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Faster progression to AIDS and AIDS-related death among seroincident individuals infected with recombinant HIV-1 A3/CRF02_AG compared to sub subtype A3.

Palm, Angelica LU ; Esbjörnsson, Joakim LU ; Månsson, Fredrik LU ; Kvist, Anders LU ; Isberg, Per-Erik LU ; Biague, Antonio; da Silva, Zacarias José; Jansson, Marianne LU ; Norrgren, Hans LU and Medstrand, Patrik LU (2014) In Journal of Infectious Diseases 209(5). p.721-728
Abstract
HIV-1 is divided into different subtypes and circulating recombinant forms (CRFs) but the impact of HIV-1 subtype/CRF on disease progression is not fully understood. We determined the HIV-1 subtype/CRF of 152 seroincident individuals from Guinea-Bissau, based on the C2-V3 region of env. Rate of disease progression was measured as time from estimated seroconversion to AIDS and AIDS-related death. Hazard ratios (HRs) were calculated using a Cox proportional hazard model, adjusting for gender and age at seroconversion. The major subtypes/CRFs identified were CRF02_AG (53%), A3 (29%) and A3/02 (a recombinant of A3 and CRF02_AG) (13%). Infection with A3/02 was associated with a close to 3-fold increased risk of AIDS and AIDS-related death... (More)
HIV-1 is divided into different subtypes and circulating recombinant forms (CRFs) but the impact of HIV-1 subtype/CRF on disease progression is not fully understood. We determined the HIV-1 subtype/CRF of 152 seroincident individuals from Guinea-Bissau, based on the C2-V3 region of env. Rate of disease progression was measured as time from estimated seroconversion to AIDS and AIDS-related death. Hazard ratios (HRs) were calculated using a Cox proportional hazard model, adjusting for gender and age at seroconversion. The major subtypes/CRFs identified were CRF02_AG (53%), A3 (29%) and A3/02 (a recombinant of A3 and CRF02_AG) (13%). Infection with A3/02 was associated with a close to 3-fold increased risk of AIDS and AIDS-related death compared to A3 (HR=2.6 [P=0.011] and 2.9 [P=0.032], respectively). The median estimated time from seroconversion to AIDS and AIDS-related death was 5.0 and 8.0 years for A3/02, 6.2 and 9.0 years for CRF02_AG and 7.2 and 11.3 years for A3. Our results show that there are significant differences in disease progression between HIV-1 A-like subtypes/CRFs. Individuals infected with the A3/02 recombinant have among the fastest progression rates to AIDS reported to date. Determining the HIV-1 subtype of infected individuals could be of importance in the management of HIV-1 infections. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
209
issue
5
pages
721 - 728
publisher
Oxford University Press
external identifiers
  • pmid:23935204
  • wos:000331873700012
  • scopus:84894091039
ISSN
1537-6613
DOI
10.1093/infdis/jit416
language
English
LU publication?
yes
id
8b5f32aa-b6e4-4c72-abcf-a55339344d5b (old id 4005914)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23935204?dopt=Abstract
date added to LUP
2013-09-03 15:16:53
date last changed
2017-10-22 03:28:00
@article{8b5f32aa-b6e4-4c72-abcf-a55339344d5b,
  abstract     = {HIV-1 is divided into different subtypes and circulating recombinant forms (CRFs) but the impact of HIV-1 subtype/CRF on disease progression is not fully understood. We determined the HIV-1 subtype/CRF of 152 seroincident individuals from Guinea-Bissau, based on the C2-V3 region of env. Rate of disease progression was measured as time from estimated seroconversion to AIDS and AIDS-related death. Hazard ratios (HRs) were calculated using a Cox proportional hazard model, adjusting for gender and age at seroconversion. The major subtypes/CRFs identified were CRF02_AG (53%), A3 (29%) and A3/02 (a recombinant of A3 and CRF02_AG) (13%). Infection with A3/02 was associated with a close to 3-fold increased risk of AIDS and AIDS-related death compared to A3 (HR=2.6 [P=0.011] and 2.9 [P=0.032], respectively). The median estimated time from seroconversion to AIDS and AIDS-related death was 5.0 and 8.0 years for A3/02, 6.2 and 9.0 years for CRF02_AG and 7.2 and 11.3 years for A3. Our results show that there are significant differences in disease progression between HIV-1 A-like subtypes/CRFs. Individuals infected with the A3/02 recombinant have among the fastest progression rates to AIDS reported to date. Determining the HIV-1 subtype of infected individuals could be of importance in the management of HIV-1 infections.},
  author       = {Palm, Angelica and Esbjörnsson, Joakim and Månsson, Fredrik and Kvist, Anders and Isberg, Per-Erik and Biague, Antonio and da Silva, Zacarias José and Jansson, Marianne and Norrgren, Hans and Medstrand, Patrik},
  issn         = {1537-6613},
  language     = {eng},
  number       = {5},
  pages        = {721--728},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Faster progression to AIDS and AIDS-related death among seroincident individuals infected with recombinant HIV-1 A3/CRF02_AG compared to sub subtype A3.},
  url          = {http://dx.doi.org/10.1093/infdis/jit416},
  volume       = {209},
  year         = {2014},
}