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Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations

Fedirko, Veronika; Romieu, Isabelle; Aleksandrova, Krasimira; Pischon, Tobias; Trichopoulos, Dimitrios; Peeters, Petra H.; Romaguera-Bosch, Dora; Bueno-de-Mesquita, H. B(as); Dahm, Christina C. and Overvad, Kim, et al. (2014) In International Journal of Cancer 135(8). p.1949-1960
Abstract
General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (FIRS) and corresponding 95% confidence intervals (as). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, prediagnostic BMI kg/m2 was... (More)
General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (FIRS) and corresponding 95% confidence intervals (as). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, prediagnostic BMI kg/m2 was associated with a high risk for CRC-specific (HR = 1.26, 95% CI = 1.04-1.52) and all-cause (HR = 1.32, 95% CI = 1.12-1.56) death relative to BMI <25 kg/m(2). Every 5 kg/m(2) increase in BMI was associated with a high risk for CRC-specific (HR = 1.10, 95% CI = 1.02-1.19) and all-cause death (HR = 1.12, 95% Cl = 1.05-1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC-specific (HR = 1.09, 95% Cl = 1.02-1.16) and allcause death (HR= 1.11, 95% CI= 1.05-1.18). Similar associations were observed for waist-to-hip and waist-to-height ratios. Height was not associated with CRC-specific or all-cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre-diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis. (Less)
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publication status
published
subject
keywords
obesity, abdominal obesity, body composition, colorectal neoplasms, survival
in
International Journal of Cancer
volume
135
issue
8
pages
1949 - 1960
publisher
John Wiley & Sons
external identifiers
  • wos:000340524100021
  • scopus:84905721284
ISSN
0020-7136
DOI
10.1002/ijc.28841
language
English
LU publication?
yes
id
6a98e916-da75-42b7-b13a-8b0a00e81c67 (old id 4656037)
date added to LUP
2014-09-24 13:17:29
date last changed
2017-11-12 03:17:35
@article{6a98e916-da75-42b7-b13a-8b0a00e81c67,
  abstract     = {General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (FIRS) and corresponding 95% confidence intervals (as). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, prediagnostic BMI kg/m2 was associated with a high risk for CRC-specific (HR = 1.26, 95% CI = 1.04-1.52) and all-cause (HR = 1.32, 95% CI = 1.12-1.56) death relative to BMI &lt;25 kg/m(2). Every 5 kg/m(2) increase in BMI was associated with a high risk for CRC-specific (HR = 1.10, 95% CI = 1.02-1.19) and all-cause death (HR = 1.12, 95% Cl = 1.05-1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC-specific (HR = 1.09, 95% Cl = 1.02-1.16) and allcause death (HR= 1.11, 95% CI= 1.05-1.18). Similar associations were observed for waist-to-hip and waist-to-height ratios. Height was not associated with CRC-specific or all-cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre-diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.},
  author       = {Fedirko, Veronika and Romieu, Isabelle and Aleksandrova, Krasimira and Pischon, Tobias and Trichopoulos, Dimitrios and Peeters, Petra H. and Romaguera-Bosch, Dora and Bueno-de-Mesquita, H. B(as) and Dahm, Christina C. and Overvad, Kim and Chirlaque, Maria-Dolores and Johansen, Christoffer and Bidstrup, Pernille E. and Dalton, Susanne O. and Gunter, Marc J. and Wark, Petra A. and Norat, Teresa and Halkjaer, Jytte and Tjonneland, Anne and Dik, Vincent K. and Siersema, Peter D. and Boutron-Ruault, Marie-Christine and Dossus, Laure and Bastide, Nadia and Kuehn, Tilman and Kaaks, Rudolf and Boeing, Heiner and Trichopoulou, Antonia and Klinaki, Eleni and Katsoulis, Michalis and Pala, Valeria and Panico, Salvatore and Tumino, Rosario and Palli, Domenico and Vineis, Paolo and Weiderpass, Elisabete and Skeie, Guri and Gonzalez, Carlos A. and Sanchez, Maria-Jose and Barricarte, Aurelio and Amiano, Pilar and Ramon Quiros, J. and Manjer, Jonas and Jirström, Karin and Ljuslinder, Ingrid and Palmqvist, Richard and Khaw, Kay-Tee and Wareham, Nick and Bradbury, Kathryn E. and Stepien, Magdalena and Duarte-Salles, Talita and Riboli, Elio and Jenab, Mazda},
  issn         = {0020-7136},
  keyword      = {obesity,abdominal obesity,body composition,colorectal neoplasms,survival},
  language     = {eng},
  number       = {8},
  pages        = {1949--1960},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations},
  url          = {http://dx.doi.org/10.1002/ijc.28841},
  volume       = {135},
  year         = {2014},
}