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Noninvasive mapping of water diffusional exchange in the human brain using filter-exchange imaging.

Nilsson, Markus LU ; Lätt, Jimmy LU ; van Westen, Danielle LU ; Brockstedt, Sara LU ; Lasič, Samo; Ståhlberg, Freddy LU and Topgaard, Daniel LU (2013) In Magnetic Resonance in Medicine 69(6). p.1572-1580
Abstract
We present the first in vivo application of the filter-exchange imaging protocol for diffusion MRI. The protocol allows noninvasive mapping of the rate of water exchange between microenvironments with different self-diffusivities, such as the intracellular and extracellular spaces in tissue. Since diffusional water exchange across the cell membrane is a fundamental process in human physiology and pathophysiology, clinically feasible and noninvasive imaging of the water exchange rate would offer new means to diagnose disease and monitor treatment response in conditions such as cancer and edema. The in vivo use of filter-exchange imaging was demonstrated by studying the brain of five healthy volunteers and one intracranial tumor... (More)
We present the first in vivo application of the filter-exchange imaging protocol for diffusion MRI. The protocol allows noninvasive mapping of the rate of water exchange between microenvironments with different self-diffusivities, such as the intracellular and extracellular spaces in tissue. Since diffusional water exchange across the cell membrane is a fundamental process in human physiology and pathophysiology, clinically feasible and noninvasive imaging of the water exchange rate would offer new means to diagnose disease and monitor treatment response in conditions such as cancer and edema. The in vivo use of filter-exchange imaging was demonstrated by studying the brain of five healthy volunteers and one intracranial tumor (meningioma). Apparent exchange rates in white matter range from 0.8 ± 0.08 s(-1) in the internal capsule, to 1.6 ± 0.11 s(-1) for frontal white matter, indicating that low values are associated with high myelination. Solid tumor displayed values of up to 2.9 ± 0.8 s(-1) . In white matter, the apparent exchange rate values suggest intra-axonal exchange times in the order of seconds, confirming the slow exchange assumption in the analysis of diffusion MRI data. We propose that filter-exchange imaging could be used clinically to map the water exchange rate in pathologies. Filter-exchange imaging may also be valuable for evaluating novel therapies targeting the function of aquaporins. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
author
organization
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type
Contribution to journal
publication status
published
subject
in
Magnetic Resonance in Medicine
volume
69
issue
6
pages
1572 - 1580
publisher
Wiley Online Library
external identifiers
  • wos:000319074100008
  • pmid:22837019
  • scopus:84878109511
ISSN
1522-2594
DOI
10.1002/mrm.24395
language
English
LU publication?
yes
id
370e8708-38d4-4c50-94c8-898e739c2796 (old id 2966485)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22837019?dopt=Abstract
date added to LUP
2012-08-10 09:25:50
date last changed
2019-07-16 01:04:14
@article{370e8708-38d4-4c50-94c8-898e739c2796,
  abstract     = {We present the first in vivo application of the filter-exchange imaging protocol for diffusion MRI. The protocol allows noninvasive mapping of the rate of water exchange between microenvironments with different self-diffusivities, such as the intracellular and extracellular spaces in tissue. Since diffusional water exchange across the cell membrane is a fundamental process in human physiology and pathophysiology, clinically feasible and noninvasive imaging of the water exchange rate would offer new means to diagnose disease and monitor treatment response in conditions such as cancer and edema. The in vivo use of filter-exchange imaging was demonstrated by studying the brain of five healthy volunteers and one intracranial tumor (meningioma). Apparent exchange rates in white matter range from 0.8 ± 0.08 s(-1) in the internal capsule, to 1.6 ± 0.11 s(-1) for frontal white matter, indicating that low values are associated with high myelination. Solid tumor displayed values of up to 2.9 ± 0.8 s(-1) . In white matter, the apparent exchange rate values suggest intra-axonal exchange times in the order of seconds, confirming the slow exchange assumption in the analysis of diffusion MRI data. We propose that filter-exchange imaging could be used clinically to map the water exchange rate in pathologies. Filter-exchange imaging may also be valuable for evaluating novel therapies targeting the function of aquaporins. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.},
  author       = {Nilsson, Markus and Lätt, Jimmy and van Westen, Danielle and Brockstedt, Sara and Lasič, Samo and Ståhlberg, Freddy and Topgaard, Daniel},
  issn         = {1522-2594},
  language     = {eng},
  number       = {6},
  pages        = {1572--1580},
  publisher    = {Wiley Online Library},
  series       = {Magnetic Resonance in Medicine},
  title        = {Noninvasive mapping of water diffusional exchange in the human brain using filter-exchange imaging.},
  url          = {http://dx.doi.org/10.1002/mrm.24395},
  volume       = {69},
  year         = {2013},
}