Faster progression to AIDS and AIDS-related death among seroincident individuals infected with recombinant HIV-1 A3/CRF02_AG compared to sub subtype A3.
Palm, Angelica LU ; Esbjörnsson, Joakim LU
; Månsson, Fredrik
LU
; Kvist, Anders
LU
; Isberg, Per-Erik
LU
; Biague, Antonio
; da Silva, Zacarias José
; Jansson, Marianne
LU
; Norrgren, Hans
LU
and Medstrand, Patrik
LU
(2014)
In Journal of Infectious Diseases
209(5).
p.721-728
- Abstract
- HIV-1 is divided into different subtypes and circulating recombinant forms (CRFs) but the impact of HIV-1 subtype/CRF on disease progression is not fully understood. We determined the HIV-1 subtype/CRF of 152 seroincident individuals from Guinea-Bissau, based on the C2-V3 region of env. Rate of disease progression was measured as time from estimated seroconversion to AIDS and AIDS-related death. Hazard ratios (HRs) were calculated using a Cox proportional hazard model, adjusting for gender and age at seroconversion. The major subtypes/CRFs identified were CRF02_AG (53%), A3 (29%) and A3/02 (a recombinant of A3 and CRF02_AG) (13%). Infection with A3/02 was associated with a close to 3-fold increased risk of AIDS and AIDS-related death... (More)
- HIV-1 is divided into different subtypes and circulating recombinant forms (CRFs) but the impact of HIV-1 subtype/CRF on disease progression is not fully understood. We determined the HIV-1 subtype/CRF of 152 seroincident individuals from Guinea-Bissau, based on the C2-V3 region of env. Rate of disease progression was measured as time from estimated seroconversion to AIDS and AIDS-related death. Hazard ratios (HRs) were calculated using a Cox proportional hazard model, adjusting for gender and age at seroconversion. The major subtypes/CRFs identified were CRF02_AG (53%), A3 (29%) and A3/02 (a recombinant of A3 and CRF02_AG) (13%). Infection with A3/02 was associated with a close to 3-fold increased risk of AIDS and AIDS-related death compared to A3 (HR=2.6 [P=0.011] and 2.9 [P=0.032], respectively). The median estimated time from seroconversion to AIDS and AIDS-related death was 5.0 and 8.0 years for A3/02, 6.2 and 9.0 years for CRF02_AG and 7.2 and 11.3 years for A3. Our results show that there are significant differences in disease progression between HIV-1 A-like subtypes/CRFs. Individuals infected with the A3/02 recombinant have among the fastest progression rates to AIDS reported to date. Determining the HIV-1 subtype of infected individuals could be of importance in the management of HIV-1 infections. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4005914
- author
- Palm, Angelica
LU
; Esbjörnsson, Joakim
LU
; Månsson, Fredrik
LU
; Kvist, Anders
LU
; Isberg, Per-Erik
LU
; Biague, Antonio
; da Silva, Zacarias José
; Jansson, Marianne
LU
; Norrgren, Hans
LU
and Medstrand, Patrik
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Infectious Diseases
- volume
- 209
- issue
- 5
- pages
- 721 - 728
- publisher
- Oxford University Press
- external identifiers
-
- pmid:23935204
- wos:000331873700012
- scopus:84894091039
- pmid:23935204
- ISSN
- 1537-6613
- DOI
- 10.1093/infdis/jit416
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Infectious Diseases Research Unit (013242010), Virology (013017520), Division of Infection Medicine (SUS) (013008000), Oncology, MV (013035000), Department of Statistics (012014000), Division of Medical Microbiology (013250400), Clinical Virology, Malmö (013017580), Division of Hematology and Transfusion Medicine (013041100)
- id
- 8b5f32aa-b6e4-4c72-abcf-a55339344d5b (old id 4005914)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23935204?dopt=Abstract
- date added to LUP
- 2016-04-01 11:02:48
- date last changed
- 2024-11-19 00:05:23
@article{8b5f32aa-b6e4-4c72-abcf-a55339344d5b,
abstract = {{HIV-1 is divided into different subtypes and circulating recombinant forms (CRFs) but the impact of HIV-1 subtype/CRF on disease progression is not fully understood. We determined the HIV-1 subtype/CRF of 152 seroincident individuals from Guinea-Bissau, based on the C2-V3 region of env. Rate of disease progression was measured as time from estimated seroconversion to AIDS and AIDS-related death. Hazard ratios (HRs) were calculated using a Cox proportional hazard model, adjusting for gender and age at seroconversion. The major subtypes/CRFs identified were CRF02_AG (53%), A3 (29%) and A3/02 (a recombinant of A3 and CRF02_AG) (13%). Infection with A3/02 was associated with a close to 3-fold increased risk of AIDS and AIDS-related death compared to A3 (HR=2.6 [P=0.011] and 2.9 [P=0.032], respectively). The median estimated time from seroconversion to AIDS and AIDS-related death was 5.0 and 8.0 years for A3/02, 6.2 and 9.0 years for CRF02_AG and 7.2 and 11.3 years for A3. Our results show that there are significant differences in disease progression between HIV-1 A-like subtypes/CRFs. Individuals infected with the A3/02 recombinant have among the fastest progression rates to AIDS reported to date. Determining the HIV-1 subtype of infected individuals could be of importance in the management of HIV-1 infections.}},
author = {{Palm, Angelica and Esbjörnsson, Joakim and Månsson, Fredrik and Kvist, Anders and Isberg, Per-Erik and Biague, Antonio and da Silva, Zacarias José and Jansson, Marianne and Norrgren, Hans and Medstrand, Patrik}},
issn = {{1537-6613}},
language = {{eng}},
number = {{5}},
pages = {{721--728}},
publisher = {{Oxford University Press}},
series = {{Journal of Infectious Diseases}},
title = {{Faster progression to AIDS and AIDS-related death among seroincident individuals infected with recombinant HIV-1 A3/CRF02_AG compared to sub subtype A3.}},
url = {{http://dx.doi.org/10.1093/infdis/jit416}},
doi = {{10.1093/infdis/jit416}},
volume = {{209}},
year = {{2014}},
}