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Serum immunoglobulin concentrations and risk of type 2 diabetes mellitus in adults : a prospective cohort study from the TCLSIH study

Zhang, Li ; Li, Yuanbin ; Wang, Honglei ; Guo, Yirui ; Wang, Xiaotong ; Wu, Hongmei ; Zhang, Qing ; Liu, Li ; Meng, Ge and Zhang, Shunming LU , et al. (2024) In BMC Immunology 25(1).
Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin action. Increasing evidence suggests that inflammation played an important role in the pathogenesis of T2DM. Prospective studies on the link between immunoglobulins concentrations and the risk of T2DM in adults are limited. We developed a cohort study including 7,093 adults without T2DM history. The incidence of T2DM was 16.45 per 1,000 person-years. Compared with the lowest quartiles, the hazard ratios (95% confidence intervals) of T2DM for the highest quartiles of IgG, IgE, IgM and IgA were 0.64 (0.48–0.85), 0.94 (0.72–1.23), 0.68 (0.50–0.92) and 1.62 (1.24–2.11) (P for trend was < 0.01,... (More)

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin action. Increasing evidence suggests that inflammation played an important role in the pathogenesis of T2DM. Prospective studies on the link between immunoglobulins concentrations and the risk of T2DM in adults are limited. We developed a cohort study including 7,093 adults without T2DM history. The incidence of T2DM was 16.45 per 1,000 person-years. Compared with the lowest quartiles, the hazard ratios (95% confidence intervals) of T2DM for the highest quartiles of IgG, IgE, IgM and IgA were 0.64 (0.48–0.85), 0.94 (0.72–1.23), 0.68 (0.50–0.92) and 1.62 (1.24–2.11) (P for trend was < 0.01, 0.84, 0.02 and < 0.0001), respectively, suggesting that serum IgG and IgM concentrations were inversely associated with the incidence of T2DM, and IgA levels were positively associated with the risk of T2DM in a general adult population.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adults, Immunoglobulin concentrations, Prospective study, T2DM
in
BMC Immunology
volume
25
issue
1
article number
52
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85199987969
  • pmid:39075358
ISSN
1471-2172
DOI
10.1186/s12865-024-00637-9
language
English
LU publication?
yes
id
3bca6fd0-4b34-4416-a9a9-ccaa1818477e
date added to LUP
2024-08-30 12:37:37
date last changed
2024-11-22 22:50:05
@article{3bca6fd0-4b34-4416-a9a9-ccaa1818477e,
  abstract     = {{<p>Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin action. Increasing evidence suggests that inflammation played an important role in the pathogenesis of T2DM. Prospective studies on the link between immunoglobulins concentrations and the risk of T2DM in adults are limited. We developed a cohort study including 7,093 adults without T2DM history. The incidence of T2DM was 16.45 per 1,000 person-years. Compared with the lowest quartiles, the hazard ratios (95% confidence intervals) of T2DM for the highest quartiles of IgG, IgE, IgM and IgA were 0.64 (0.48–0.85), 0.94 (0.72–1.23), 0.68 (0.50–0.92) and 1.62 (1.24–2.11) (P for trend was &lt; 0.01, 0.84, 0.02 and &lt; 0.0001), respectively, suggesting that serum IgG and IgM concentrations were inversely associated with the incidence of T2DM, and IgA levels were positively associated with the risk of T2DM in a general adult population.</p>}},
  author       = {{Zhang, Li and Li, Yuanbin and Wang, Honglei and Guo, Yirui and Wang, Xiaotong and Wu, Hongmei and Zhang, Qing and Liu, Li and Meng, Ge and Zhang, Shunming and Sun, Shaomei and Zhou, Ming and Jia, Qiyu and Song, Kun and Stubbendorff, Anna and Gu, Yeqing and Niu, Kaijun}},
  issn         = {{1471-2172}},
  keywords     = {{Adults; Immunoglobulin concentrations; Prospective study; T2DM}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Immunology}},
  title        = {{Serum immunoglobulin concentrations and risk of type 2 diabetes mellitus in adults : a prospective cohort study from the TCLSIH study}},
  url          = {{http://dx.doi.org/10.1186/s12865-024-00637-9}},
  doi          = {{10.1186/s12865-024-00637-9}},
  volume       = {{25}},
  year         = {{2024}},
}