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Apolipoprotein E Genotype and the Diagnostic Accuracy of Cerebrospinal Fluid Biomarkers for Alzheimer Disease.

Lautner, Ronald; Palmqvist, Sebastian LU ; Mattsson, Niklas; Andreasson, Ulf; Wallin, Anders; Pålsson, Erik; Jakobsson, Joel; Herukka, Sanna-Kaisa; Owenius, Rikard and Olsson, Bob, et al. (2014) In JAMA Psychiatry 71(10). p.1183-1191
Abstract
Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to the association of the APOE ε4 allele with cortical Aβ deposition or whether APOE ε4 directly influences CSF levels of Aβ42 independently of Aβ pathology remains unknown.
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type
Contribution to journal
publication status
published
subject
in
JAMA Psychiatry
volume
71
issue
10
pages
1183 - 1191
publisher
American Medical Association
external identifiers
  • pmid:25162367
  • wos:000342900200013
  • scopus:84907805707
ISSN
2168-6238
DOI
10.1001/jamapsychiatry.2014.1060
language
English
LU publication?
yes
id
eb4a85e8-1f5b-4faf-8515-e37adfd34fc7 (old id 4613785)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25162367?dopt=Abstract
date added to LUP
2014-09-09 19:03:01
date last changed
2017-11-05 03:10:17
@article{eb4a85e8-1f5b-4faf-8515-e37adfd34fc7,
  abstract     = {Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to the association of the APOE ε4 allele with cortical Aβ deposition or whether APOE ε4 directly influences CSF levels of Aβ42 independently of Aβ pathology remains unknown.},
  author       = {Lautner, Ronald and Palmqvist, Sebastian and Mattsson, Niklas and Andreasson, Ulf and Wallin, Anders and Pålsson, Erik and Jakobsson, Joel and Herukka, Sanna-Kaisa and Owenius, Rikard and Olsson, Bob and Hampel, Harald and Rujescu, Dan and Ewers, Michael and Landén, Mikael and Minthon, Lennart and Blennow, Kaj and Zetterberg, Henrik and Hansson, Oskar},
  issn         = {2168-6238},
  language     = {eng},
  number       = {10},
  pages        = {1183--1191},
  publisher    = {American Medical Association},
  series       = {JAMA Psychiatry},
  title        = {Apolipoprotein E Genotype and the Diagnostic Accuracy of Cerebrospinal Fluid Biomarkers for Alzheimer Disease.},
  url          = {http://dx.doi.org/10.1001/jamapsychiatry.2014.1060},
  volume       = {71},
  year         = {2014},
}