CI: 0.32, 0.98; P-trend = 0.05). No association was observed between plasma vitamin C and risk of UCC. Conclusions: Although residual confounding by smoking or other factors cannot be excluded, higher concentrations of plasma carotenoids may reduce risk of UCC, in particular aggressive UCC. Plasma lutein may reduce risk of nonaggressive UCC. Am J Clin Nutr 2012;96:902-10. (Less)
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American Journal of Clinical Nutrition
volume
96
issue
4
pages
902 - 910
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000308977000025
  • scopus:84866635096
ISSN
1938-3207
DOI
10.3945/ajcn.111.032920
language
English
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yes
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a49c7411-033e-4d93-9078-fe0d44240a5c (old id 3189700)
date added to LUP
2012-12-03 07:09:29
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2017-07-30 04:07:24
@article{a49c7411-033e-4d93-9078-fe0d44240a5c,
  abstract     = {Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Design: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (alpha- and beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity. Results: UCC risk decreased with higher concentrations of the sum of plasma carotenoids (IRR for the highest compared with the lowest quartile: 0.64; 95% CI: 0.44, 0.93; P-trend = 0.04). Plasma beta-carotene was inversely associated with aggressive UCC (IRR: 0.51; 95% CI: 0.30, 0.88; P-trend = 0.02). Plasma lutein was inversely associated with risk of nonaggressive UCC (IRR: 0.56; 95% CI: 0.32, 0.98; P-trend = 0.05). No association was observed between plasma vitamin C and risk of UCC. Conclusions: Although residual confounding by smoking or other factors cannot be excluded, higher concentrations of plasma carotenoids may reduce risk of UCC, in particular aggressive UCC. Plasma lutein may reduce risk of nonaggressive UCC. Am J Clin Nutr 2012;96:902-10.},
  author       = {Ros, Martine M. and Bueno-de-Mesquita, H. Bas and Kampman, Ellen and Aben, Katja K. H. and Buechner, Frederike L. and Jansen, Eugene H. J. M. and van Gils, Carla H. and Egevad, Lars and Overvad, Kim and Tjonneland, Anne and Roswall, Nina and Boutron-Ruault, Marie Christine and Kvaskoff, Marina and Perquier, Florence and Kaaks, Rudolf and Chang-Claude, Jenny and Weikert, Steffen and Boeing, Heiner and Trichopoulou, Antonia and Lagiou, Pagona and Dilis, Vardis and Palli, Domenico and Pala, Valeria and Sacerdote, Carlotta and Tumino, Rosario and Panico, Salvatore and Peeters, Petra H. M. and Gram, Inger T. and Skeie, Guri and Huerta, Jose Maria and Barricarte, Aurelio and Quiros, Jose Ramon and Sanchez, Maria Jose and Buckland, Genevieve and Larranaga, Nerea and Ehrnström, Roy and Wallström, Peter and Jungberg, Boerje L. and Hallmans, Goeran and Key, Timothy J. and Allen, Naomi E. and Khaw, Kay-Tee and Wareham, Nick and Brennan, Paul and Riboli, Elio and Kiemeney, Lambertus A.},
  issn         = {1938-3207},
  language     = {eng},
  number       = {4},
  pages        = {902--910},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.3945/ajcn.111.032920},
  volume       = {96},
  year         = {2012},
}