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HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.

Papadopoulou, Anastasia LU ; Lynch, Kristian LU ; Anderberg, Eva LU ; Landin-Olsson, Mona LU ; Jönsson, Ida LU ; Agardh, Carl-David LU ; Lernmark, Åke LU orcid and Berntorp, Kerstin LU (2012) In Diabetes Research and Clinical Practice 95. p.260-264
Abstract
AIMS: To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM). METHODS: During 2003-2004, women undergoing a 75g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off level defining GDM was a 2-h capillary blood glucose of 7.8mmol/L. 1-2 years after delivery a 75g OGTT was performed, GADA and IA-2A were measured and HLA-DQB1 genes analysed. Data were available for 452 mothers with previous GDM and 168 randomly selected control subjects. RESULTS: HLA-DQB1*0602 was negatively associated with GDM (p=0.033) and with... (More)
AIMS: To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM). METHODS: During 2003-2004, women undergoing a 75g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off level defining GDM was a 2-h capillary blood glucose of 7.8mmol/L. 1-2 years after delivery a 75g OGTT was performed, GADA and IA-2A were measured and HLA-DQB1 genes analysed. Data were available for 452 mothers with previous GDM and 168 randomly selected control subjects. RESULTS: HLA-DQB1*0602 was negatively associated with GDM (p=0.033) and with development of diabetes post partum (p=0.017), whereas high risk HLA were not associated with GDM or with diabetes. The presence of GADA post partum was positively associated with diabetes post partum (p=0.0009), but not with impaired glucose tolerance. CONCLUSIONS: Mothers with GDM and HLA-DQB1*0602 were less likely to develop diabetes after pregnancy, and type 1 diabetes associated high risk HLA genes did not predict type 1 diabetes post partum. Additionally, GADA were positively associated with diabetes development. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Research and Clinical Practice
volume
95
pages
260 - 264
publisher
Elsevier
external identifiers
  • wos:000299953900018
  • pmid:22104260
  • scopus:84856337975
  • pmid:22104260
ISSN
1872-8227
DOI
10.1016/j.diabres.2011.10.037
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diabetes and Celiac Unit (013241540), Paediatric Endocrinology Research Group (013243010), Medicine (Lund) (013230025), Department of Obstetrics and Gynaecology (Lund) (013018000), Diabetes and Endocrinology (013241530), Unit on Vascular Diabetic Complications (013241510)
id
342c1971-f125-40c4-b88b-c47cd4e7b98e (old id 2220566)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22104260?dopt=Abstract
date added to LUP
2016-04-04 07:27:06
date last changed
2024-03-13 08:29:28
@article{342c1971-f125-40c4-b88b-c47cd4e7b98e,
  abstract     = {{AIMS: To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM). METHODS: During 2003-2004, women undergoing a 75g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off level defining GDM was a 2-h capillary blood glucose of 7.8mmol/L. 1-2 years after delivery a 75g OGTT was performed, GADA and IA-2A were measured and HLA-DQB1 genes analysed. Data were available for 452 mothers with previous GDM and 168 randomly selected control subjects. RESULTS: HLA-DQB1*0602 was negatively associated with GDM (p=0.033) and with development of diabetes post partum (p=0.017), whereas high risk HLA were not associated with GDM or with diabetes. The presence of GADA post partum was positively associated with diabetes post partum (p=0.0009), but not with impaired glucose tolerance. CONCLUSIONS: Mothers with GDM and HLA-DQB1*0602 were less likely to develop diabetes after pregnancy, and type 1 diabetes associated high risk HLA genes did not predict type 1 diabetes post partum. Additionally, GADA were positively associated with diabetes development.}},
  author       = {{Papadopoulou, Anastasia and Lynch, Kristian and Anderberg, Eva and Landin-Olsson, Mona and Jönsson, Ida and Agardh, Carl-David and Lernmark, Åke and Berntorp, Kerstin}},
  issn         = {{1872-8227}},
  language     = {{eng}},
  pages        = {{260--264}},
  publisher    = {{Elsevier}},
  series       = {{Diabetes Research and Clinical Practice}},
  title        = {{HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.}},
  url          = {{http://dx.doi.org/10.1016/j.diabres.2011.10.037}},
  doi          = {{10.1016/j.diabres.2011.10.037}},
  volume       = {{95}},
  year         = {{2012}},
}