Jaboticaba peel intake improved cognitive performance, inflammatory response, and appetite regulation in healthy adults : a randomized clinical crossover trial
(2025) In Food Research International 221.- Abstract
Jaboticaba (Plinia jaboticaba) is an underutilized Brazilian berry and a source of dietary fiber, cyanidin-3-O-glucoside, and ellagic acid derivatives. Non-clinical studies have shown the potential of jaboticaba to alleviate insulin resistance, low-grade inflammation, and obesity-related cognitive decline, although clinical evidence remains limited. A clinical study was conducted to investigate whether similar effects could be replicated in human subjects following the intake of jaboticaba peel powder (JPP). Nineteen healthy adults (8 men; 11 women; average age 27.5 years and body mass index 24.6 kg/m2) completed a 4-week randomized, controlled, crossover intervention with a 28-day washout period. Participants consumed either... (More)
Jaboticaba (Plinia jaboticaba) is an underutilized Brazilian berry and a source of dietary fiber, cyanidin-3-O-glucoside, and ellagic acid derivatives. Non-clinical studies have shown the potential of jaboticaba to alleviate insulin resistance, low-grade inflammation, and obesity-related cognitive decline, although clinical evidence remains limited. A clinical study was conducted to investigate whether similar effects could be replicated in human subjects following the intake of jaboticaba peel powder (JPP). Nineteen healthy adults (8 men; 11 women; average age 27.5 years and body mass index 24.6 kg/m2) completed a 4-week randomized, controlled, crossover intervention with a 28-day washout period. Participants consumed either 7 g/day of JPP, providing 225 mg of total polyphenols (including 78 mg of cyanidin-3-O-glucoside and 50 mg of ellagic acid), 2.4 g of dietary fiber, and 1.8 g of insoluble fiber, or a matched control containing equivalent sugar and insoluble fiber, blended in water. A standardized carbohydrate-rich meal was also administered. Fasting and postprandial blood samples were collected on days 1 and 28. The interventions did not show a significant effect on postprandial glucose, insulin, adiponectin, or non-esterified fatty acids (p > 0.05). However, fasting and postprandial levels of the proinflammatory cytokine interleukin-6 were 30–40 % lower following JPP consumption (p < 0.05). Additionally, oxidative species decreased by 9 % postprandially (p < 0.01). Furthermore, JPP significantly improved subjective appetite (∼10 %, p < 0.05) and enhanced postprandial selective attention after 45 min (p < 0.05). These findings suggest that jaboticaba peel may provide anti-inflammatory, antioxidant, and cognitive benefits in healthy individuals, supporting its potential as a functional food ingredient.
(Less)
- author
- Batista, Angela Giovana LU ; Zanzer, Yoghatama Cindya LU ; Marostica Junior, Mario Roberto and Östman, Elin M. LU
- organization
- publishing date
- 2025
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anthocyanins., Anti-inflammatory effects., Antioxidant activity., Functional foods, Jaboticaba., Myrciaria Jaboticaba., Phenolic compounds.
- in
- Food Research International
- volume
- 221
- article number
- 117390
- publisher
- Elsevier
- external identifiers
-
- scopus:105014599033
- ISSN
- 0963-9969
- DOI
- 10.1016/j.foodres.2025.117390
- language
- English
- LU publication?
- yes
- id
- 3a0e5862-4198-4901-ba95-28130562e06b
- date added to LUP
- 2025-10-03 09:13:23
- date last changed
- 2025-10-14 11:03:44
@article{3a0e5862-4198-4901-ba95-28130562e06b,
abstract = {{<p>Jaboticaba (Plinia jaboticaba) is an underutilized Brazilian berry and a source of dietary fiber, cyanidin-3-O-glucoside, and ellagic acid derivatives. Non-clinical studies have shown the potential of jaboticaba to alleviate insulin resistance, low-grade inflammation, and obesity-related cognitive decline, although clinical evidence remains limited. A clinical study was conducted to investigate whether similar effects could be replicated in human subjects following the intake of jaboticaba peel powder (JPP). Nineteen healthy adults (8 men; 11 women; average age 27.5 years and body mass index 24.6 kg/m<sup>2</sup>) completed a 4-week randomized, controlled, crossover intervention with a 28-day washout period. Participants consumed either 7 g/day of JPP, providing 225 mg of total polyphenols (including 78 mg of cyanidin-3-O-glucoside and 50 mg of ellagic acid), 2.4 g of dietary fiber, and 1.8 g of insoluble fiber, or a matched control containing equivalent sugar and insoluble fiber, blended in water. A standardized carbohydrate-rich meal was also administered. Fasting and postprandial blood samples were collected on days 1 and 28. The interventions did not show a significant effect on postprandial glucose, insulin, adiponectin, or non-esterified fatty acids (p > 0.05). However, fasting and postprandial levels of the proinflammatory cytokine interleukin-6 were 30–40 % lower following JPP consumption (p < 0.05). Additionally, oxidative species decreased by 9 % postprandially (p < 0.01). Furthermore, JPP significantly improved subjective appetite (∼10 %, p < 0.05) and enhanced postprandial selective attention after 45 min (p < 0.05). These findings suggest that jaboticaba peel may provide anti-inflammatory, antioxidant, and cognitive benefits in healthy individuals, supporting its potential as a functional food ingredient.</p>}},
author = {{Batista, Angela Giovana and Zanzer, Yoghatama Cindya and Marostica Junior, Mario Roberto and Östman, Elin M.}},
issn = {{0963-9969}},
keywords = {{Anthocyanins.; Anti-inflammatory effects.; Antioxidant activity.; Functional foods; Jaboticaba.; Myrciaria Jaboticaba.; Phenolic compounds.}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Food Research International}},
title = {{Jaboticaba peel intake improved cognitive performance, inflammatory response, and appetite regulation in healthy adults : a randomized clinical crossover trial}},
url = {{http://dx.doi.org/10.1016/j.foodres.2025.117390}},
doi = {{10.1016/j.foodres.2025.117390}},
volume = {{221}},
year = {{2025}},
}