The analgesic effect of oxygen during percutaneous coronary intervention (the OXYPAIN Trial).
(2013) In Acute Cardiac Care 15(3). p.63-68- Abstract
- Abstract Introduction: Oxygen is considered to have analgesic effects, but the evidence is weak. Oxygen may be harmful to the ischemic myocardium. The aim was to investigate the analgesic effect of oxygen during percutaneous coronary intervention (PCI) and to evaluate cardiac injury. Material and methods: The OXYPAIN was a phase II randomized trial with a double blind design. 305 patients were randomized to receive oxygen or atmospheric air during PCI. The patients were asked to score chest pain by the Visual-Analog Scale (VAS). The use of analgesic agents and troponin-t was measured. Results: There was no significant difference in pain between the groups: oxygen: 2.0, [2.0-4.0], air: 2.0, [2.0-5.0] (median, interquartile range: 25-75%, P... (More)
- Abstract Introduction: Oxygen is considered to have analgesic effects, but the evidence is weak. Oxygen may be harmful to the ischemic myocardium. The aim was to investigate the analgesic effect of oxygen during percutaneous coronary intervention (PCI) and to evaluate cardiac injury. Material and methods: The OXYPAIN was a phase II randomized trial with a double blind design. 305 patients were randomized to receive oxygen or atmospheric air during PCI. The patients were asked to score chest pain by the Visual-Analog Scale (VAS). The use of analgesic agents and troponin-t was measured. Results: There was no significant difference in pain between the groups: oxygen: 2.0, [2.0-4.0], air: 2.0, [2.0-5.0] (median, interquartile range: 25-75%, P = 0.12). The median difference in score of VAS was [95% CI]: 0, [0-1.0]. The oxygen group received 0.44 ± 0.11 mg of morphine versus 0.46 ± 0.13, P = n.s. The peak value of troponin-t post-PCI was 38, [11-352] nmol/ml in the oxygen group and 61, [16-241] for patients treated with air, P = 0.46. Conclusions: The use of oxygen during PCI did not demonstrate any analgesic effect. There was no difference in myocardial injury measured with troponin-t or in the morphine dose. Our results do not support routine use of oxygen. (NCT01413841.). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4005537
- author
- Sparv, David LU ; Bhiladvala, Pallonji LU ; Van Dijkman, Anna ; Harnek, Jan LU ; Madsen-Härdig, Bjarne LU ; Björk, Jonas LU ; Ekelund, Ulf LU and Erlinge, David LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acute Cardiac Care
- volume
- 15
- issue
- 3
- pages
- 63 - 68
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:23957447
- scopus:84883033838
- pmid:23957447
- ISSN
- 1748-2941
- DOI
- 10.3109/17482941.2013.822083
- language
- English
- LU publication?
- yes
- id
- 84100a40-38c0-42d3-aa49-ba435398a579 (old id 4005537)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23957447?dopt=Abstract
- date added to LUP
- 2016-04-01 10:51:59
- date last changed
- 2024-01-07 02:57:12
@article{84100a40-38c0-42d3-aa49-ba435398a579, abstract = {{Abstract Introduction: Oxygen is considered to have analgesic effects, but the evidence is weak. Oxygen may be harmful to the ischemic myocardium. The aim was to investigate the analgesic effect of oxygen during percutaneous coronary intervention (PCI) and to evaluate cardiac injury. Material and methods: The OXYPAIN was a phase II randomized trial with a double blind design. 305 patients were randomized to receive oxygen or atmospheric air during PCI. The patients were asked to score chest pain by the Visual-Analog Scale (VAS). The use of analgesic agents and troponin-t was measured. Results: There was no significant difference in pain between the groups: oxygen: 2.0, [2.0-4.0], air: 2.0, [2.0-5.0] (median, interquartile range: 25-75%, P = 0.12). The median difference in score of VAS was [95% CI]: 0, [0-1.0]. The oxygen group received 0.44 ± 0.11 mg of morphine versus 0.46 ± 0.13, P = n.s. The peak value of troponin-t post-PCI was 38, [11-352] nmol/ml in the oxygen group and 61, [16-241] for patients treated with air, P = 0.46. Conclusions: The use of oxygen during PCI did not demonstrate any analgesic effect. There was no difference in myocardial injury measured with troponin-t or in the morphine dose. Our results do not support routine use of oxygen. (NCT01413841.).}}, author = {{Sparv, David and Bhiladvala, Pallonji and Van Dijkman, Anna and Harnek, Jan and Madsen-Härdig, Bjarne and Björk, Jonas and Ekelund, Ulf and Erlinge, David}}, issn = {{1748-2941}}, language = {{eng}}, number = {{3}}, pages = {{63--68}}, publisher = {{Taylor & Francis}}, series = {{Acute Cardiac Care}}, title = {{The analgesic effect of oxygen during percutaneous coronary intervention (the OXYPAIN Trial).}}, url = {{https://lup.lub.lu.se/search/files/2197889/4402385.pdf}}, doi = {{10.3109/17482941.2013.822083}}, volume = {{15}}, year = {{2013}}, }