Diet quality and change in blood lipids during 16 years of follow-up and their interaction with genetic risk for dyslipidemia
(2016) In Nutrients 8(5).- Abstract
A high diet quality according to the Swedish nutrition recommendations is associated with a reduced risk of cardiovascular disease in the population-based Malmö Diet and Cancer cohort. To further clarify this protective association, we examined the association between high diet quality and change in triglycerides, high density lipoprotein-cholesterol (HDL-C), and low density lipoprotein-cholesterol (LDL-C) after 16 years of follow-up in 3152 individuals (61% women; 46–68 years at baseline). In addition, we examined if genetic risk scores composed of 80 lipid-associated genetic variants modify these associations. A diet quality index based on intakes of saturated fat, polyunsaturated fat, sucrose, fiber, fruit and vegetables, and fish... (More)
A high diet quality according to the Swedish nutrition recommendations is associated with a reduced risk of cardiovascular disease in the population-based Malmö Diet and Cancer cohort. To further clarify this protective association, we examined the association between high diet quality and change in triglycerides, high density lipoprotein-cholesterol (HDL-C), and low density lipoprotein-cholesterol (LDL-C) after 16 years of follow-up in 3152 individuals (61% women; 46–68 years at baseline). In addition, we examined if genetic risk scores composed of 80 lipid-associated genetic variants modify these associations. A diet quality index based on intakes of saturated fat, polyunsaturated fat, sucrose, fiber, fruit and vegetables, and fish was constructed. A high diet quality was associated with lower risk of developing high triglycerides (p = 0.02) and high LDL-C (p = 0.03) during follow-up compared with a low diet quality. We found an association between diet quality and long-term change in HDL-C only among those with lower genetic risk for low HDL-C as opposed to those with higher genetic risk (p-interaction = 0.04). Among those with lower genetic risk for low HDL-C, low diet quality was associated with decreased HDL-C during follow-up (p = 0.05). In conclusion, individuals with high adherence to the Swedish nutrition recommendation had lower risk of developing high triglycerides and LDL-C during 16 years of follow-up.
(Less)
- author
- organization
-
- Diabetes - Cardiovascular Disease (research group)
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- Internal Medicine - Epidemiology (research group)
- Nutrition Epidemiology (research group)
- Cardiovascular Research - Epidemiology (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- publishing date
- 2016-05-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diet, Epidemiology, Genetics, Lipids, Lipoproteins, Nutrition
- in
- Nutrients
- volume
- 8
- issue
- 5
- article number
- 274
- publisher
- MDPI AG
- external identifiers
-
- scopus:84966397439
- wos:000378780900035
- pmid:27171109
- ISSN
- 2072-6643
- DOI
- 10.3390/nu8050274
- project
- Interaction between dietary factors and genetic risk for lipoprotein traits and cardiovascular disease
- language
- English
- LU publication?
- yes
- id
- 42da2ff6-de44-4ece-8e21-ad1137a56629
- date added to LUP
- 2016-06-30 08:30:59
- date last changed
- 2024-06-28 11:52:45
@article{42da2ff6-de44-4ece-8e21-ad1137a56629, abstract = {{<p>A high diet quality according to the Swedish nutrition recommendations is associated with a reduced risk of cardiovascular disease in the population-based Malmö Diet and Cancer cohort. To further clarify this protective association, we examined the association between high diet quality and change in triglycerides, high density lipoprotein-cholesterol (HDL-C), and low density lipoprotein-cholesterol (LDL-C) after 16 years of follow-up in 3152 individuals (61% women; 46–68 years at baseline). In addition, we examined if genetic risk scores composed of 80 lipid-associated genetic variants modify these associations. A diet quality index based on intakes of saturated fat, polyunsaturated fat, sucrose, fiber, fruit and vegetables, and fish was constructed. A high diet quality was associated with lower risk of developing high triglycerides (p = 0.02) and high LDL-C (p = 0.03) during follow-up compared with a low diet quality. We found an association between diet quality and long-term change in HDL-C only among those with lower genetic risk for low HDL-C as opposed to those with higher genetic risk (p-interaction = 0.04). Among those with lower genetic risk for low HDL-C, low diet quality was associated with decreased HDL-C during follow-up (p = 0.05). In conclusion, individuals with high adherence to the Swedish nutrition recommendation had lower risk of developing high triglycerides and LDL-C during 16 years of follow-up.</p>}}, author = {{Sonestedt, Emily and Hellstrand, Sophie and Drake, Isabel and Schulz, Christina Alexandra and Ericson, Ulrika and Hlebowicz, Joanna and Persson, Margaretha M. and Gullberg, Bo and Hedblad, Bo and Engström, Gunnar and Orho-Melander, Marju}}, issn = {{2072-6643}}, keywords = {{Diet; Epidemiology; Genetics; Lipids; Lipoproteins; Nutrition}}, language = {{eng}}, month = {{05}}, number = {{5}}, publisher = {{MDPI AG}}, series = {{Nutrients}}, title = {{Diet quality and change in blood lipids during 16 years of follow-up and their interaction with genetic risk for dyslipidemia}}, url = {{http://dx.doi.org/10.3390/nu8050274}}, doi = {{10.3390/nu8050274}}, volume = {{8}}, year = {{2016}}, }