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The islet ghrelin cell.

Wierup, Nils LU ; Sundler, Frank LU and Heller, Scott (2014) In Journal of Molecular Endocrinology 52(1). p.35-49
Abstract
The islets of Langerhans are key regulators of glucose homeostasis and have been known as a structure for almost one and a half centurys now. During the twentieth century several different cell types were described in the islets of different species and at different developmental stages. Six cell types with identified hormonal product have been described so far by the use of histochemical staining methods, transmission electron microscopy, and immunohistochemistry. Thus, glucagon-producing alpha-cells, insulin-producing beta-cells, somatostatin-producing delta-cells, pancreatic polypeptide-producing PP-cells, Serotonin-producing EC-cells, and gastrin-producing G-cells have all been found in the mammalian pancreas at least at some... (More)
The islets of Langerhans are key regulators of glucose homeostasis and have been known as a structure for almost one and a half centurys now. During the twentieth century several different cell types were described in the islets of different species and at different developmental stages. Six cell types with identified hormonal product have been described so far by the use of histochemical staining methods, transmission electron microscopy, and immunohistochemistry. Thus, glucagon-producing alpha-cells, insulin-producing beta-cells, somatostatin-producing delta-cells, pancreatic polypeptide-producing PP-cells, Serotonin-producing EC-cells, and gastrin-producing G-cells have all been found in the mammalian pancreas at least at some developmental stage. Species differences are at hand and age-related differences are also to be considered. Eleven years ago a novel cell type, the ghrelin cell, was discovered in the human islets. Subsequent studies have shown the presence of islet ghrelin cells in several animals, including mouse, rat, gerbils, and fish. The developmental regulation of ghrelin cells in the islets of mice has gained a lot of interest and several studies have added important pieces to the puzzle of molecular mechanisms and the genetic regulation that lead to differentiation into mature ghrelin cells. A body of evidence has shown that ghrelin is an insulinostatic hormone, and the potential for blockade of ghrelin signalling as a therapeutic avenue for type 2 diabetes is intriguing. Furthermore, ghrelin expressing pancreatic tumours have been reported and ghrelin needs to be taken into account when diagnosing pancreatic tumours. In this review article we summarize the knowledge about islet ghrelin cells obtained so far. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Molecular Endocrinology
volume
52
issue
1
pages
35 - 49
publisher
Society for Endocrinology
external identifiers
  • pmid:24049065
  • wos:000334278000004
  • scopus:84890869288
ISSN
1479-6813
DOI
10.1530/JME-13-0122
language
English
LU publication?
yes
id
d38248dc-415a-45c3-90a2-1a8c0b8f3c78 (old id 4065630)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24049065?dopt=Abstract
date added to LUP
2013-10-03 20:12:10
date last changed
2017-11-05 03:21:59
@article{d38248dc-415a-45c3-90a2-1a8c0b8f3c78,
  abstract     = {The islets of Langerhans are key regulators of glucose homeostasis and have been known as a structure for almost one and a half centurys now. During the twentieth century several different cell types were described in the islets of different species and at different developmental stages. Six cell types with identified hormonal product have been described so far by the use of histochemical staining methods, transmission electron microscopy, and immunohistochemistry. Thus, glucagon-producing alpha-cells, insulin-producing beta-cells, somatostatin-producing delta-cells, pancreatic polypeptide-producing PP-cells, Serotonin-producing EC-cells, and gastrin-producing G-cells have all been found in the mammalian pancreas at least at some developmental stage. Species differences are at hand and age-related differences are also to be considered. Eleven years ago a novel cell type, the ghrelin cell, was discovered in the human islets. Subsequent studies have shown the presence of islet ghrelin cells in several animals, including mouse, rat, gerbils, and fish. The developmental regulation of ghrelin cells in the islets of mice has gained a lot of interest and several studies have added important pieces to the puzzle of molecular mechanisms and the genetic regulation that lead to differentiation into mature ghrelin cells. A body of evidence has shown that ghrelin is an insulinostatic hormone, and the potential for blockade of ghrelin signalling as a therapeutic avenue for type 2 diabetes is intriguing. Furthermore, ghrelin expressing pancreatic tumours have been reported and ghrelin needs to be taken into account when diagnosing pancreatic tumours. In this review article we summarize the knowledge about islet ghrelin cells obtained so far.},
  author       = {Wierup, Nils and Sundler, Frank and Heller, Scott},
  issn         = {1479-6813},
  language     = {eng},
  number       = {1},
  pages        = {35--49},
  publisher    = {Society for Endocrinology},
  series       = {Journal of Molecular Endocrinology},
  title        = {The islet ghrelin cell.},
  url          = {http://dx.doi.org/10.1530/JME-13-0122},
  volume       = {52},
  year         = {2014},
}