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Mapping the intracellular fraction of water by varying the gradient pulse length in q-space diffusion MRI

Malmborg, Carin LU ; Sjöbeck, Martin LU ; Brockstedt, Sara LU ; Englund, Elisabet LU ; Söderman, Olle LU and Topgaard, Daniel LU (2006) In Journal of Magnetic Resonance 180(2). p.280-285
Abstract
Finite gradient pulse lengths are traditionally considered a nuisance in q-space diffusion NMR and MRI, since the simple Fourier relation between the acquired signal and the displacement probability is invalidated. Increasing the value of the pulse length leads to an apparently smaller value of the estimated compartment size. We propose that q-space data at different gradient pulse lengths, but with the same effective diffusion time, can be used to identify and quantify components with free or restricted diffusion from multi-exponential echo decay curves obtained on cellular systems. The method is demonstrated with experiments on excised human brain white matter and a series of model systems with well-defined free, restricted, and combined... (More)
Finite gradient pulse lengths are traditionally considered a nuisance in q-space diffusion NMR and MRI, since the simple Fourier relation between the acquired signal and the displacement probability is invalidated. Increasing the value of the pulse length leads to an apparently smaller value of the estimated compartment size. We propose that q-space data at different gradient pulse lengths, but with the same effective diffusion time, can be used to identify and quantify components with free or restricted diffusion from multi-exponential echo decay curves obtained on cellular systems. The method is demonstrated with experiments on excised human brain white matter and a series of model systems with well-defined free, restricted, and combined free and restricted diffusion behavior. Time-resolved diffusion MRI experiments are used to map the spatial distribution of the intracellular fraction in a yeast cell suspension during sedimentation, and observe the disappearance of this fraction after a heat treatment. (c) 2006 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
imaging, tissue, PGSE, pulsed field gradient, SGP
in
Journal of Magnetic Resonance
volume
180
issue
2
pages
280 - 285
publisher
Elsevier
external identifiers
  • pmid:16571376
  • wos:000237875300015
  • scopus:33646353917
ISSN
1096-0856
DOI
10.1016/j.jmr.2006.03.005
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Radiation Physics, Lund (013034000), Physical Chemistry 1 (S) (011001006), Department of Clinical Sciences, Lund (013230000)
id
33275519-dfbb-4a2c-bdb2-207cb6d543c1 (old id 408299)
date added to LUP
2016-04-01 15:22:19
date last changed
2020-01-12 18:26:38
@article{33275519-dfbb-4a2c-bdb2-207cb6d543c1,
  abstract     = {Finite gradient pulse lengths are traditionally considered a nuisance in q-space diffusion NMR and MRI, since the simple Fourier relation between the acquired signal and the displacement probability is invalidated. Increasing the value of the pulse length leads to an apparently smaller value of the estimated compartment size. We propose that q-space data at different gradient pulse lengths, but with the same effective diffusion time, can be used to identify and quantify components with free or restricted diffusion from multi-exponential echo decay curves obtained on cellular systems. The method is demonstrated with experiments on excised human brain white matter and a series of model systems with well-defined free, restricted, and combined free and restricted diffusion behavior. Time-resolved diffusion MRI experiments are used to map the spatial distribution of the intracellular fraction in a yeast cell suspension during sedimentation, and observe the disappearance of this fraction after a heat treatment. (c) 2006 Elsevier Inc. All rights reserved.},
  author       = {Malmborg, Carin and Sjöbeck, Martin and Brockstedt, Sara and Englund, Elisabet and Söderman, Olle and Topgaard, Daniel},
  issn         = {1096-0856},
  language     = {eng},
  number       = {2},
  pages        = {280--285},
  publisher    = {Elsevier},
  series       = {Journal of Magnetic Resonance},
  title        = {Mapping the intracellular fraction of water by varying the gradient pulse length in q-space diffusion MRI},
  url          = {http://dx.doi.org/10.1016/j.jmr.2006.03.005},
  doi          = {10.1016/j.jmr.2006.03.005},
  volume       = {180},
  year         = {2006},
}