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Health-related quality of life in multiple system atrophy

Schrag, A ; Geser, F ; Stampfer-Kountchev, M ; Seppi, K ; Sawires, M ; Kollensperger, M ; Scherfler, C ; Quinn, N ; Pellecchia, MT and Barone, P , et al. (2006) In Movement Disorders 21(6). p.809-815
Abstract
Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-513, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale... (More)
Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-513, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI >= 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease. (c) 2006 Movement Disorder Society. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
health-related quality of life, multiple system atrophy, autonomic dysfunction, depression
in
Movement Disorders
volume
21
issue
6
pages
809 - 815
publisher
John Wiley and Sons Inc.
external identifiers
  • pmid:16502399
  • wos:000238560700012
  • scopus:33745869469
ISSN
0885-3185
DOI
10.1002/mds.20808
language
English
LU publication?
yes
id
1a6c1a35-7c9d-44fd-bbd7-aeeaa419be59 (old id 404793)
date added to LUP
2016-04-01 11:42:23
date last changed
2020-10-07 02:19:21
@article{1a6c1a35-7c9d-44fd-bbd7-aeeaa419be59,
  abstract     = {Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-513, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI >= 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease. (c) 2006 Movement Disorder Society.},
  author       = {Schrag, A and Geser, F and Stampfer-Kountchev, M and Seppi, K and Sawires, M and Kollensperger, M and Scherfler, C and Quinn, N and Pellecchia, MT and Barone, P and del Sorbo, F and Albanese, A and Ostergaard, K and Dupont, E and Cardozo, A and Tolosa, E and Nilsson, C and Widner, Håkan and Lindvall, Olle and Giladi, N and Gurevich, T and Daniels, C and Deuschl, G and Coelho, M and Sampaio, C and Abele, M and Klockgether, T and Schimke, N and Eggert, KM and Oertel, W and Djaldetti, R and Colosimo, C and Meco, G and Poewe, W and Wenning, GK},
  issn         = {0885-3185},
  language     = {eng},
  number       = {6},
  pages        = {809--815},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Movement Disorders},
  title        = {Health-related quality of life in multiple system atrophy},
  url          = {http://dx.doi.org/10.1002/mds.20808},
  doi          = {10.1002/mds.20808},
  volume       = {21},
  year         = {2006},
}