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A new vessel segmentation algorithm for robust blood flow quantification from two-dimensional phase-contrast magnetic resonance images

Bidhult, Sebastian LU ; Hedström, Erik LU ; Carlsson, Marcus LU ; Töger, Johannes LU ; Steding-Ehrenborg, Katarina LU ; Arheden, Håkan LU ; Aletras, Anthony H LU and Heiberg, Einar LU (2019) In Clinical Physiology and Functional Imaging
Abstract

Blood flow measurements in the ascending aorta and pulmonary artery from phase-contrast magnetic resonance images require accurate time-resolved vessel segmentation over the cardiac cycle. Current semi-automatic segmentation methods often involve time consuming manual correction, relying on user experience for accurate results. The purpose of this study was to develop a semi-automatic vessel segmentation algorithm with shape constraints based on manual vessel delineations for robust segmentation of the ascending aorta and pulmonary artery, to evaluate the proposed method in healthy volunteers and patients with heart failure and congenital heart disease, to validate the method in a pulsatile flow phantom experiment, and to make the... (More)

Blood flow measurements in the ascending aorta and pulmonary artery from phase-contrast magnetic resonance images require accurate time-resolved vessel segmentation over the cardiac cycle. Current semi-automatic segmentation methods often involve time consuming manual correction, relying on user experience for accurate results. The purpose of this study was to develop a semi-automatic vessel segmentation algorithm with shape constraints based on manual vessel delineations for robust segmentation of the ascending aorta and pulmonary artery, to evaluate the proposed method in healthy volunteers and patients with heart failure and congenital heart disease, to validate the method in a pulsatile flow phantom experiment, and to make the method freely available for research purposes. Algorithm shape constraints were extracted from manual reference delineations of the ascending aorta (n=20) and pulmonary artery (n=20) and were included into a semi-automatic segmentation method only requiring manual delineation in one image. Bias and variability (bias±SD) for flow volume of the proposed algorithm versus manual reference delineations were 0·0±1·9ml in the ascending aorta (n=151; 7 healthy volunteers; 144 heart failure patients) and -1·7±2·9 ml in the pulmonary artery (n=40; 25 healthy volunteers; 15 patients with atrial septal defect). Inter-observer bias and variability were lower (p=0·008) for the proposed semi-automatic method (-0·1±0·9ml) compared to manual reference delineations (1·5±5·1ml). Phantom validation showed good agreement between the proposed method and timer-and-beaker flow volumes (0·4±2·7ml). In conclusion, the proposed semi-automatic vessel segmentation algorithm can be used for efficient analysis of flow and shunt volumes in the aorta and pulmonary artery. This article is protected by copyright. All rights reserved.

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organization
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Contribution to journal
publication status
epub
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Clinical Physiology and Functional Imaging
publisher
Wiley Online Library
external identifiers
  • scopus:85067391310
ISSN
1475-0961
DOI
10.1111/cpf.12582
language
English
LU publication?
yes
id
44bd94be-0349-449b-ad86-8893c28d45b0
date added to LUP
2019-05-26 16:09:47
date last changed
2019-07-30 05:02:22
@article{44bd94be-0349-449b-ad86-8893c28d45b0,
  abstract     = {<p>Blood flow measurements in the ascending aorta and pulmonary artery from phase-contrast magnetic resonance images require accurate time-resolved vessel segmentation over the cardiac cycle. Current semi-automatic segmentation methods often involve time consuming manual correction, relying on user experience for accurate results. The purpose of this study was to develop a semi-automatic vessel segmentation algorithm with shape constraints based on manual vessel delineations for robust segmentation of the ascending aorta and pulmonary artery, to evaluate the proposed method in healthy volunteers and patients with heart failure and congenital heart disease, to validate the method in a pulsatile flow phantom experiment, and to make the method freely available for research purposes. Algorithm shape constraints were extracted from manual reference delineations of the ascending aorta (n=20) and pulmonary artery (n=20) and were included into a semi-automatic segmentation method only requiring manual delineation in one image. Bias and variability (bias±SD) for flow volume of the proposed algorithm versus manual reference delineations were 0·0±1·9ml in the ascending aorta (n=151; 7 healthy volunteers; 144 heart failure patients) and -1·7±2·9 ml in the pulmonary artery (n=40; 25 healthy volunteers; 15 patients with atrial septal defect). Inter-observer bias and variability were lower (p=0·008) for the proposed semi-automatic method (-0·1±0·9ml) compared to manual reference delineations (1·5±5·1ml). Phantom validation showed good agreement between the proposed method and timer-and-beaker flow volumes (0·4±2·7ml). In conclusion, the proposed semi-automatic vessel segmentation algorithm can be used for efficient analysis of flow and shunt volumes in the aorta and pulmonary artery. This article is protected by copyright. All rights reserved.</p>},
  author       = {Bidhult, Sebastian and Hedström, Erik and Carlsson, Marcus and Töger, Johannes and Steding-Ehrenborg, Katarina and Arheden, Håkan and Aletras, Anthony H and Heiberg, Einar},
  issn         = {1475-0961},
  language     = {eng},
  month        = {05},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {A new vessel segmentation algorithm for robust blood flow quantification from two-dimensional phase-contrast magnetic resonance images},
  url          = {http://dx.doi.org/10.1111/cpf.12582},
  year         = {2019},
}