Non-contrast-enhanced magnetic resonance imaging can be used to assess renal cortical and medullary volumes-A validation study
(2022) In Acta Radiologica Open 11(1). p.1-8- Abstract
Background: Magnetic resonance imaging (MRI) biomarkers can diagnose and prognosticate kidney disease. Renal volume validation studies are however scarce, and measurements are limited by use of contrast agent or advanced post-processing.
Purpose: To validate a widely available non-contrast-enhanced MRI method for quantification of renal cortical and medullary volumes in pigs; investigate observer variability of cortical and medullary volumes in humans; and present reference values for renal cortical and medullary volumes in adolescents.
Materials and Methods: Cortical and medullary volumes were quantified from transaxial in-vivo water-excited MR images in six pigs and 15 healthy adolescents (13-16years). Pig kidneys were... (More)
Background: Magnetic resonance imaging (MRI) biomarkers can diagnose and prognosticate kidney disease. Renal volume validation studies are however scarce, and measurements are limited by use of contrast agent or advanced post-processing.
Purpose: To validate a widely available non-contrast-enhanced MRI method for quantification of renal cortical and medullary volumes in pigs; investigate observer variability of cortical and medullary volumes in humans; and present reference values for renal cortical and medullary volumes in adolescents.
Materials and Methods: Cortical and medullary volumes were quantified from transaxial in-vivo water-excited MR images in six pigs and 15 healthy adolescents (13-16years). Pig kidneys were excised, and renal cortex and medulla were separately quantified by the water displacement method. Both limits of agreement by the Bland-Altman method and reference ranges are presented as 2.5-97.5 percentiles.
Results: Agreement between MRI and ex-vivo quantification were -7 mL (-10-0 mL) for total parenchyma, -4 mL (-9-3 mL) for cortex, and -2 mL (-7-2 mL) for medulla. Intraobserver variability for pig and human kidneys were <5% for total parenchyma, cortex, and medulla. Interobserver variability for both pig and human kidneys were ≤4% for total parenchyma and cortex, and 6% and 12% for medulla. Reference ranges indexed for body surface area and sex were 54-103 mL/m2 (boys) and 56-103 mL/m2 (girls) for total parenchyma, 39-62 mL/m2 and 36-68 mL/m2 for cortex, and 16-45 mL/m2 and 17-42 mL/m2 for medulla.
Conclusion: The proposed widely available non-contrast-enhanced MRI method can quantify cortical and medullary renal volumes and can be directly implemented clinically.
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- author
- Liefke, Jonas LU ; Steding-Ehrenborg, Katarina LU ; Asgeirsson, Daniel LU ; Nordlund, David LU ; Kopic, Sascha LU ; Morsing, Eva LU and Hedström, Erik LU
- organization
- publishing date
- 2022-01-21
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Radiologica Open
- volume
- 11
- issue
- 1
- article number
- 20584601211072281
- pages
- 1 - 8
- publisher
- SAGE Publications
- external identifiers
-
- pmid:35096415
- ISSN
- 2058-4601
- DOI
- 10.1177/20584601211072281
- project
- Very preterm birth and fetal growth restriction in adolescence - Cardiovascular and renal aspects
- language
- English
- LU publication?
- yes
- additional info
- © The Author(s) 2022.
- id
- 340cdb67-7c72-4515-98d1-1ee3373daf54
- date added to LUP
- 2022-03-23 08:45:48
- date last changed
- 2022-07-08 08:46:34
@article{340cdb67-7c72-4515-98d1-1ee3373daf54, abstract = {{<p>Background: Magnetic resonance imaging (MRI) biomarkers can diagnose and prognosticate kidney disease. Renal volume validation studies are however scarce, and measurements are limited by use of contrast agent or advanced post-processing.</p><p>Purpose: To validate a widely available non-contrast-enhanced MRI method for quantification of renal cortical and medullary volumes in pigs; investigate observer variability of cortical and medullary volumes in humans; and present reference values for renal cortical and medullary volumes in adolescents.</p><p>Materials and Methods: Cortical and medullary volumes were quantified from transaxial in-vivo water-excited MR images in six pigs and 15 healthy adolescents (13-16years). Pig kidneys were excised, and renal cortex and medulla were separately quantified by the water displacement method. Both limits of agreement by the Bland-Altman method and reference ranges are presented as 2.5-97.5 percentiles.</p><p>Results: Agreement between MRI and ex-vivo quantification were -7 mL (-10-0 mL) for total parenchyma, -4 mL (-9-3 mL) for cortex, and -2 mL (-7-2 mL) for medulla. Intraobserver variability for pig and human kidneys were <5% for total parenchyma, cortex, and medulla. Interobserver variability for both pig and human kidneys were ≤4% for total parenchyma and cortex, and 6% and 12% for medulla. Reference ranges indexed for body surface area and sex were 54-103 mL/m2 (boys) and 56-103 mL/m2 (girls) for total parenchyma, 39-62 mL/m2 and 36-68 mL/m2 for cortex, and 16-45 mL/m2 and 17-42 mL/m2 for medulla.</p><p>Conclusion: The proposed widely available non-contrast-enhanced MRI method can quantify cortical and medullary renal volumes and can be directly implemented clinically.</p>}}, author = {{Liefke, Jonas and Steding-Ehrenborg, Katarina and Asgeirsson, Daniel and Nordlund, David and Kopic, Sascha and Morsing, Eva and Hedström, Erik}}, issn = {{2058-4601}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{1--8}}, publisher = {{SAGE Publications}}, series = {{Acta Radiologica Open}}, title = {{Non-contrast-enhanced magnetic resonance imaging can be used to assess renal cortical and medullary volumes-A validation study}}, url = {{http://dx.doi.org/10.1177/20584601211072281}}, doi = {{10.1177/20584601211072281}}, volume = {{11}}, year = {{2022}}, }