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Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations

Midttun, Øivind; Theofylaktopoulou, Despoina; McCann, Adrian; Fanidi, Anouar; Muller, David C; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao Ou and Xiang, Yong-Bing, et al. (2017) In American Journal of Clinical Nutrition 105(6). p.1314-1326
Abstract

Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic... (More)

Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.

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keywords
Biomarker, Lung Cancer Cohort Consortium, One-carbon metabolism, Tryptophan metabolism, Vitamin status
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American Journal of Clinical Nutrition
volume
105
issue
6
pages
13 pages
publisher
American Society for Clinical Nutrition
external identifiers
  • scopus:85020506629
  • wos:000402612200010
ISSN
0002-9165
DOI
10.3945/ajcn.116.151241
language
English
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yes
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3d99fcd7-2e40-4a10-8263-f211cc9e06de
date added to LUP
2017-08-17 15:02:27
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2017-09-18 11:41:52
@article{3d99fcd7-2e40-4a10-8263-f211cc9e06de,
  abstract     = {<p>Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.</p>},
  author       = {Midttun, Øivind and Theofylaktopoulou, Despoina and McCann, Adrian and Fanidi, Anouar and Muller, David C and Meyer, Klaus and Ulvik, Arve and Zheng, Wei and Shu, Xiao Ou and Xiang, Yong-Bing and Prentice, Ross and Thomson, Cynthia A. and Pettinger, Mary and Giles, Graham G. and Hodge, Allison M. and Cai, Qiuyin and Blot, William J. and Wu, Jie and Johansson, Mikael and Hultdin, Johan and Grankvist, Kjell and Stevens, Victoria L. and McCullough, Marjorie L. and Weinstein, Stephanie J. and Albanes, Demetrius and Langhammer, Arnulf and Hveem, Kristian and Næss, Marit and Sesso, Howard D and Gaziano, J Michael and Buring, Julie E. and Lee, I. Min and Severi, Gianluca and Zhang, Xuehong and Han, Jiali and Stampfer, Meir J. and Smith-Warner, Stephanie A. and Zeleniuch-Jacquotte, Anne and Le Marchand, Loic and Yuan, Jian-Min and Butler, Lesley M and Koh, Woon-Puay and Wang, Renwei and Gao, Yu-Tang and Ericson, Ulrika and Sonestedt, Emily and Ziegler, Regina G. and Freedman, Neal D. and Visvanathan, Kala and Jones, Miranda R. and Relton, Caroline L and Brennan, Paul and Johansson, Mattias and Ueland, Per M.},
  issn         = {0002-9165},
  keyword      = {Biomarker,Lung Cancer Cohort Consortium,One-carbon metabolism,Tryptophan metabolism,Vitamin status},
  language     = {eng},
  number       = {6},
  pages        = {1314--1326},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations},
  url          = {http://dx.doi.org/10.3945/ajcn.116.151241},
  volume       = {105},
  year         = {2017},
}