Medial temporal lobe atrophy patterns in early- versus late-onset amnestic Alzheimer's disease
Wuestefeld, Anika LU
; Binette, Alexa Pichet
LU
; van Westen, Danielle
LU
; Strandberg, Olof
LU
; Stomrud, Erik
LU
; Mattsson-Carlgren, Niklas
LU
; Janelidze, Shorena
LU
; Smith, Ruben
LU
; Palmqvist, Sebastian
LU
and Baumeister, Hannah
LU
, et al.
(2024)
In bioRxiv : the preprint server for biology
- Abstract
BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.
METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included. Forty-one EOAD individuals aged ≤65 years and, as comparison, late-onset AD (LOAD, ≥70 years, n=154) and Aβ-negative cognitively unimpaired controls were included. MTL subregions and biomarkers of (co-)pathologies were measured.
RESULTS: AD groups showed smaller MTL subregions compared to controls. Atrophy patterns were similar across AD groups, although LOAD showed thinner entorhinal... (More)
BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.
METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included. Forty-one EOAD individuals aged ≤65 years and, as comparison, late-onset AD (LOAD, ≥70 years, n=154) and Aβ-negative cognitively unimpaired controls were included. MTL subregions and biomarkers of (co-)pathologies were measured.
RESULTS: AD groups showed smaller MTL subregions compared to controls. Atrophy patterns were similar across AD groups, although LOAD showed thinner entorhinal cortices compared to EOAD. EOAD showed lower WMH compared to LOAD. No differences in MTL tau-PET or transactive response DNA binding protein 43-proxy positivity was found.
CONCLUSIONS: We found in vivo evidence for MTL atrophy in amnestic EOAD and overall similar levels to LOAD of MTL tau pathology and co-pathologies.
(Less)
- author
- Wuestefeld, Anika
LU
; Binette, Alexa Pichet
LU
; van Westen, Danielle
LU
; Strandberg, Olof
LU
; Stomrud, Erik
LU
; Mattsson-Carlgren, Niklas
LU
; Janelidze, Shorena
LU
; Smith, Ruben
LU
; Palmqvist, Sebastian
LU
and Baumeister, Hannah
LU
, et al. (More)
- Wuestefeld, Anika
LU
; Binette, Alexa Pichet
LU
; van Westen, Danielle
LU
; Strandberg, Olof
LU
; Stomrud, Erik
LU
; Mattsson-Carlgren, Niklas
LU
; Janelidze, Shorena
LU
; Smith, Ruben
LU
; Palmqvist, Sebastian
LU
; Baumeister, Hannah
LU
; Berron, David
LU
; Yushkevich, Paul A
; Hansson, Oskar
LU
; Spotorno, Nicola
LU
and Wisse, Laura Em
LU
(Less)
- organization
- publishing date
- 2024-05-21
- type
- Working paper/Preprint
- publication status
- published
- subject
- keywords
- tau-PET imaging, amyloid-beta, MRI, medial temporal lobe subregions, aging, in vivo, amnestic AD, early-onset, late-onset, amygdala segmentation protocol, TPD-43
- in
- bioRxiv : the preprint server for biology
- pages
- 32 pages
- external identifiers
-
- pmid:38826333
- ISSN
- 2692-8205
- DOI
- 10.1101/2024.05.21.594976
- language
- English
- LU publication?
- yes
- id
- 424fd864-6bf3-460d-8f50-b5693c0b97b4
- date added to LUP
- 2024-07-05 10:10:11
- date last changed
- 2024-07-05 15:32:42
@misc{424fd864-6bf3-460d-8f50-b5693c0b97b4,
abstract = {{<p>BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.</p><p>METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included. Forty-one EOAD individuals aged ≤65 years and, as comparison, late-onset AD (LOAD, ≥70 years, n=154) and Aβ-negative cognitively unimpaired controls were included. MTL subregions and biomarkers of (co-)pathologies were measured.</p><p>RESULTS: AD groups showed smaller MTL subregions compared to controls. Atrophy patterns were similar across AD groups, although LOAD showed thinner entorhinal cortices compared to EOAD. EOAD showed lower WMH compared to LOAD. No differences in MTL tau-PET or transactive response DNA binding protein 43-proxy positivity was found.</p><p>CONCLUSIONS: We found in vivo evidence for MTL atrophy in amnestic EOAD and overall similar levels to LOAD of MTL tau pathology and co-pathologies.</p>}},
author = {{Wuestefeld, Anika and Binette, Alexa Pichet and van Westen, Danielle and Strandberg, Olof and Stomrud, Erik and Mattsson-Carlgren, Niklas and Janelidze, Shorena and Smith, Ruben and Palmqvist, Sebastian and Baumeister, Hannah and Berron, David and Yushkevich, Paul A and Hansson, Oskar and Spotorno, Nicola and Wisse, Laura Em}},
issn = {{2692-8205}},
keywords = {{tau-PET imaging; amyloid-beta; MRI; medial temporal lobe subregions; aging; in vivo; amnestic AD; early-onset; late-onset; amygdala segmentation protocol; TPD-43}},
language = {{eng}},
month = {{05}},
note = {{Preprint}},
series = {{bioRxiv : the preprint server for biology}},
title = {{Medial temporal lobe atrophy patterns in early- versus late-onset amnestic Alzheimer's disease}},
url = {{http://dx.doi.org/10.1101/2024.05.21.594976}},
doi = {{10.1101/2024.05.21.594976}},
year = {{2024}},
}