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Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition

Luczynska, Anna; Kaaks, Rudolf; Rohrmann, Sabine; Becker, Susen; Linseisen, Jakob; Buijsse, Brian; Overvad, Kim; Trichopoulou, Antonia; Valanou, Elisavet and Barmpitsioti, Antonia, et al. (2013) In American Journal of Clinical Nutrition 98(3). p.827-838
Abstract
Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and season-specific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant... (More)
Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and season-specific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (P-heterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with >= 2y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). Conclusions: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL. (Less)
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American Journal of Clinical Nutrition
volume
98
issue
3
pages
827 - 838
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000323532700026
  • scopus:84883143983
ISSN
1938-3207
DOI
10.3945/ajcn.112.054676
language
English
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yes
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3ea47ce9-b4bf-485c-8919-6706cf8aacb7 (old id 4062717)
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2014-03-03 08:10:39
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@article{3ea47ce9-b4bf-485c-8919-6706cf8aacb7,
  abstract     = {Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and season-specific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (P-heterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with >= 2y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). Conclusions: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.},
  author       = {Luczynska, Anna and Kaaks, Rudolf and Rohrmann, Sabine and Becker, Susen and Linseisen, Jakob and Buijsse, Brian and Overvad, Kim and Trichopoulou, Antonia and Valanou, Elisavet and Barmpitsioti, Antonia and Masala, Giovanna and Agnoli, Claudia and Tumino, Rosario and Panico, Salvatore and Bueno-de-Mesquita, H. Bas and van Duijnhoven, Franzel J. B. and Peeters, Petra H. M. and Vernieulen, Roel and Weiderpass, Elisabete and Brustad, Magritt and Skeie, Guri and Gonzalez, Carlos A. and Jakszyn, Paula and Ramon Quiros, J. and Sanchez, Maria-Jose and Huerta, Jose-Maria and Ardanaz, Eva and Melin, Beatrice and Johansson, Ann Sofie and Almquist, Martin and Malm, Johan and Khaw, Kay-Tee and Wareham, Nick and Travis, Ruth C. and Fedirko, Veronika and Romieu, Isabelle and Jenab, Mazda and Gallo, Valentina and Riboli, Elio and Vineis, Paolo and Nieters, Alexandra},
  issn         = {1938-3207},
  language     = {eng},
  number       = {3},
  pages        = {827--838},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.3945/ajcn.112.054676},
  volume       = {98},
  year         = {2013},
}