From starch to starch microspheres: Factors controlling the microspheres quality
Elfstrand, Lidia LU ; Eliasson, Ann-Charlotte LU ; Jönsson, Monica LU ; Reslow, Mats and Wahlgren, Marie LU
(2006)
In Stärke
58(8).
p.381-390
- Abstract
- Starch microparticle is a dosage form suitable for encapsulation of protein drugs. The microparticle characteristics can be influential factors for consecutive sustained drug release from the starch matrix and impact its ability to be coated by poly(D,L-lactide-co-glycolide). In this study, six types of starch microparticles were investigated and characterized. Desired qualities of the microspheres such as spherical form of the particles, well-defined and sharp particle contours were coincident with coarse surface morphology, sharp and distinct peaks in DSC and X-ray graphs. It was concluded that the quality of the starch microparticles was influenced by molecular properties of the starch material as well as type of buffer, and these... (More)
- Starch microparticle is a dosage form suitable for encapsulation of protein drugs. The microparticle characteristics can be influential factors for consecutive sustained drug release from the starch matrix and impact its ability to be coated by poly(D,L-lactide-co-glycolide). In this study, six types of starch microparticles were investigated and characterized. Desired qualities of the microspheres such as spherical form of the particles, well-defined and sharp particle contours were coincident with coarse surface morphology, sharp and distinct peaks in DSC and X-ray graphs. It was concluded that the quality of the starch microparticles was influenced by molecular properties of the starch material as well as type of buffer, and these factors were related to recrystallization kinetics, amount and quality of ordered/crystalline structure of final starch microspheres and their microscopic appearance. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/394305
- author
- Elfstrand, Lidia
LU
; Eliasson, Ann-Charlotte
LU
; Jönsson, Monica
LU
; Reslow, Mats
and Wahlgren, Marie
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- quality, product, microscopic appearance, starch microspheres, crystallinity
- in
- Stärke
- volume
- 58
- issue
- 8
- pages
- 381 - 390
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000240259700001
- scopus:33748454859
- ISSN
- 0038-9056
- DOI
- 10.1002/star.200600489
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Food Technology (011001017), Division of Nursing (Closed 2012) (013065000)
- id
- 40c18d03-ba2c-423f-bb24-8940b4bdcb7e (old id 394305)
- date added to LUP
- 2016-04-01 12:27:40
- date last changed
- 2023-11-12 01:42:14
@article{40c18d03-ba2c-423f-bb24-8940b4bdcb7e,
abstract = {{Starch microparticle is a dosage form suitable for encapsulation of protein drugs. The microparticle characteristics can be influential factors for consecutive sustained drug release from the starch matrix and impact its ability to be coated by poly(D,L-lactide-co-glycolide). In this study, six types of starch microparticles were investigated and characterized. Desired qualities of the microspheres such as spherical form of the particles, well-defined and sharp particle contours were coincident with coarse surface morphology, sharp and distinct peaks in DSC and X-ray graphs. It was concluded that the quality of the starch microparticles was influenced by molecular properties of the starch material as well as type of buffer, and these factors were related to recrystallization kinetics, amount and quality of ordered/crystalline structure of final starch microspheres and their microscopic appearance.}},
author = {{Elfstrand, Lidia and Eliasson, Ann-Charlotte and Jönsson, Monica and Reslow, Mats and Wahlgren, Marie}},
issn = {{0038-9056}},
keywords = {{quality; product; microscopic appearance; starch microspheres; crystallinity}},
language = {{eng}},
number = {{8}},
pages = {{381--390}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Stärke}},
title = {{From starch to starch microspheres: Factors controlling the microspheres quality}},
url = {{http://dx.doi.org/10.1002/star.200600489}},
doi = {{10.1002/star.200600489}},
volume = {{58}},
year = {{2006}},
}