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Even a single positive blood culture may matter- a case of prosthetic valve infective endocarditis caused by Corynebacterium kroppenstedtii

Cewers, Adam LU ; Sunnerhagen, Torgny LU orcid ; Gilje, Patrik LU ; Wannheden, Fredrik ; Bläckberg, Jonas LU ; Wierup, Per LU ; Larsson, Mårten LU and Rasmussen, Magnus LU (2024) In IDCases
Abstract
Corynebacterium is a skin commensal bacterium that can contaminate blood cultures. It is however also a rare cause of infective endocarditis (IE). Here we report a case of Corynebacterium kroppenstedtii aortic prosthesis IE in a 76-year-old man where only a single blood culture bottle was positive initially. C. kroppenstedtii is a very rare cause of IE, only reported two times previously. The diagnosis in our case was confirmed by repeated blood culture positivity and eventually by detection of DNA from C. kroppenstedtii on heart valves after valve exchange surgery. At surgery an aortic root abscess was detected and the valve was replaced by a homograft. Recovery was complicated by antibiotic-induced nephrotoxicity and treatment was... (More)
Corynebacterium is a skin commensal bacterium that can contaminate blood cultures. It is however also a rare cause of infective endocarditis (IE). Here we report a case of Corynebacterium kroppenstedtii aortic prosthesis IE in a 76-year-old man where only a single blood culture bottle was positive initially. C. kroppenstedtii is a very rare cause of IE, only reported two times previously. The diagnosis in our case was confirmed by repeated blood culture positivity and eventually by detection of DNA from C. kroppenstedtii on heart valves after valve exchange surgery. At surgery an aortic root abscess was detected and the valve was replaced by a homograft. Recovery was complicated by antibiotic-induced nephrotoxicity and treatment was concluded with moxifloxacin in combination with rifampicin. Recovery was uneventful. This case demonstrates that even a single blood culture bottle may be important in patients with prosthetic heart valves. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
IDCases
article number
e02049
publisher
Elsevier
ISSN
2214-2509
DOI
10.1016/j.idcr.2024.e02049
language
English
LU publication?
yes
id
31987258-b10b-4850-a371-daa94bc6906b
date added to LUP
2024-07-31 21:55:54
date last changed
2024-08-05 08:57:01
@article{31987258-b10b-4850-a371-daa94bc6906b,
  abstract     = {{Corynebacterium is a skin commensal bacterium that can contaminate blood cultures. It is however also a rare cause of infective endocarditis (IE). Here we report a case of Corynebacterium kroppenstedtii aortic prosthesis IE in a 76-year-old man where only a single blood culture bottle was positive initially. C. kroppenstedtii is a very rare cause of IE, only reported two times previously. The diagnosis in our case was confirmed by repeated blood culture positivity and eventually by detection of DNA from C. kroppenstedtii on heart valves after valve exchange surgery. At surgery an aortic root abscess was detected and the valve was replaced by a homograft. Recovery was complicated by antibiotic-induced nephrotoxicity and treatment was concluded with moxifloxacin in combination with rifampicin. Recovery was uneventful. This case demonstrates that even a single blood culture bottle may be important in patients with prosthetic heart valves.}},
  author       = {{Cewers, Adam and Sunnerhagen, Torgny and Gilje, Patrik and Wannheden, Fredrik and Bläckberg, Jonas and Wierup, Per and Larsson, Mårten and Rasmussen, Magnus}},
  issn         = {{2214-2509}},
  language     = {{eng}},
  month        = {{08}},
  publisher    = {{Elsevier}},
  series       = {{IDCases}},
  title        = {{Even a single positive blood culture may matter- a case of prosthetic valve infective endocarditis caused by Corynebacterium kroppenstedtii}},
  url          = {{https://lup.lub.lu.se/search/files/192374266/1-s2.0-S2214250924001252-main.pdf}},
  doi          = {{10.1016/j.idcr.2024.e02049}},
  year         = {{2024}},
}