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Long-Term Cognitive Sequelae After Pediatric Brain Tumor Related to Medical Risk Factors, Age, and Sex

Tonning Olsson, Ingrid LU ; Perrin, Sean LU ; Lundgren, Johan LU ; Hjorth, Lars LU and Johanson, Aki LU (2014) In Pediatric Neurology 51(4). p.515-521
Abstract
BACKGROUND:

Young age at diagnosis and treatment with cranial radiation therapy are well studied risk factors for cognitive impairment in pediatric brain tumor survivors. Other risk factors are hydrocephalus, surgery complications, and treatment with intrathecal chemotherapy. Female gender vulnerability to cognitive sequelae after cancer treatment has been evident in some studies, but no earlier studies have related this to tumor size. The purpose of our study was to find factors correlated with lowered IQ in a nationally representative sample of pediatric brain tumor patients referred for neuropsychologic evaluation. METHODS: Sixty-nine pediatric brain tumor patients, diagnosed 1988-2005 and tested 1995-2006, were included in the... (More)
BACKGROUND:

Young age at diagnosis and treatment with cranial radiation therapy are well studied risk factors for cognitive impairment in pediatric brain tumor survivors. Other risk factors are hydrocephalus, surgery complications, and treatment with intrathecal chemotherapy. Female gender vulnerability to cognitive sequelae after cancer treatment has been evident in some studies, but no earlier studies have related this to tumor size. The purpose of our study was to find factors correlated with lowered IQ in a nationally representative sample of pediatric brain tumor patients referred for neuropsychologic evaluation. METHODS: Sixty-nine pediatric brain tumor patients, diagnosed 1988-2005 and tested 1995-2006, were included in the study. In a series of stepwise multiple regressions, the relationship of IQ to disease, treatment, and individual variables (sex and syndromes) were evaluated. A subanalysis was made of the covariation between sex and tumor size. RESULTS: The patients had generally suppressed IQ and impairments in executive function, memory, and attention. Lowered IQ was associated with young age at diagnosis, being male, tumor size, and treatment with whole-brain radiation therapy. A sex difference

was evident for patients with increased intracranial pressure at diagnosis with males having larger tumors. Tumor size was found to be a better predictor of cognitive sequelae than sex. CONCLUSIONS:

Whole-brain radiation therapy, large tumors, young age at diagnosis, and male gender are risk factors for late cognitive sequelae after pediatric brain tumors. When examining sex differences, tumor size at diagnosis needs to be taken into account. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pediatric brain tumor, cognition, sex, whole-brain radiation therapy
in
Pediatric Neurology
volume
51
issue
4
pages
515 - 521
publisher
Elsevier
external identifiers
  • pmid:25266614
  • wos:000343963600009
  • scopus:84908131137
ISSN
0887-8994
DOI
10.1016/j.pediatrneurol.2014.06.011
language
English
LU publication?
yes
id
becd4cc9-e455-4830-b868-bf7fcf367b0b (old id 4690634)
date added to LUP
2014-10-01 08:09:42
date last changed
2017-05-28 03:13:39
@article{becd4cc9-e455-4830-b868-bf7fcf367b0b,
  abstract     = {BACKGROUND:<br/><br>
Young age at diagnosis and treatment with cranial radiation therapy are well studied risk factors for cognitive impairment in pediatric brain tumor survivors. Other risk factors are hydrocephalus, surgery complications, and treatment with intrathecal chemotherapy. Female gender vulnerability to cognitive sequelae after cancer treatment has been evident in some studies, but no earlier studies have related this to tumor size. The purpose of our study was to find factors correlated with lowered IQ in a nationally representative sample of pediatric brain tumor patients referred for neuropsychologic evaluation. METHODS: Sixty-nine pediatric brain tumor patients, diagnosed 1988-2005 and tested 1995-2006, were included in the study. In a series of stepwise multiple regressions, the relationship of IQ to disease, treatment, and individual variables (sex and syndromes) were evaluated. A subanalysis was made of the covariation between sex and tumor size. RESULTS: The patients had generally suppressed IQ and impairments in executive function, memory, and attention. Lowered IQ was associated with young age at diagnosis, being male, tumor size, and treatment with whole-brain radiation therapy. A sex difference<br/><br>
was evident for patients with increased intracranial pressure at diagnosis with males having larger tumors. Tumor size was found to be a better predictor of cognitive sequelae than sex. CONCLUSIONS:<br/><br>
Whole-brain radiation therapy, large tumors, young age at diagnosis, and male gender are risk factors for late cognitive sequelae after pediatric brain tumors. When examining sex differences, tumor size at diagnosis needs to be taken into account.},
  author       = {Tonning Olsson, Ingrid and Perrin, Sean and Lundgren, Johan and Hjorth, Lars and Johanson, Aki},
  issn         = {0887-8994},
  keyword      = {pediatric brain tumor,cognition,sex,whole-brain radiation therapy},
  language     = {eng},
  number       = {4},
  pages        = {515--521},
  publisher    = {Elsevier},
  series       = {Pediatric Neurology},
  title        = {Long-Term Cognitive Sequelae After Pediatric Brain Tumor Related to Medical Risk Factors, Age, and Sex},
  url          = {http://dx.doi.org/10.1016/j.pediatrneurol.2014.06.011},
  volume       = {51},
  year         = {2014},
}