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Deregulation of protein phosphatase expression in acute myeloid leukemia

Kabir, Nuzhat N.; Rönnstrand, Lars LU and Kazi, Julhash U. LU (2013) In Medical Oncology 30(2).
Abstract
Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in... (More)
Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Dual specificity, Protein serine/threonine phosphatase, phosphatase, Protein tyrosine, Protein phosphatase, Acute myeloid leukemia, AML
in
Medical Oncology
volume
30
issue
2
publisher
Humana Press
external identifiers
  • wos:000319450400026
  • scopus:84874088035
ISSN
1559-131X
DOI
10.1007/s12032-013-0517-8
language
English
LU publication?
yes
id
9a2c8ce8-c876-4896-955d-481ae84e03a8 (old id 3990389)
date added to LUP
2013-09-02 07:28:49
date last changed
2018-11-21 20:29:08
@article{9a2c8ce8-c876-4896-955d-481ae84e03a8,
  abstract     = {Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML.},
  author       = {Kabir, Nuzhat N. and Rönnstrand, Lars and Kazi, Julhash U.},
  issn         = {1559-131X},
  keyword      = {Dual specificity,Protein serine/threonine phosphatase,phosphatase,Protein tyrosine,Protein phosphatase,Acute myeloid leukemia,AML},
  language     = {eng},
  number       = {2},
  publisher    = {Humana Press},
  series       = {Medical Oncology},
  title        = {Deregulation of protein phosphatase expression in acute myeloid leukemia},
  url          = {http://dx.doi.org/10.1007/s12032-013-0517-8},
  volume       = {30},
  year         = {2013},
}