Serum immunoglobulin concentrations and risk of type 2 diabetes mellitus in adults : a prospective cohort study from the TCLSIH study
(2024) In BMC Immunology 25(1).- Abstract
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin action. Increasing evidence suggests that inflammation played an important role in the pathogenesis of T2DM. Prospective studies on the link between immunoglobulins concentrations and the risk of T2DM in adults are limited. We developed a cohort study including 7,093 adults without T2DM history. The incidence of T2DM was 16.45 per 1,000 person-years. Compared with the lowest quartiles, the hazard ratios (95% confidence intervals) of T2DM for the highest quartiles of IgG, IgE, IgM and IgA were 0.64 (0.48–0.85), 0.94 (0.72–1.23), 0.68 (0.50–0.92) and 1.62 (1.24–2.11) (P for trend was < 0.01,... (More)
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin action. Increasing evidence suggests that inflammation played an important role in the pathogenesis of T2DM. Prospective studies on the link between immunoglobulins concentrations and the risk of T2DM in adults are limited. We developed a cohort study including 7,093 adults without T2DM history. The incidence of T2DM was 16.45 per 1,000 person-years. Compared with the lowest quartiles, the hazard ratios (95% confidence intervals) of T2DM for the highest quartiles of IgG, IgE, IgM and IgA were 0.64 (0.48–0.85), 0.94 (0.72–1.23), 0.68 (0.50–0.92) and 1.62 (1.24–2.11) (P for trend was < 0.01, 0.84, 0.02 and < 0.0001), respectively, suggesting that serum IgG and IgM concentrations were inversely associated with the incidence of T2DM, and IgA levels were positively associated with the risk of T2DM in a general adult population.
(Less)
- author
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adults, Immunoglobulin concentrations, Prospective study, T2DM
- in
- BMC Immunology
- volume
- 25
- issue
- 1
- article number
- 52
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85199987969
- pmid:39075358
- ISSN
- 1471-2172
- DOI
- 10.1186/s12865-024-00637-9
- language
- English
- LU publication?
- yes
- id
- 3bca6fd0-4b34-4416-a9a9-ccaa1818477e
- date added to LUP
- 2024-08-30 12:37:37
- date last changed
- 2024-08-31 03:00:11
@article{3bca6fd0-4b34-4416-a9a9-ccaa1818477e, abstract = {{<p>Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin action. Increasing evidence suggests that inflammation played an important role in the pathogenesis of T2DM. Prospective studies on the link between immunoglobulins concentrations and the risk of T2DM in adults are limited. We developed a cohort study including 7,093 adults without T2DM history. The incidence of T2DM was 16.45 per 1,000 person-years. Compared with the lowest quartiles, the hazard ratios (95% confidence intervals) of T2DM for the highest quartiles of IgG, IgE, IgM and IgA were 0.64 (0.48–0.85), 0.94 (0.72–1.23), 0.68 (0.50–0.92) and 1.62 (1.24–2.11) (P for trend was < 0.01, 0.84, 0.02 and < 0.0001), respectively, suggesting that serum IgG and IgM concentrations were inversely associated with the incidence of T2DM, and IgA levels were positively associated with the risk of T2DM in a general adult population.</p>}}, author = {{Zhang, Li and Li, Yuanbin and Wang, Honglei and Guo, Yirui and Wang, Xiaotong and Wu, Hongmei and Zhang, Qing and Liu, Li and Meng, Ge and Zhang, Shunming and Sun, Shaomei and Zhou, Ming and Jia, Qiyu and Song, Kun and Stubbendorff, Anna and Gu, Yeqing and Niu, Kaijun}}, issn = {{1471-2172}}, keywords = {{Adults; Immunoglobulin concentrations; Prospective study; T2DM}}, language = {{eng}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Immunology}}, title = {{Serum immunoglobulin concentrations and risk of type 2 diabetes mellitus in adults : a prospective cohort study from the TCLSIH study}}, url = {{http://dx.doi.org/10.1186/s12865-024-00637-9}}, doi = {{10.1186/s12865-024-00637-9}}, volume = {{25}}, year = {{2024}}, }