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No independent association between pulse wave velocity and dementia : a population-based, prospective study

Nilsson, Erik D. LU ; Elmståhl, Sölve LU ; Minthon, Lennart LU ; Pihlsgård, Mats LU ; Nilsson, Peter M. LU ; Hansson, Oskar LU and Nägga, Katarina LU (2017) In Journal of Hypertension
Abstract

OBJECTIVE:: Carotid–femoral pulse wave velocity (CFPWV), a marker of aortic stiffness, has been associated with cognitive test results and markers of cerebral small vessel disease, but its association with dementia has not been studied in detail. Our aim was to assess the association of CFPWV with prevalent and incident dementia in a large population-based study. METHODS:: In total, CFPWV was measured in 3056 participants of the Malmö Diet and Cancer study 2007–2012 (age range 61–85 years). Individuals scoring below preset cut-offs on cognitive screening tests were thoroughly evaluated for prevalent dementia. Also, dementia diagnoses were retrieved from the Swedish National Patient Register up until 31 December 2014, and then validated... (More)

OBJECTIVE:: Carotid–femoral pulse wave velocity (CFPWV), a marker of aortic stiffness, has been associated with cognitive test results and markers of cerebral small vessel disease, but its association with dementia has not been studied in detail. Our aim was to assess the association of CFPWV with prevalent and incident dementia in a large population-based study. METHODS:: In total, CFPWV was measured in 3056 participants of the Malmö Diet and Cancer study 2007–2012 (age range 61–85 years). Individuals scoring below preset cut-offs on cognitive screening tests were thoroughly evaluated for prevalent dementia. Also, dementia diagnoses were retrieved from the Swedish National Patient Register up until 31 December 2014, and then validated through medical records and neuroimaging findings. RESULTS:: We identified 159 cases of dementia, of which 57 were classified as prevalent, and 102 as incident during a median follow-up of 4.6 years. In fully adjusted logistic regressions, CFPWV was not associated with prevalent all-cause dementia (odds ratio 0.95 per 1?m/s increase in CFPWV, 95% confidence interval 0.83–1.08), and it did not predict incident all-cause dementia (odds ratio 1.00, 95% confidence interval 0.91–1.09). Neither was CFPWV associated with subtypes of dementia (Alzheimerʼs disease, vascular dementia, mixed dementia), although the number of cases in subgroups were low. CONCLUSION:: No independent association was found between CFPWV and dementia. It remains a matter of debate why CFPWV repeatedly has been associated with cognitive test results and markers of cerebral small vessel disease, but not with dementia.

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author
organization
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Contribution to journal
publication status
epub
subject
in
Journal of Hypertension
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85023745678
ISSN
0263-6352
DOI
10.1097/HJH.0000000000001480
language
English
LU publication?
yes
id
45137c2e-6068-4416-8f89-8bb6f99f78e2
date added to LUP
2017-08-02 14:50:13
date last changed
2017-08-03 03:00:09
@article{45137c2e-6068-4416-8f89-8bb6f99f78e2,
  abstract     = {<p>OBJECTIVE:: Carotid–femoral pulse wave velocity (CFPWV), a marker of aortic stiffness, has been associated with cognitive test results and markers of cerebral small vessel disease, but its association with dementia has not been studied in detail. Our aim was to assess the association of CFPWV with prevalent and incident dementia in a large population-based study. METHODS:: In total, CFPWV was measured in 3056 participants of the Malmö Diet and Cancer study 2007–2012 (age range 61–85 years). Individuals scoring below preset cut-offs on cognitive screening tests were thoroughly evaluated for prevalent dementia. Also, dementia diagnoses were retrieved from the Swedish National Patient Register up until 31 December 2014, and then validated through medical records and neuroimaging findings. RESULTS:: We identified 159 cases of dementia, of which 57 were classified as prevalent, and 102 as incident during a median follow-up of 4.6 years. In fully adjusted logistic regressions, CFPWV was not associated with prevalent all-cause dementia (odds ratio 0.95 per 1?m/s increase in CFPWV, 95% confidence interval 0.83–1.08), and it did not predict incident all-cause dementia (odds ratio 1.00, 95% confidence interval 0.91–1.09). Neither was CFPWV associated with subtypes of dementia (Alzheimerʼs disease, vascular dementia, mixed dementia), although the number of cases in subgroups were low. CONCLUSION:: No independent association was found between CFPWV and dementia. It remains a matter of debate why CFPWV repeatedly has been associated with cognitive test results and markers of cerebral small vessel disease, but not with dementia.</p>},
  author       = {Nilsson, Erik D. and Elmståhl, Sölve and Minthon, Lennart and Pihlsgård, Mats and Nilsson, Peter M. and Hansson, Oskar and Nägga, Katarina},
  issn         = {0263-6352},
  language     = {eng},
  month        = {07},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {No independent association between pulse wave velocity and dementia : a population-based, prospective study},
  url          = {http://dx.doi.org/10.1097/HJH.0000000000001480},
  year         = {2017},
}