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Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease.

Werner, Karin LU ; Elmståhl, Sölve LU ; Christensson, Anders LU and Pihlsgård, Mats LU (2014) In Age and Ageing 43(3). p.411-417
Abstract
Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes.Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population.Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931.Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or... (More)
Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes.Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population.Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931.Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both.Results: the median for plasma cystatin C was 0.93 mg/l (60-69 years old), 1.04 (70-79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR < 60 ml/min/1.73 m(2).Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR < 60 ml/min/1.73 m(2). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Age and Ageing
volume
43
issue
3
pages
411 - 417
publisher
Oxford University Press
external identifiers
  • pmid:24321840
  • wos:000335770900023
  • scopus:84901981173
ISSN
1468-2834
DOI
10.1093/ageing/aft191
language
English
LU publication?
yes
id
4b10d1c1-fddf-47ad-b1b7-235a6fd2a49c (old id 4224952)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24321840?dopt=Abstract
date added to LUP
2014-01-03 22:05:16
date last changed
2017-01-01 03:12:13
@article{4b10d1c1-fddf-47ad-b1b7-235a6fd2a49c,
  abstract     = {Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes.Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population.Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931.Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both.Results: the median for plasma cystatin C was 0.93 mg/l (60-69 years old), 1.04 (70-79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR &lt; 60 ml/min/1.73 m(2).Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR &lt; 60 ml/min/1.73 m(2).},
  author       = {Werner, Karin and Elmståhl, Sölve and Christensson, Anders and Pihlsgård, Mats},
  issn         = {1468-2834},
  language     = {eng},
  number       = {3},
  pages        = {411--417},
  publisher    = {Oxford University Press},
  series       = {Age and Ageing},
  title        = {Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease.},
  url          = {http://dx.doi.org/10.1093/ageing/aft191},
  volume       = {43},
  year         = {2014},
}