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Non-contrast-enhanced magnetic resonance imaging can be used to assess renal cortical and medullary volumes-A validation study

Liefke, Jonas LU ; Steding-Ehrenborg, Katarina LU ; Asgeirsson, Daniel LU ; Nordlund, David LU ; Kopic, Sascha LU ; Morsing, Eva LU and Hedström, Erik LU orcid (2022) In Acta Radiologica Open 11(1). p.1-8
Abstract

Background: Magnetic resonance imaging (MRI) biomarkers can diagnose and prognosticate kidney disease. Renal volume validation studies are however scarce, and measurements are limited by use of contrast agent or advanced post-processing.

Purpose: To validate a widely available non-contrast-enhanced MRI method for quantification of renal cortical and medullary volumes in pigs; investigate observer variability of cortical and medullary volumes in humans; and present reference values for renal cortical and medullary volumes in adolescents.

Materials and Methods: Cortical and medullary volumes were quantified from transaxial in-vivo water-excited MR images in six pigs and 15 healthy adolescents (13-16years). Pig kidneys were... (More)

Background: Magnetic resonance imaging (MRI) biomarkers can diagnose and prognosticate kidney disease. Renal volume validation studies are however scarce, and measurements are limited by use of contrast agent or advanced post-processing.

Purpose: To validate a widely available non-contrast-enhanced MRI method for quantification of renal cortical and medullary volumes in pigs; investigate observer variability of cortical and medullary volumes in humans; and present reference values for renal cortical and medullary volumes in adolescents.

Materials and Methods: Cortical and medullary volumes were quantified from transaxial in-vivo water-excited MR images in six pigs and 15 healthy adolescents (13-16years). Pig kidneys were excised, and renal cortex and medulla were separately quantified by the water displacement method. Both limits of agreement by the Bland-Altman method and reference ranges are presented as 2.5-97.5 percentiles.

Results: Agreement between MRI and ex-vivo quantification were -7 mL (-10-0 mL) for total parenchyma, -4 mL (-9-3 mL) for cortex, and -2 mL (-7-2 mL) for medulla. Intraobserver variability for pig and human kidneys were <5% for total parenchyma, cortex, and medulla. Interobserver variability for both pig and human kidneys were ≤4% for total parenchyma and cortex, and 6% and 12% for medulla. Reference ranges indexed for body surface area and sex were 54-103 mL/m2 (boys) and 56-103 mL/m2 (girls) for total parenchyma, 39-62 mL/m2 and 36-68 mL/m2 for cortex, and 16-45 mL/m2 and 17-42 mL/m2 for medulla.

Conclusion: The proposed widely available non-contrast-enhanced MRI method can quantify cortical and medullary renal volumes and can be directly implemented clinically.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Radiologica Open
volume
11
issue
1
article number
20584601211072281
pages
1 - 8
publisher
SAGE Publications
external identifiers
  • pmid:35096415
ISSN
2058-4601
DOI
10.1177/20584601211072281
project
Very preterm birth and fetal growth restriction in adolescence - Cardiovascular and renal aspects
language
English
LU publication?
yes
additional info
© The Author(s) 2022.
id
340cdb67-7c72-4515-98d1-1ee3373daf54
date added to LUP
2022-03-23 08:45:48
date last changed
2025-04-04 13:51:43
@article{340cdb67-7c72-4515-98d1-1ee3373daf54,
  abstract     = {{<p>Background: Magnetic resonance imaging (MRI) biomarkers can diagnose and prognosticate kidney disease. Renal volume validation studies are however scarce, and measurements are limited by use of contrast agent or advanced post-processing.</p><p>Purpose: To validate a widely available non-contrast-enhanced MRI method for quantification of renal cortical and medullary volumes in pigs; investigate observer variability of cortical and medullary volumes in humans; and present reference values for renal cortical and medullary volumes in adolescents.</p><p>Materials and Methods: Cortical and medullary volumes were quantified from transaxial in-vivo water-excited MR images in six pigs and 15 healthy adolescents (13-16years). Pig kidneys were excised, and renal cortex and medulla were separately quantified by the water displacement method. Both limits of agreement by the Bland-Altman method and reference ranges are presented as 2.5-97.5 percentiles.</p><p>Results: Agreement between MRI and ex-vivo quantification were -7 mL (-10-0 mL) for total parenchyma, -4 mL (-9-3 mL) for cortex, and -2 mL (-7-2 mL) for medulla. Intraobserver variability for pig and human kidneys were &lt;5% for total parenchyma, cortex, and medulla. Interobserver variability for both pig and human kidneys were ≤4% for total parenchyma and cortex, and 6% and 12% for medulla. Reference ranges indexed for body surface area and sex were 54-103 mL/m2 (boys) and 56-103 mL/m2 (girls) for total parenchyma, 39-62 mL/m2 and 36-68 mL/m2 for cortex, and 16-45 mL/m2 and 17-42 mL/m2 for medulla.</p><p>Conclusion: The proposed widely available non-contrast-enhanced MRI method can quantify cortical and medullary renal volumes and can be directly implemented clinically.</p>}},
  author       = {{Liefke, Jonas and Steding-Ehrenborg, Katarina and Asgeirsson, Daniel and Nordlund, David and Kopic, Sascha and Morsing, Eva and Hedström, Erik}},
  issn         = {{2058-4601}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{1--8}},
  publisher    = {{SAGE Publications}},
  series       = {{Acta Radiologica Open}},
  title        = {{Non-contrast-enhanced magnetic resonance imaging can be used to assess renal cortical and medullary volumes-A validation study}},
  url          = {{http://dx.doi.org/10.1177/20584601211072281}},
  doi          = {{10.1177/20584601211072281}},
  volume       = {{11}},
  year         = {{2022}},
}