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Psychological Resilience and Quality of Life in Mycosis Fungoides Patients : A BIO-MUSE Study

Johansson, Angelica LU orcid ; Velickovic, Katarina LU ; Belfrage, Emma LU ; Drott, Kristina LU ; Johnsson, Per LU and Ek, Sara LU orcid (2026) In Acta Dermato-Venereologica 106.
Abstract

Cutaneous T-cell lymphoma is a chronic disease with a highly heterogeneous and unpre-dictable clinical course, and the impact on psychological resilience is still unknown. The primary aim was to investigate psychological resilience in cutaneous T-cell lymphoma patients over time and to relate it to dermatology-related quality of life (QoL) metrics. Psychological investigations were evaluated in 45 patients with mycosis fungoides included in the BIO-MUSE study. Psychological resilience was assessed using the Connor–Davidson Resilience Scale (CD-RISC), and dermatology-associated QoL was assessed with the Dermatology Life Quality Index (DLQI) and numeric rating scales for itch and sleep disorders. The resilience of the mycosis fungoides... (More)

Cutaneous T-cell lymphoma is a chronic disease with a highly heterogeneous and unpre-dictable clinical course, and the impact on psychological resilience is still unknown. The primary aim was to investigate psychological resilience in cutaneous T-cell lymphoma patients over time and to relate it to dermatology-related quality of life (QoL) metrics. Psychological investigations were evaluated in 45 patients with mycosis fungoides included in the BIO-MUSE study. Psychological resilience was assessed using the Connor–Davidson Resilience Scale (CD-RISC), and dermatology-associated QoL was assessed with the Dermatology Life Quality Index (DLQI) and numeric rating scales for itch and sleep disorders. The resilience of the mycosis fungoides patients was further compared to a Swedish general population cohort comprising more than 2,500 individuals. This study demonstrates that mycosis fungoides patients in the BIO-MUSE cohort, where 39 of 45 cases had early-stage disease, exhibit a high and stable resilience over 1 year of the disease. The CD-RISC score is higher than in a Swedish general population cohort and in a subgroup of that cohort with psoriasis or eczema. Furthermore, the DLQI was consistently low, indicating a higher QoL in the BIO-MUSE cohort than in published data for similar patient populations.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cutaneous T cell Lymphoma, dermatology, mycosis fungoides, psychological resilience, quality of life
in
Acta Dermato-Venereologica
volume
106
article number
adv-2025-0211
publisher
Medical Journals Limited
external identifiers
  • scopus:105043121660
  • pmid:42366576
ISSN
0001-5555
DOI
10.2340/actadv.v106.adv-2025-0211
language
English
LU publication?
yes
additional info
Publisher Copyright: © The Authors 2026.
id
44e21faa-6c72-4a12-93c8-e83755caf183
date added to LUP
2026-07-13 09:33:46
date last changed
2026-07-27 11:19:08
@article{44e21faa-6c72-4a12-93c8-e83755caf183,
  abstract     = {{<p>Cutaneous T-cell lymphoma is a chronic disease with a highly heterogeneous and unpre-dictable clinical course, and the impact on psychological resilience is still unknown. The primary aim was to investigate psychological resilience in cutaneous T-cell lymphoma patients over time and to relate it to dermatology-related quality of life (QoL) metrics. Psychological investigations were evaluated in 45 patients with mycosis fungoides included in the BIO-MUSE study. Psychological resilience was assessed using the Connor–Davidson Resilience Scale (CD-RISC), and dermatology-associated QoL was assessed with the Dermatology Life Quality Index (DLQI) and numeric rating scales for itch and sleep disorders. The resilience of the mycosis fungoides patients was further compared to a Swedish general population cohort comprising more than 2,500 individuals. This study demonstrates that mycosis fungoides patients in the BIO-MUSE cohort, where 39 of 45 cases had early-stage disease, exhibit a high and stable resilience over 1 year of the disease. The CD-RISC score is higher than in a Swedish general population cohort and in a subgroup of that cohort with psoriasis or eczema. Furthermore, the DLQI was consistently low, indicating a higher QoL in the BIO-MUSE cohort than in published data for similar patient populations.</p>}},
  author       = {{Johansson, Angelica and Velickovic, Katarina and Belfrage, Emma and Drott, Kristina and Johnsson, Per and Ek, Sara}},
  issn         = {{0001-5555}},
  keywords     = {{cutaneous T cell Lymphoma; dermatology; mycosis fungoides; psychological resilience; quality of life}},
  language     = {{eng}},
  publisher    = {{Medical Journals Limited}},
  series       = {{Acta Dermato-Venereologica}},
  title        = {{Psychological Resilience and Quality of Life in Mycosis Fungoides Patients : A BIO-MUSE Study}},
  url          = {{http://dx.doi.org/10.2340/actadv.v106.adv-2025-0211}},
  doi          = {{10.2340/actadv.v106.adv-2025-0211}},
  volume       = {{106}},
  year         = {{2026}},
}