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The Target for Statins, HMG-CoA Reductase, Is Expressed in Ductal Carcinoma-In Situ and May Predict Patient Response to Radiotherapy.

Butt, Salma LU ; Butt, Talha LU ; Jirström, Karin LU ; Werner Hartman, Linda LU ; Amini, Rose-Marie; Zhou, Wenjing; Wärnberg, Fredrik and Borgquist, Signe LU (2014) In Annals of Surgical Oncology 21(9). p.2911-2919
Abstract
Patients with ductal carcinoma-in-situ (DCIS) are currently not prescribed adjuvant systemic treatment after surgery and radiotherapy. Prediction of DCIS patients who would benefit from radiotherapy is warranted. Statins have been suggested to exert radio-sensitizing effects. The target for cholesterol-lowering statins is HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathway. The aim of this study was to examine HMGCR expression in DCIS and study its treatment predictive value.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Surgical Oncology
volume
21
issue
9
pages
2911 - 2919
publisher
Springer
external identifiers
  • pmid:24777857
  • wos:000342143100017
  • scopus:84906261489
ISSN
1534-4681
DOI
10.1245/s10434-014-3708-4
language
English
LU publication?
yes
id
6729697b-757d-43ce-9363-1f5df1d8dd9c (old id 4429338)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24777857?dopt=Abstract
date added to LUP
2014-05-02 23:06:29
date last changed
2017-09-03 03:27:35
@article{6729697b-757d-43ce-9363-1f5df1d8dd9c,
  abstract     = {Patients with ductal carcinoma-in-situ (DCIS) are currently not prescribed adjuvant systemic treatment after surgery and radiotherapy. Prediction of DCIS patients who would benefit from radiotherapy is warranted. Statins have been suggested to exert radio-sensitizing effects. The target for cholesterol-lowering statins is HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathway. The aim of this study was to examine HMGCR expression in DCIS and study its treatment predictive value.},
  author       = {Butt, Salma and Butt, Talha and Jirström, Karin and Werner Hartman, Linda and Amini, Rose-Marie and Zhou, Wenjing and Wärnberg, Fredrik and Borgquist, Signe},
  issn         = {1534-4681},
  language     = {eng},
  number       = {9},
  pages        = {2911--2919},
  publisher    = {Springer},
  series       = {Annals of Surgical Oncology},
  title        = {The Target for Statins, HMG-CoA Reductase, Is Expressed in Ductal Carcinoma-In Situ and May Predict Patient Response to Radiotherapy.},
  url          = {http://dx.doi.org/10.1245/s10434-014-3708-4},
  volume       = {21},
  year         = {2014},
}