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Prenatal Gyrification Pattern Affects Age at Onset in Frontotemporal Dementia

Harper, Luke LU ; Lindberg, Olof ; Bocchetta, Martina ; Todd, Emily G ; Strandberg, Olof LU ; van Westen, Danielle LU orcid ; Stomrud, Erik LU orcid ; Landqvist Waldö, Maria LU ; Wahlund, Lars-Olof and Hansson, Oskar LU orcid , et al. (2022) In Cerebral Cortex 32(18). p.3937-3944
Abstract

The paracingulate sulcus is a tertiary sulcus formed during the third trimester. In healthy individuals paracingulate sulcation is more prevalent in the left hemisphere. The anterior cingulate and paracingulate gyri are focal points of neurodegeneration in behavioral variant frontotemporal dementia (bvFTD). This study aims to determine the prevalence and impact of paracingulate sulcation in bvFTD. Structural magnetic resonance images of individuals with bvFTD (n = 105, mean age 66.9 years), Alzheimer's disease (n = 92, 73.3), and healthy controls (n = 110, 62.4) were evaluated using standard protocol for hemispheric paracingulate sulcal presence. No difference in left hemisphere paracingulate sulcal frequency was observed between... (More)

The paracingulate sulcus is a tertiary sulcus formed during the third trimester. In healthy individuals paracingulate sulcation is more prevalent in the left hemisphere. The anterior cingulate and paracingulate gyri are focal points of neurodegeneration in behavioral variant frontotemporal dementia (bvFTD). This study aims to determine the prevalence and impact of paracingulate sulcation in bvFTD. Structural magnetic resonance images of individuals with bvFTD (n = 105, mean age 66.9 years), Alzheimer's disease (n = 92, 73.3), and healthy controls (n = 110, 62.4) were evaluated using standard protocol for hemispheric paracingulate sulcal presence. No difference in left hemisphere paracingulate sulcal frequency was observed between groups; 0.72, 0.79, and 0.70, respectively, in the bvFTD, Alzheimer's disease, and healthy control groups, (P = 0.3). A significant impact of right (but not left) hemispheric paracingulate sulcation on age at disease onset was identified in bvFTD (mean 60.4 years where absent vs. 63.8 where present [P = 0.04, Cohen's d = 0.42]). This relationship was not observed in Alzheimer's disease. These findings demonstrate a relationship between prenatal neuronal development and the expression of a neurodegenerative disease providing a gross morphological example of brain reserve.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cerebral Cortex
volume
32
issue
18
pages
3937 - 3944
publisher
Oxford University Press
external identifiers
  • pmid:35034126
  • scopus:85135618024
ISSN
1460-2199
DOI
10.1093/cercor/bhab457
language
English
LU publication?
yes
additional info
© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
id
3fb2ec61-20ff-403e-9b65-b83744bec3e1
date added to LUP
2022-03-04 13:19:46
date last changed
2024-06-15 00:41:09
@article{3fb2ec61-20ff-403e-9b65-b83744bec3e1,
  abstract     = {{<p>The paracingulate sulcus is a tertiary sulcus formed during the third trimester. In healthy individuals paracingulate sulcation is more prevalent in the left hemisphere. The anterior cingulate and paracingulate gyri are focal points of neurodegeneration in behavioral variant frontotemporal dementia (bvFTD). This study aims to determine the prevalence and impact of paracingulate sulcation in bvFTD. Structural magnetic resonance images of individuals with bvFTD (n = 105, mean age 66.9 years), Alzheimer's disease (n = 92, 73.3), and healthy controls (n = 110, 62.4) were evaluated using standard protocol for hemispheric paracingulate sulcal presence. No difference in left hemisphere paracingulate sulcal frequency was observed between groups; 0.72, 0.79, and 0.70, respectively, in the bvFTD, Alzheimer's disease, and healthy control groups, (P = 0.3). A significant impact of right (but not left) hemispheric paracingulate sulcation on age at disease onset was identified in bvFTD (mean 60.4 years where absent vs. 63.8 where present [P = 0.04, Cohen's d = 0.42]). This relationship was not observed in Alzheimer's disease. These findings demonstrate a relationship between prenatal neuronal development and the expression of a neurodegenerative disease providing a gross morphological example of brain reserve.</p>}},
  author       = {{Harper, Luke and Lindberg, Olof and Bocchetta, Martina and Todd, Emily G and Strandberg, Olof and van Westen, Danielle and Stomrud, Erik and Landqvist Waldö, Maria and Wahlund, Lars-Olof and Hansson, Oskar and Rohrer, Jonathan D and Santillo, Alexander}},
  issn         = {{1460-2199}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{18}},
  pages        = {{3937--3944}},
  publisher    = {{Oxford University Press}},
  series       = {{Cerebral Cortex}},
  title        = {{Prenatal Gyrification Pattern Affects Age at Onset in Frontotemporal Dementia}},
  url          = {{http://dx.doi.org/10.1093/cercor/bhab457}},
  doi          = {{10.1093/cercor/bhab457}},
  volume       = {{32}},
  year         = {{2022}},
}