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Comparison of neuropsychological and brain imaging data in pediatric brain tumor patients surviving more than 10 years

Tonning Olsson, Ingrid LU ; Perrin, Sean LU ; Björkman-Burtscher, Isabella LU ; Lundgren, Johan LU ; Kahn, Anna LU and Johanson, Aki LU (2014) 16th International Symposium on Pediatric Neuro-Oncology In Neuro-Oncology 16(Suppl 1). p.99-104
Abstract
AIM: To explore the relationship between neuropsychological outcome and magnetic resonance imaging (MRI) findings in paediatric brain tumour patients surviving more than 10 years. BACKGROUND: Cognitive late sequelae after paediatric brain tumour have a multifactorial origin. Low age at diagnosis, cranial radiation therapy, intrathecal methotrexate treatment and increased intracranial pressure are known to predict cognitive sequelae. Cognitive sequelae have been related to MRI findings, but the relation between neuroimaging findings and neuropsychological impairment needs to be explored further. METHOD: Sixteen paediatric brain tumour survivors completed an extensive neuropsychological test battery and MRI 10 to 13 years after diagnosis.... (More)
AIM: To explore the relationship between neuropsychological outcome and magnetic resonance imaging (MRI) findings in paediatric brain tumour patients surviving more than 10 years. BACKGROUND: Cognitive late sequelae after paediatric brain tumour have a multifactorial origin. Low age at diagnosis, cranial radiation therapy, intrathecal methotrexate treatment and increased intracranial pressure are known to predict cognitive sequelae. Cognitive sequelae have been related to MRI findings, but the relation between neuroimaging findings and neuropsychological impairment needs to be explored further. METHOD: Sixteen paediatric brain tumour survivors completed an extensive neuropsychological test battery and MRI 10 to 13 years after diagnosis. Patients were first separately classified as positive or negative regarding neuropsychological impairment and MRI findings and then coded as congruent or incongruent, depending on whether neuropsychological outcome was in agreement with MRI also considering clinical data such as type and location of the brain tumour, post-operative status, treatments or premorbidity. RESULTS: Ten patients were classified as either positive or negative for both MRI and cognitive impairment if blinded for the second parameter and clinical data, and were also congruent for these two parameters when not blinded for clinical data and the second parameter. In five out of six initially incongruent patients the neuropsychological profile was in accordance with MRI findings when evaluating all data with the multidisciplinary holistic approach. CONCLUSIONS: Cognitive outcome in survivors of paediatric brain tumours depends on many different detrimental processes and shows high individual variation. Congruity between neuropsychological impairment and MRI findings might at first seem low. However, in the perspective of a clinical holistic evaluation of MRI findings and neuropsychological outcome considering the knowledge of clinical data such as type and location of the brain tumour, type of MRI findings (atrophy, gliosis, post-operative lesion), undergone treatments and radiation field as well as premorbid cognitive impairment congruity increases. (Less)
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organization
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Contribution to journal
publication status
published
subject
in
Neuro-Oncology
volume
16
issue
Suppl 1
pages
99 - 104
publisher
Oxford University Press
conference name
16th International Symposium on Pediatric Neuro-Oncology
external identifiers
  • other:doi:10.1093/neuonc/nou076
ISSN
1523-5866
DOI
10.1093/neuonc/nou076
language
English
LU publication?
yes
id
e403f7a6-4949-4cac-aa3d-bba7fbe4476f (old id 4627992)
date added to LUP
2014-09-08 14:45:26
date last changed
2016-06-29 08:46:20
@article{e403f7a6-4949-4cac-aa3d-bba7fbe4476f,
  abstract     = {AIM: To explore the relationship between neuropsychological outcome and magnetic resonance imaging (MRI) findings in paediatric brain tumour patients surviving more than 10 years. BACKGROUND: Cognitive late sequelae after paediatric brain tumour have a multifactorial origin. Low age at diagnosis, cranial radiation therapy, intrathecal methotrexate treatment and increased intracranial pressure are known to predict cognitive sequelae. Cognitive sequelae have been related to MRI findings, but the relation between neuroimaging findings and neuropsychological impairment needs to be explored further. METHOD: Sixteen paediatric brain tumour survivors completed an extensive neuropsychological test battery and MRI 10 to 13 years after diagnosis. Patients were first separately classified as positive or negative regarding neuropsychological impairment and MRI findings and then coded as congruent or incongruent, depending on whether neuropsychological outcome was in agreement with MRI also considering clinical data such as type and location of the brain tumour, post-operative status, treatments or premorbidity. RESULTS: Ten patients were classified as either positive or negative for both MRI and cognitive impairment if blinded for the second parameter and clinical data, and were also congruent for these two parameters when not blinded for clinical data and the second parameter. In five out of six initially incongruent patients the neuropsychological profile was in accordance with MRI findings when evaluating all data with the multidisciplinary holistic approach. CONCLUSIONS: Cognitive outcome in survivors of paediatric brain tumours depends on many different detrimental processes and shows high individual variation. Congruity between neuropsychological impairment and MRI findings might at first seem low. However, in the perspective of a clinical holistic evaluation of MRI findings and neuropsychological outcome considering the knowledge of clinical data such as type and location of the brain tumour, type of MRI findings (atrophy, gliosis, post-operative lesion), undergone treatments and radiation field as well as premorbid cognitive impairment congruity increases.},
  author       = {Tonning Olsson, Ingrid and Perrin, Sean and Björkman-Burtscher, Isabella and Lundgren, Johan and Kahn, Anna and Johanson, Aki},
  issn         = {1523-5866},
  language     = {eng},
  number       = {Suppl 1},
  pages        = {99--104},
  publisher    = {Oxford University Press},
  series       = {Neuro-Oncology},
  title        = {Comparison of neuropsychological and brain imaging data in pediatric brain tumor patients surviving more than 10 years},
  url          = {http://dx.doi.org/10.1093/neuonc/nou076},
  volume       = {16},
  year         = {2014},
}