Effects of red blood cell transfusions given to non-septic critically ill patients : a propensity score matched study
Kander, Thomas LU
; Nilsson, Caroline U.
LU
; Larsson, Daniel
and Bentzer, Peter
LU
(2021)
In Anaesthesiology Intensive Therapy
53(5).
p.390-397
- Abstract
Background: Previous studies have demonstrated that low-grade red blood cell transfusions (RBC) given to septic patients are harmful. The objectives of the present study were to compare mortality and morbidity in non-septic critically ill patients who were given low-grade RBC transfusions at haemoglobin level > 70 g L–1 with patients without RBC-transfusions any of the first 5 days in intensive care. Methods: Adult patients admitted to a general intensive care unit between 2007 and 2018 at a university hospital were eligible for inclusion. Patients who received > 2 units RBC transfusion per day during the first 5 days after admisasion, with pre-transfusion haemoglobin level < 70 g L–1 or with severe sepsis... (More)
Background: Previous studies have demonstrated that low-grade red blood cell transfusions (RBC) given to septic patients are harmful. The objectives of the present study were to compare mortality and morbidity in non-septic critically ill patients who were given low-grade RBC transfusions at haemoglobin level > 70 g L–1 with patients without RBC-transfusions any of the first 5 days in intensive care. Methods: Adult patients admitted to a general intensive care unit between 2007 and 2018 at a university hospital were eligible for inclusion. Patients who received > 2 units RBC transfusion per day during the first 5 days after admisasion, with pre-transfusion haemoglobin level < 70 g L–1 or with severe sepsis or septic shock, were excluded. Results: In total, 9491 admissions were recorded during the study period. Propensity score matching resulted in 2 well matched groups with 674 unique patients in each. Median pre-transfusion haemoglobin was 98 g L–1 (interquartile range 91–107 g L–1). Mortality was higher in the RBC group with an absolute risk increase for death at 180 days of 5.9% (95% CI: 3.6–8.3; P< 0.001). Low-grade RBC-transfusion was also associated with renal, circulatory, and respiratory failure as well as a higher SOFA-max score. Sensitivity analyses suggested that disease trajectories during the exposure time did not significantly differ between the groups. Conclusions: Low-grade RBC-transfusions given to non-septic critically ill patients without significant anaemia were associated with increased mortality, increased kidney, circulatory, and respiratory failure, as well as higher SOFA-max score.
(Less)
- author
- Kander, Thomas
LU
; Nilsson, Caroline U.
LU
; Larsson, Daniel
and Bentzer, Peter
LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Blood transfusion, Circulatory failure, Days alive and free, Erythrocyte transfusion, Mortality, Renal failure, Respiratory failure
- in
- Anaesthesiology Intensive Therapy
- volume
- 53
- issue
- 5
- pages
- 390 - 397
- publisher
- Via Medica
- external identifiers
-
- pmid:35100796
- scopus:85123017405
- ISSN
- 1642-5758
- DOI
- 10.5114/ait.2021.111739
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 Via Medica. All rights reserved.
- id
- 3ef4f455-10ca-448a-a32d-530de20104ea
- date added to LUP
- 2022-01-27 22:27:18
- date last changed
- 2024-04-06 17:19:27
@article{3ef4f455-10ca-448a-a32d-530de20104ea,
abstract = {{<p>Background: Previous studies have demonstrated that low-grade red blood cell transfusions (RBC) given to septic patients are harmful. The objectives of the present study were to compare mortality and morbidity in non-septic critically ill patients who were given low-grade RBC transfusions at haemoglobin level > 70 g L<sup>–1</sup> with patients without RBC-transfusions any of the first 5 days in intensive care. Methods: Adult patients admitted to a general intensive care unit between 2007 and 2018 at a university hospital were eligible for inclusion. Patients who received > 2 units RBC transfusion per day during the first 5 days after admisasion, with pre-transfusion haemoglobin level < 70 g L<sup>–1</sup> or with severe sepsis or septic shock, were excluded. Results: In total, 9491 admissions were recorded during the study period. Propensity score matching resulted in 2 well matched groups with 674 unique patients in each. Median pre-transfusion haemoglobin was 98 g L<sup>–1</sup> (interquartile range 91–107 g L<sup>–1</sup>). Mortality was higher in the RBC group with an absolute risk increase for death at 180 days of 5.9% (95% CI: 3.6–8.3; P< 0.001). Low-grade RBC-transfusion was also associated with renal, circulatory, and respiratory failure as well as a higher SOFA-max score. Sensitivity analyses suggested that disease trajectories during the exposure time did not significantly differ between the groups. Conclusions: Low-grade RBC-transfusions given to non-septic critically ill patients without significant anaemia were associated with increased mortality, increased kidney, circulatory, and respiratory failure, as well as higher SOFA-max score.</p>}},
author = {{Kander, Thomas and Nilsson, Caroline U. and Larsson, Daniel and Bentzer, Peter}},
issn = {{1642-5758}},
keywords = {{Blood transfusion; Circulatory failure; Days alive and free; Erythrocyte transfusion; Mortality; Renal failure; Respiratory failure}},
language = {{eng}},
number = {{5}},
pages = {{390--397}},
publisher = {{Via Medica}},
series = {{Anaesthesiology Intensive Therapy}},
title = {{Effects of red blood cell transfusions given to non-septic critically ill patients : a propensity score matched study}},
url = {{http://dx.doi.org/10.5114/ait.2021.111739}},
doi = {{10.5114/ait.2021.111739}},
volume = {{53}},
year = {{2021}},
}