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Familial risks between Graves disease and Hashimoto thyroiditis and other autoimmune diseases in the population of Sweden

Thomsen, Hauke LU ; Li, Xinjun LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Försti, Asta LU and Hemminki, Kari LU (2020) In Journal of Translational Autoimmunity 3.
Abstract
Genetic and family studies have indicated that Graves disease and Hashimoto thyroiditis have a heritable component which appears to be shared to some extend also with some other autoimmune diseases (AIDs). In the present nation-wide study we describe familial risk for Graves disease and Hashimoto thyroiditis identified from the Swedish Hospital Discharge Register (years 1964 through 2012) and the Outpatient Register (2001 through 2012). Family relationships were obtained from the Multigeneration Register and cancers from the Cancer Registry. Familial standardized incidence ratios (SIRs) were calculated for 29,005 offspring with Graves disease and for 25,607 offspring with Hashimoto thyroiditis depending on any of 43 AIDs in parents or... (More)
Genetic and family studies have indicated that Graves disease and Hashimoto thyroiditis have a heritable component which appears to be shared to some extend also with some other autoimmune diseases (AIDs). In the present nation-wide study we describe familial risk for Graves disease and Hashimoto thyroiditis identified from the Swedish Hospital Discharge Register (years 1964 through 2012) and the Outpatient Register (2001 through 2012). Family relationships were obtained from the Multigeneration Register and cancers from the Cancer Registry. Familial standardized incidence ratios (SIRs) were calculated for 29,005 offspring with Graves disease and for 25,607 offspring with Hashimoto thyroiditis depending on any of 43 AIDs in parents or siblings. The concordant familial risks for Graves disease and Hashimoto thyroiditis were 3.85 and 4.75, higher for men than for women. The familial risks were very high (11.35, Graves and 22.06, Hashimoto) when both a parent and a sibling were affected. Spousal familial risks were higher for Hashimoto thyroiditis (1.98/1.93) than for Graves disease (1.48/1.50). For Graves disease, 24 discordant AIDs showed a significant association; for Hashimoto thyroiditis, 20 discordant associations were significant. All significant discordant associations were positive for the two thyroid AIDs, with the exception of Hashimoto thyroiditis with Reiter disease. Overall 8 associations were significant only for Graves disease and 6 Hashimoto thyroiditis. The overall high concordant familial risks for Graves disease and Hashimoto thyroiditis suggest a strong genetic contribution to the familial risk. Significant familial associations among more than half of the 43 AIDs attest to the extensive polyautoimmunity among thyroid AIDs. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
Genetics, Risk between spouses, Discordant risks, Polyautoimmunity
in
Journal of Translational Autoimmunity
volume
3
ISSN
2589-9090
DOI
10.1016/j.jtauto.2020.100058
language
English
LU publication?
yes
id
3ad5bd6a-d847-4645-967c-ea4fb6143c9e
alternative location
http://www.sciencedirect.com/science/article/pii/S2589909020300253
date added to LUP
2020-07-31 13:31:07
date last changed
2020-07-31 13:31:07
@article{3ad5bd6a-d847-4645-967c-ea4fb6143c9e,
  abstract     = {Genetic and family studies have indicated that Graves disease and Hashimoto thyroiditis have a heritable component which appears to be shared to some extend also with some other autoimmune diseases (AIDs). In the present nation-wide study we describe familial risk for Graves disease and Hashimoto thyroiditis identified from the Swedish Hospital Discharge Register (years 1964 through 2012) and the Outpatient Register (2001 through 2012). Family relationships were obtained from the Multigeneration Register and cancers from the Cancer Registry. Familial standardized incidence ratios (SIRs) were calculated for 29,005 offspring with Graves disease and for 25,607 offspring with Hashimoto thyroiditis depending on any of 43 AIDs in parents or siblings. The concordant familial risks for Graves disease and Hashimoto thyroiditis were 3.85 and 4.75, higher for men than for women. The familial risks were very high (11.35, Graves and 22.06, Hashimoto) when both a parent and a sibling were affected. Spousal familial risks were higher for Hashimoto thyroiditis (1.98/1.93) than for Graves disease (1.48/1.50). For Graves disease, 24 discordant AIDs showed a significant association; for Hashimoto thyroiditis, 20 discordant associations were significant. All significant discordant associations were positive for the two thyroid AIDs, with the exception of Hashimoto thyroiditis with Reiter disease. Overall 8 associations were significant only for Graves disease and 6 Hashimoto thyroiditis. The overall high concordant familial risks for Graves disease and Hashimoto thyroiditis suggest a strong genetic contribution to the familial risk. Significant familial associations among more than half of the 43 AIDs attest to the extensive polyautoimmunity among thyroid AIDs.},
  author       = {Thomsen, Hauke and Li, Xinjun and Sundquist, Kristina and Sundquist, Jan and Försti, Asta and Hemminki, Kari},
  issn         = {2589-9090},
  language     = {eng},
  series       = {Journal of Translational Autoimmunity},
  title        = {Familial risks between Graves disease and Hashimoto thyroiditis and other autoimmune diseases in the population of Sweden},
  url          = {http://dx.doi.org/10.1016/j.jtauto.2020.100058},
  doi          = {10.1016/j.jtauto.2020.100058},
  volume       = {3},
  year         = {2020},
}