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Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease

Björkqvist, Maria LU ; Petersén, Åsa LU ; Bacos, Karl LU orcid ; Isaacs, J ; Norlén, Per LU ; Gil, Joana ; Popovic, Natalija ; Sundler, Frank LU ; Bates, GP and Tabrizi, SJ , et al. (2006) In Human Molecular Genetics 15(10). p.1713-1721
Abstract
Huntington's disease (HD) is characterized by a triad of motor, psychiatric and cognitive symptoms. Although many of these symptoms are likely to be related to central nervous system pathology, others may be due to changes in peripheral tissues. The R6/2 mouse, a transgenic model of HD expressing exon 1 of the human HD gene, develops progressive alterations in the hypothalamic-pituitary-adrenal axis, reminiscent of a Cushing-like syndrome. We observed muscular atrophy, reduced bone mineral density, abdominal fat accumulation and insulin resistance in the mice. All these changes could be consequences of increased glucocorticoid levels. Indeed, hypertrophy of the adrenal cortex and a progressive increase in serum and urine corticosterone... (More)
Huntington's disease (HD) is characterized by a triad of motor, psychiatric and cognitive symptoms. Although many of these symptoms are likely to be related to central nervous system pathology, others may be due to changes in peripheral tissues. The R6/2 mouse, a transgenic model of HD expressing exon 1 of the human HD gene, develops progressive alterations in the hypothalamic-pituitary-adrenal axis, reminiscent of a Cushing-like syndrome. We observed muscular atrophy, reduced bone mineral density, abdominal fat accumulation and insulin resistance in the mice. All these changes could be consequences of increased glucocorticoid levels. Indeed, hypertrophy of the adrenal cortex and a progressive increase in serum and urine corticosterone levels were found in R6/2 mice. In addition, the intermediate pituitary lobe was markedly enlarged and circulating adreno-corticotrophic hormone (ACTH) increased. Under normal conditions dopamine represses the ACTH expression. In the R6/2 mice, however, the expression of pituitary dopamine D2 receptors was reduced by half, possibly explaining the increase in ACTH. Urinary samples from 82 HD patients and 68 control subjects were analysed for cortisol: in accord with the observations in the R6/2 mice, urinary cortisol increased in parallel with disease progression. This progressive increase in cortisol may contribute to the clinical symptoms, such as muscular wasting, mood changes and some of the cognitive deficits that occur in HD. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Human Molecular Genetics
volume
15
issue
10
pages
1713 - 1721
publisher
Oxford University Press
external identifiers
  • wos:000237320200016
  • pmid:16613897
  • scopus:33745210300
  • pmid:16613897
ISSN
0964-6906
DOI
10.1093/hmg/ddl094
language
English
LU publication?
yes
id
fe2da657-1c9f-480f-934c-55480d0b219a (old id 410087)
date added to LUP
2016-04-01 12:02:56
date last changed
2021-10-06 01:58:58
@article{fe2da657-1c9f-480f-934c-55480d0b219a,
  abstract     = {Huntington's disease (HD) is characterized by a triad of motor, psychiatric and cognitive symptoms. Although many of these symptoms are likely to be related to central nervous system pathology, others may be due to changes in peripheral tissues. The R6/2 mouse, a transgenic model of HD expressing exon 1 of the human HD gene, develops progressive alterations in the hypothalamic-pituitary-adrenal axis, reminiscent of a Cushing-like syndrome. We observed muscular atrophy, reduced bone mineral density, abdominal fat accumulation and insulin resistance in the mice. All these changes could be consequences of increased glucocorticoid levels. Indeed, hypertrophy of the adrenal cortex and a progressive increase in serum and urine corticosterone levels were found in R6/2 mice. In addition, the intermediate pituitary lobe was markedly enlarged and circulating adreno-corticotrophic hormone (ACTH) increased. Under normal conditions dopamine represses the ACTH expression. In the R6/2 mice, however, the expression of pituitary dopamine D2 receptors was reduced by half, possibly explaining the increase in ACTH. Urinary samples from 82 HD patients and 68 control subjects were analysed for cortisol: in accord with the observations in the R6/2 mice, urinary cortisol increased in parallel with disease progression. This progressive increase in cortisol may contribute to the clinical symptoms, such as muscular wasting, mood changes and some of the cognitive deficits that occur in HD.},
  author       = {Björkqvist, Maria and Petersén, Åsa and Bacos, Karl and Isaacs, J and Norlén, Per and Gil, Joana and Popovic, Natalija and Sundler, Frank and Bates, GP and Tabrizi, SJ and Brundin, Patrik and Mulder, Hindrik},
  issn         = {0964-6906},
  language     = {eng},
  number       = {10},
  pages        = {1713--1721},
  publisher    = {Oxford University Press},
  series       = {Human Molecular Genetics},
  title        = {Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease},
  url          = {http://dx.doi.org/10.1093/hmg/ddl094},
  doi          = {10.1093/hmg/ddl094},
  volume       = {15},
  year         = {2006},
}