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Interaction Effect Between Copy Number Variation in Salivary Amylase Locus (AMY1) and Starch Intake on Glucose Homeostasis in the Malmö Diet and Cancer Cohort

Hamid, Aida Koder LU ; Andersson-Assarsson, Johanna ; Ericson, Ulrika LU and Sonestedt, Emily LU orcid (2021) In Frontiers in nutrition 7.
Abstract

Salivary amylase initiates the digestion of starch and it has been hypothesized that salivary amylase may play a role in the development of insulin resistance and type 2 diabetes. The aim was to examine the interaction between copy number variation in the salivary amylase gene AMY1 and starch intake. We studied 3,624 adults without diabetes or elevated blood glucose in the Malmö Diet Cancer cohort. We assessed the associations and interactions between starch intake, AMY1 copies and glucose homeostasis traits (i.e., fasting plasma glucose, insulin and HOMA-IR) and risk of type 2 diabetes over an average of 18 follow-up years. AMY1 copy number was not associated with glucose, insulin or HOMA-IR. We observed a significant interaction... (More)

Salivary amylase initiates the digestion of starch and it has been hypothesized that salivary amylase may play a role in the development of insulin resistance and type 2 diabetes. The aim was to examine the interaction between copy number variation in the salivary amylase gene AMY1 and starch intake. We studied 3,624 adults without diabetes or elevated blood glucose in the Malmö Diet Cancer cohort. We assessed the associations and interactions between starch intake, AMY1 copies and glucose homeostasis traits (i.e., fasting plasma glucose, insulin and HOMA-IR) and risk of type 2 diabetes over an average of 18 follow-up years. AMY1 copy number was not associated with glucose, insulin or HOMA-IR. We observed a significant interaction between starch intake and AMY1 copies on insulin and HOMA-IR after adjusting for potential confounders (p < 0.05). The inverse association between starch intake and insulin and HOMA-IR was stronger in the group with 10 or more copies (Ptrend < 0.001). In addition, we observed an inverse association between starch intake and type 2 diabetes in the group with 10 or more copies (ptrend = 0.003), but not in the other groups. This cross-sectional observational study suggests that AMY1 copy numbers might interact with starch intake on glucose homeostasis traits. Interventional studies are required to determine whether individuals with high AMY1 copy numbers may benefit from a high starch intake.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
copy number variation - CNV, dietary starch intake, epidemiology, insulin resistance (HOMA-IR), plasma glucose, salivary amylase gene, type 2 diabetes
in
Frontiers in nutrition
volume
7
article number
598850
publisher
Frontiers Media S. A.
external identifiers
  • pmid:33490099
  • scopus:85099729178
ISSN
2296-861X
DOI
10.3389/fnut.2020.598850
language
English
LU publication?
yes
id
356f87d1-7cb3-421d-9e00-7fd250d2b7b0
date added to LUP
2021-02-02 08:50:51
date last changed
2022-10-02 06:41:05
@article{356f87d1-7cb3-421d-9e00-7fd250d2b7b0,
  abstract     = {{<p>Salivary amylase initiates the digestion of starch and it has been hypothesized that salivary amylase may play a role in the development of insulin resistance and type 2 diabetes. The aim was to examine the interaction between copy number variation in the salivary amylase gene AMY1 and starch intake. We studied 3,624 adults without diabetes or elevated blood glucose in the Malmö Diet Cancer cohort. We assessed the associations and interactions between starch intake, AMY1 copies and glucose homeostasis traits (i.e., fasting plasma glucose, insulin and HOMA-IR) and risk of type 2 diabetes over an average of 18 follow-up years. AMY1 copy number was not associated with glucose, insulin or HOMA-IR. We observed a significant interaction between starch intake and AMY1 copies on insulin and HOMA-IR after adjusting for potential confounders (p &lt; 0.05). The inverse association between starch intake and insulin and HOMA-IR was stronger in the group with 10 or more copies (P<sub>trend</sub> &lt; 0.001). In addition, we observed an inverse association between starch intake and type 2 diabetes in the group with 10 or more copies (p<sub>trend</sub> = 0.003), but not in the other groups. This cross-sectional observational study suggests that AMY1 copy numbers might interact with starch intake on glucose homeostasis traits. Interventional studies are required to determine whether individuals with high AMY1 copy numbers may benefit from a high starch intake.</p>}},
  author       = {{Hamid, Aida Koder and Andersson-Assarsson, Johanna and Ericson, Ulrika and Sonestedt, Emily}},
  issn         = {{2296-861X}},
  keywords     = {{copy number variation - CNV; dietary starch intake; epidemiology; insulin resistance (HOMA-IR); plasma glucose; salivary amylase gene; type 2 diabetes}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in nutrition}},
  title        = {{Interaction Effect Between Copy Number Variation in Salivary Amylase Locus (AMY1) and Starch Intake on Glucose Homeostasis in the Malmö Diet and Cancer Cohort}},
  url          = {{http://dx.doi.org/10.3389/fnut.2020.598850}},
  doi          = {{10.3389/fnut.2020.598850}},
  volume       = {{7}},
  year         = {{2021}},
}