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Absence of ongoing activity in fibres arising from proximal nerve ends regenerating into mesothelial chambers

Danielsen, N LU ; Shyu, B C; Dahlin, L B LU ; Lundborg, G LU and Andersson, S A LU (1986) In Pain 26(1). p.93-104
Abstract

Morphological studies have indicated that proximal nerve ends of transected rat sciatic nerves regenerating into preformed mesothelial chambers show a different organization as compared to neuromas developed in contact with a muscle fascia. We have studied the physiological properties of nerve fibres arising from these types of preparations with reference to ongoing activity, response to mechanical stimulation and noradrenaline sensitivity. The study included also fibres arising from ligated and encapsulated neuromas. Fibres with ongoing activity arising from the neuroma could be found from neuromas in contact with a muscle fascia and also from ligated and encapsulated neuromas. This ongoing activity was enhanced by mechanical... (More)

Morphological studies have indicated that proximal nerve ends of transected rat sciatic nerves regenerating into preformed mesothelial chambers show a different organization as compared to neuromas developed in contact with a muscle fascia. We have studied the physiological properties of nerve fibres arising from these types of preparations with reference to ongoing activity, response to mechanical stimulation and noradrenaline sensitivity. The study included also fibres arising from ligated and encapsulated neuromas. Fibres with ongoing activity arising from the neuroma could be found from neuromas in contact with a muscle fascia and also from ligated and encapsulated neuromas. This ongoing activity was enhanced by mechanical stimulation and i.v. infusion of noradrenaline. In contrast, fibres arising from proximal nerve ends in mesothelial chambers did not show ongoing activity. These silent fibres responded dynamically to light mechanical stimulation. Noradrenaline did not induce ongoing activity in these fibres.

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publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Disease Models, Animal, Electric Stimulation, Female, Nerve Endings, Nerve Fibers, Nerve Regeneration, Physical Stimulation, Rats, Rats, Inbred Strains, Sciatic Nerve, Self Mutilation, Spinal Nerve Roots, Stimulation, Chemical, Journal Article, Research Support, Non-U.S. Gov't
in
Pain
volume
26
issue
1
pages
93 - 104
publisher
Elsevier
external identifiers
  • scopus:0022655161
ISSN
0304-3959
DOI
10.1016/0304-3959(86)90176-4
language
English
LU publication?
no
id
4477e989-3df0-484c-aa57-2238f1cfd326
date added to LUP
2017-10-13 14:08:46
date last changed
2017-10-16 10:56:20
@article{4477e989-3df0-484c-aa57-2238f1cfd326,
  abstract     = {<p>Morphological studies have indicated that proximal nerve ends of transected rat sciatic nerves regenerating into preformed mesothelial chambers show a different organization as compared to neuromas developed in contact with a muscle fascia. We have studied the physiological properties of nerve fibres arising from these types of preparations with reference to ongoing activity, response to mechanical stimulation and noradrenaline sensitivity. The study included also fibres arising from ligated and encapsulated neuromas. Fibres with ongoing activity arising from the neuroma could be found from neuromas in contact with a muscle fascia and also from ligated and encapsulated neuromas. This ongoing activity was enhanced by mechanical stimulation and i.v. infusion of noradrenaline. In contrast, fibres arising from proximal nerve ends in mesothelial chambers did not show ongoing activity. These silent fibres responded dynamically to light mechanical stimulation. Noradrenaline did not induce ongoing activity in these fibres.</p>},
  author       = {Danielsen, N and Shyu, B C and Dahlin, L B and Lundborg, G and Andersson, S A},
  issn         = {0304-3959},
  keyword      = {Animals,Disease Models, Animal,Electric Stimulation,Female,Nerve Endings,Nerve Fibers,Nerve Regeneration,Physical Stimulation,Rats,Rats, Inbred Strains,Sciatic Nerve,Self Mutilation,Spinal Nerve Roots,Stimulation, Chemical,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {1},
  pages        = {93--104},
  publisher    = {Elsevier},
  series       = {Pain},
  title        = {Absence of ongoing activity in fibres arising from proximal nerve ends regenerating into mesothelial chambers},
  url          = {http://dx.doi.org/10.1016/0304-3959(86)90176-4},
  volume       = {26},
  year         = {1986},
}