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From starch to starch microspheres: Factors controlling the microspheres quality

Elfstrand, Lidia LU ; Eliasson, Ann-Charlotte LU ; Jönsson, Monica LU ; Reslow, Mats and Wahlgren, Marie LU (2006) In Stärke 58(8). p.381-390
Abstract
Starch microparticle is a dosage form suitable for encapsulation of protein drugs. The microparticle characteristics can be influential factors for consecutive sustained drug release from the starch matrix and impact its ability to be coated by poly(D,L-lactide-co-glycolide). In this study, six types of starch microparticles were investigated and characterized. Desired qualities of the microspheres such as spherical form of the particles, well-defined and sharp particle contours were coincident with coarse surface morphology, sharp and distinct peaks in DSC and X-ray graphs. It was concluded that the quality of the starch microparticles was influenced by molecular properties of the starch material as well as type of buffer, and these... (More)
Starch microparticle is a dosage form suitable for encapsulation of protein drugs. The microparticle characteristics can be influential factors for consecutive sustained drug release from the starch matrix and impact its ability to be coated by poly(D,L-lactide-co-glycolide). In this study, six types of starch microparticles were investigated and characterized. Desired qualities of the microspheres such as spherical form of the particles, well-defined and sharp particle contours were coincident with coarse surface morphology, sharp and distinct peaks in DSC and X-ray graphs. It was concluded that the quality of the starch microparticles was influenced by molecular properties of the starch material as well as type of buffer, and these factors were related to recrystallization kinetics, amount and quality of ordered/crystalline structure of final starch microspheres and their microscopic appearance. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
quality, product, microscopic appearance, starch microspheres, crystallinity
in
Stärke
volume
58
issue
8
pages
381 - 390
publisher
John Wiley & Sons
external identifiers
  • wos:000240259700001
  • scopus:33748454859
ISSN
0038-9056
DOI
10.1002/star.200600489
language
English
LU publication?
yes
id
40c18d03-ba2c-423f-bb24-8940b4bdcb7e (old id 394305)
date added to LUP
2007-08-29 10:32:24
date last changed
2019-03-25 02:17:11
@article{40c18d03-ba2c-423f-bb24-8940b4bdcb7e,
  abstract     = {Starch microparticle is a dosage form suitable for encapsulation of protein drugs. The microparticle characteristics can be influential factors for consecutive sustained drug release from the starch matrix and impact its ability to be coated by poly(D,L-lactide-co-glycolide). In this study, six types of starch microparticles were investigated and characterized. Desired qualities of the microspheres such as spherical form of the particles, well-defined and sharp particle contours were coincident with coarse surface morphology, sharp and distinct peaks in DSC and X-ray graphs. It was concluded that the quality of the starch microparticles was influenced by molecular properties of the starch material as well as type of buffer, and these factors were related to recrystallization kinetics, amount and quality of ordered/crystalline structure of final starch microspheres and their microscopic appearance.},
  author       = {Elfstrand, Lidia and Eliasson, Ann-Charlotte and Jönsson, Monica and Reslow, Mats and Wahlgren, Marie},
  issn         = {0038-9056},
  keyword      = {quality,product,microscopic appearance,starch microspheres,crystallinity},
  language     = {eng},
  number       = {8},
  pages        = {381--390},
  publisher    = {John Wiley & Sons},
  series       = {Stärke},
  title        = {From starch to starch microspheres: Factors controlling the microspheres quality},
  url          = {http://dx.doi.org/10.1002/star.200600489},
  volume       = {58},
  year         = {2006},
}