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Combinations of cereal β-glucans and probiotics can enhance the anti-inflammatory activity on host cells by a synergistic effect

Arena, Mattia Pia; Russo, Pasquale; Capozzi, Vittorio; Rascón, Ana LU ; Felis, Giovanna E.; Spano, Giuseppe and Fiocco, Daniela (2016) In Journal of Functional Foods 23. p.12-23
Abstract

The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were... (More)

The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were evidenced. In particular, mixtures of probiotic microorganisms and barley β-glucans exhibited synergistic effects in modulating the transcriptional level of several immune-related genes, leading to an overall enhanced anti-inflammatory effect. Together, these findings suggest a promising application of probiotic bacteria and β-glucans in the preparation of dietary mixtures presenting health-promoting features such as immunomodulatory properties.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Beta Glucan (PubChem CID: 9202437), Immune system, Prebiotics, Probiotics, Relative gene expression, Synbiotics, β-glucan
in
Journal of Functional Foods
volume
23
pages
12 pages
publisher
Elsevier
external identifiers
  • scopus:84959159638
  • wos:000376145200002
ISSN
1756-4646
DOI
10.1016/j.jff.2016.02.015
language
English
LU publication?
yes
id
3445335c-020d-4224-8714-51a188f2b38c
date added to LUP
2016-05-10 09:33:30
date last changed
2017-06-04 04:49:26
@article{3445335c-020d-4224-8714-51a188f2b38c,
  abstract     = {<p>The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were evidenced. In particular, mixtures of probiotic microorganisms and barley β-glucans exhibited synergistic effects in modulating the transcriptional level of several immune-related genes, leading to an overall enhanced anti-inflammatory effect. Together, these findings suggest a promising application of probiotic bacteria and β-glucans in the preparation of dietary mixtures presenting health-promoting features such as immunomodulatory properties.</p>},
  author       = {Arena, Mattia Pia and Russo, Pasquale and Capozzi, Vittorio and Rascón, Ana and Felis, Giovanna E. and Spano, Giuseppe and Fiocco, Daniela},
  issn         = {1756-4646},
  keyword      = {Beta Glucan (PubChem CID: 9202437),Immune system,Prebiotics,Probiotics,Relative gene expression,Synbiotics,β-glucan},
  language     = {eng},
  month        = {05},
  pages        = {12--23},
  publisher    = {Elsevier},
  series       = {Journal of Functional Foods},
  title        = {Combinations of cereal β-glucans and probiotics can enhance the anti-inflammatory activity on host cells by a synergistic effect},
  url          = {http://dx.doi.org/10.1016/j.jff.2016.02.015},
  volume       = {23},
  year         = {2016},
}