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The association between changes in skin echogenicity and the fibroblast production of biglycan and versican in systemic sclerosis

Hesselstrand, Roger LU ; Westergren-Thorsson, Gunilla LU ; Scheja, Agneta LU ; Wildt, Marie LU and Åkesson, Anita LU (2002) In Clinical and Experimental Rheumatology 20(3). p.301-308
Abstract
Objective To investigate a possible association between the longitudinal changes in skin involvement and the fibroblast production of proteoglycans in vitro, among patients with early and untreated systemic sclerosis (SSc). Methods In 11 patients, 6 with diffuse cutaneous systemic sclerosis (dSSc) and 5 with limited cutaneous systemic sclerosis (lSSc), and in 6 controls skin thickness and skin echogenicity, of the forearm was measured by high frequency (20 MHz) ultrasound, A skin biopsy was taken from the area of the ultrasound measurements, and from cultivated fibroblasts the production of the proteoglycans versican, perlecan, biglycan and decorin were measured. To investigate longitudinal changes in skin involvement, the ultrasound... (More)
Objective To investigate a possible association between the longitudinal changes in skin involvement and the fibroblast production of proteoglycans in vitro, among patients with early and untreated systemic sclerosis (SSc). Methods In 11 patients, 6 with diffuse cutaneous systemic sclerosis (dSSc) and 5 with limited cutaneous systemic sclerosis (lSSc), and in 6 controls skin thickness and skin echogenicity, of the forearm was measured by high frequency (20 MHz) ultrasound, A skin biopsy was taken from the area of the ultrasound measurements, and from cultivated fibroblasts the production of the proteoglycans versican, perlecan, biglycan and decorin were measured. To investigate longitudinal changes in skin involvement, the ultrasound examination was repeated after 1-3 years. Results Compared to controls, SSc Patients had increased skin thickness at the first evaluation. Patients with dSSc had lower skin echogenicity than both patients with ISSc and the controls. Patients with greater changes in skin thickness and skin echogenicity produced more versican, whereas the production of biglycan and decorin was higher only, in patients with greater changes in skin echogenicity. There was a negative correlation between fibroblast production of biglycan and disease duration. Conclusion High fibroblast synthesis of the proteoglycans versican and biglycan is associated with changes in skin echogenicity and may predict more progressive skin sclerosis in SSc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ultrasound, systemic sclerosis, biglycan, versican
in
Clinical and Experimental Rheumatology
volume
20
issue
3
pages
301 - 308
publisher
Pacini
external identifiers
  • wos:000176072300003
  • scopus:0036558833
ISSN
1593-098X
language
English
LU publication?
yes
id
cbfe287f-cf27-4fcc-bb4d-5fcb39937e49 (old id 335559)
alternative location
http://www.clinexprheumatol.org/pdf/vol20/no3/20_3_pdf/4hesselstrand.pdf
date added to LUP
2007-10-19 15:03:18
date last changed
2017-01-01 04:34:13
@article{cbfe287f-cf27-4fcc-bb4d-5fcb39937e49,
  abstract     = {Objective To investigate a possible association between the longitudinal changes in skin involvement and the fibroblast production of proteoglycans in vitro, among patients with early and untreated systemic sclerosis (SSc). Methods In 11 patients, 6 with diffuse cutaneous systemic sclerosis (dSSc) and 5 with limited cutaneous systemic sclerosis (lSSc), and in 6 controls skin thickness and skin echogenicity, of the forearm was measured by high frequency (20 MHz) ultrasound, A skin biopsy was taken from the area of the ultrasound measurements, and from cultivated fibroblasts the production of the proteoglycans versican, perlecan, biglycan and decorin were measured. To investigate longitudinal changes in skin involvement, the ultrasound examination was repeated after 1-3 years. Results Compared to controls, SSc Patients had increased skin thickness at the first evaluation. Patients with dSSc had lower skin echogenicity than both patients with ISSc and the controls. Patients with greater changes in skin thickness and skin echogenicity produced more versican, whereas the production of biglycan and decorin was higher only, in patients with greater changes in skin echogenicity. There was a negative correlation between fibroblast production of biglycan and disease duration. Conclusion High fibroblast synthesis of the proteoglycans versican and biglycan is associated with changes in skin echogenicity and may predict more progressive skin sclerosis in SSc.},
  author       = {Hesselstrand, Roger and Westergren-Thorsson, Gunilla and Scheja, Agneta and Wildt, Marie and Åkesson, Anita},
  issn         = {1593-098X},
  keyword      = {ultrasound,systemic sclerosis,biglycan,versican},
  language     = {eng},
  number       = {3},
  pages        = {301--308},
  publisher    = {Pacini},
  series       = {Clinical and Experimental Rheumatology},
  title        = {The association between changes in skin echogenicity and the fibroblast production of biglycan and versican in systemic sclerosis},
  volume       = {20},
  year         = {2002},
}