Advanced

Changes of activity and isoforms of alkaline sphingomyelinase (nucleotide pyrophosphatase phosphodiesterase 7) in bile from patients undergoing endoscopic retrograde cholangiopancreatography.

Duan, Rui-Dong LU ; Hindorf, Ulf LU ; Cheng, Yajun LU ; Bergenzaun, Per LU ; Hall, Mats LU ; Hertervig, Erik LU and Nilsson, Åke LU (2014) In BMC Gastroenterology 14(1).
Abstract
Alkaline sphingomyelinase (NPP7) is an ecto-enzyme expressed in intestinal mucosa, which hydrolyses sphingomyelin (SM) to ceramide and inactivates platelet activating factor. It is also expressed in human liver and released in the bile. The enzyme may have anti-tumour and anti-inflammatory effects in colon and its levels are decreased in patients with colon cancer and ulcerative colitis. Active NPP7 is translated from a transcript of 1.4 kb, whereas an inactive form from a 1.2 kb mRNA was found in colon and liver cancer cell lines. While the roles of NPP7 in colon cancer have been intensively studied, less is known about the function and implications of NPP7 in the bile. The present study examines the changes of NPP7 in bile of patients... (More)
Alkaline sphingomyelinase (NPP7) is an ecto-enzyme expressed in intestinal mucosa, which hydrolyses sphingomyelin (SM) to ceramide and inactivates platelet activating factor. It is also expressed in human liver and released in the bile. The enzyme may have anti-tumour and anti-inflammatory effects in colon and its levels are decreased in patients with colon cancer and ulcerative colitis. Active NPP7 is translated from a transcript of 1.4 kb, whereas an inactive form from a 1.2 kb mRNA was found in colon and liver cancer cell lines. While the roles of NPP7 in colon cancer have been intensively studied, less is known about the function and implications of NPP7 in the bile. The present study examines the changes of NPP7 in bile of patients with various hepatobiliary diseases. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Gastroenterology
volume
14
issue
1
publisher
BMC Biomedical Centre, Lund University
external identifiers
  • pmid:25100243
  • wos:000340632700002
  • scopus:84906837288
ISSN
1471-230X
DOI
10.1186/1471-230X-14-138
language
English
LU publication?
yes
id
69588fae-f49a-411e-858a-b6a48bc39007 (old id 4615475)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25100243?dopt=Abstract
date added to LUP
2014-09-04 17:47:47
date last changed
2017-01-01 05:46:09
@article{69588fae-f49a-411e-858a-b6a48bc39007,
  abstract     = {Alkaline sphingomyelinase (NPP7) is an ecto-enzyme expressed in intestinal mucosa, which hydrolyses sphingomyelin (SM) to ceramide and inactivates platelet activating factor. It is also expressed in human liver and released in the bile. The enzyme may have anti-tumour and anti-inflammatory effects in colon and its levels are decreased in patients with colon cancer and ulcerative colitis. Active NPP7 is translated from a transcript of 1.4 kb, whereas an inactive form from a 1.2 kb mRNA was found in colon and liver cancer cell lines. While the roles of NPP7 in colon cancer have been intensively studied, less is known about the function and implications of NPP7 in the bile. The present study examines the changes of NPP7 in bile of patients with various hepatobiliary diseases.},
  articleno    = {138},
  author       = {Duan, Rui-Dong and Hindorf, Ulf and Cheng, Yajun and Bergenzaun, Per and Hall, Mats and Hertervig, Erik and Nilsson, Åke},
  issn         = {1471-230X},
  language     = {eng},
  number       = {1},
  publisher    = {BMC Biomedical Centre, Lund University},
  series       = {BMC Gastroenterology},
  title        = {Changes of activity and isoforms of alkaline sphingomyelinase (nucleotide pyrophosphatase phosphodiesterase 7) in bile from patients undergoing endoscopic retrograde cholangiopancreatography.},
  url          = {http://dx.doi.org/10.1186/1471-230X-14-138},
  volume       = {14},
  year         = {2014},
}