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Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes.

Yang, J ; Lernmark, Åke LU orcid ; Uusitalo, U M ; Lynch, K F ; Veijola, R ; Winkler, C ; Larsson, Helena LU orcid ; Rewers, M ; She, J-X and Ziegler, A G , et al. (2014) In International Journal of Obesity 38(12). p.1491-1496
Abstract
Objectives:Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.Methods:Repeated measures of weight and height were collected from 5969 children 2-4 years of age enrolled in The Environmental Determinants of Diabetes in the Young prospective study. Overweight and obesity was determined by the International Obesity Task Force cutoff values that correspond to body mass index (BMI) of 25 and 30 kg m(-)(2) at age... (More)
Objectives:Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.Methods:Repeated measures of weight and height were collected from 5969 children 2-4 years of age enrolled in The Environmental Determinants of Diabetes in the Young prospective study. Overweight and obesity was determined by the International Obesity Task Force cutoff values that correspond to body mass index (BMI) of 25 and 30 kg m(-)(2) at age 18.Results:The average BMI was comparable across specific HLA genotypes at every age point. The proportion of overweight was not different by HLA, but percent obesity varied by age with a decreasing trend among DQ2/8 carriers (P for trend=0.0315). A multivariable regression model suggested DQ2/2 was associated with higher obesity risk at age 4 (odds ratio, 2.41; 95% confidence interval, 1.21-4.80) after adjusting for the development of islet autoantibody and/or type 1 diabetes.Conclusions:The HLA-DQ2/2 genotype may predispose to obesity among 2-4-year-old children with genetic risk for type 1 diabetes.International Journal of Obesity advance online publication, 29 April 2014; doi:10.1038/ijo.2014.55. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Obesity
volume
38
issue
12
pages
1491 - 1496
publisher
Nature Publishing Group
external identifiers
  • pmid:24694666
  • wos:000347107400002
  • scopus:84927173834
  • pmid:24694666
ISSN
1476-5497
DOI
10.1038/ijo.2014.55
language
English
LU publication?
yes
id
f7f100da-9636-43ca-bd05-b89d5020d768 (old id 4431197)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24694666?dopt=Abstract
date added to LUP
2016-04-01 10:32:12
date last changed
2024-10-07 07:32:32
@article{f7f100da-9636-43ca-bd05-b89d5020d768,
  abstract     = {{Objectives:Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.Methods:Repeated measures of weight and height were collected from 5969 children 2-4 years of age enrolled in The Environmental Determinants of Diabetes in the Young prospective study. Overweight and obesity was determined by the International Obesity Task Force cutoff values that correspond to body mass index (BMI) of 25 and 30 kg m(-)(2) at age 18.Results:The average BMI was comparable across specific HLA genotypes at every age point. The proportion of overweight was not different by HLA, but percent obesity varied by age with a decreasing trend among DQ2/8 carriers (P for trend=0.0315). A multivariable regression model suggested DQ2/2 was associated with higher obesity risk at age 4 (odds ratio, 2.41; 95% confidence interval, 1.21-4.80) after adjusting for the development of islet autoantibody and/or type 1 diabetes.Conclusions:The HLA-DQ2/2 genotype may predispose to obesity among 2-4-year-old children with genetic risk for type 1 diabetes.International Journal of Obesity advance online publication, 29 April 2014; doi:10.1038/ijo.2014.55.}},
  author       = {{Yang, J and Lernmark, Åke and Uusitalo, U M and Lynch, K F and Veijola, R and Winkler, C and Larsson, Helena and Rewers, M and She, J-X and Ziegler, A G and Simell, O G and Hagopian, W A and Akolkar, B and Krischer, J P and Vehik, K}},
  issn         = {{1476-5497}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1491--1496}},
  publisher    = {{Nature Publishing Group}},
  series       = {{International Journal of Obesity}},
  title        = {{Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes.}},
  url          = {{https://lup.lub.lu.se/search/files/1926302/4882787.pdf}},
  doi          = {{10.1038/ijo.2014.55}},
  volume       = {{38}},
  year         = {{2014}},
}