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Intracellular complement and immunometabolism : The advantages of compartmentalization

King, Ben C. LU orcid and Blom, Anna M. LU orcid (2024) In European Journal of Immunology
Abstract

The complement system is a proteolytic cascade triggered by pathogen and danger-associated molecular patterns, with resultant outcomes of inflammation, cellular activation, and opsonization of material for removal by phagocytosis. While first discovered as an activity in serum, it is now recognized that complement components play important roles at local and individual cell-intrinsic levels. In particular, apart from the extracellular serum activities of complement, it is now believed that complement also acts intracellularly, as part of a cellular signal transduction cascade that can stimulate cellular survival and activation, and individual immune cell phenotypes, via effects on cellular metabolism. This review will describe what is... (More)

The complement system is a proteolytic cascade triggered by pathogen and danger-associated molecular patterns, with resultant outcomes of inflammation, cellular activation, and opsonization of material for removal by phagocytosis. While first discovered as an activity in serum, it is now recognized that complement components play important roles at local and individual cell-intrinsic levels. In particular, apart from the extracellular serum activities of complement, it is now believed that complement also acts intracellularly, as part of a cellular signal transduction cascade that can stimulate cellular survival and activation, and individual immune cell phenotypes, via effects on cellular metabolism. This review will describe what is currently known about how complement functions in intracellular signal transduction, and outline the functional advantages of a compartmentalized and intracellular complement system.

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Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Immunometabolism, Inflammation, Intracellular complement
in
European Journal of Immunology
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85193390903
  • pmid:38757569
ISSN
0014-2980
DOI
10.1002/eji.202350813
language
English
LU publication?
yes
id
39818b64-00dc-4b1a-b5e8-19d52e1dc67f
date added to LUP
2024-06-18 15:37:44
date last changed
2024-06-19 03:00:06
@article{39818b64-00dc-4b1a-b5e8-19d52e1dc67f,
  abstract     = {{<p>The complement system is a proteolytic cascade triggered by pathogen and danger-associated molecular patterns, with resultant outcomes of inflammation, cellular activation, and opsonization of material for removal by phagocytosis. While first discovered as an activity in serum, it is now recognized that complement components play important roles at local and individual cell-intrinsic levels. In particular, apart from the extracellular serum activities of complement, it is now believed that complement also acts intracellularly, as part of a cellular signal transduction cascade that can stimulate cellular survival and activation, and individual immune cell phenotypes, via effects on cellular metabolism. This review will describe what is currently known about how complement functions in intracellular signal transduction, and outline the functional advantages of a compartmentalized and intracellular complement system.</p>}},
  author       = {{King, Ben C. and Blom, Anna M.}},
  issn         = {{0014-2980}},
  keywords     = {{Immunometabolism; Inflammation; Intracellular complement}},
  language     = {{eng}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{European Journal of Immunology}},
  title        = {{Intracellular complement and immunometabolism : The advantages of compartmentalization}},
  url          = {{http://dx.doi.org/10.1002/eji.202350813}},
  doi          = {{10.1002/eji.202350813}},
  year         = {{2024}},
}