Advanced

Multimodal Detection of Iron Oxide Nanoparticles in Rat Lymph Nodes Using Magnetomotive Ultrasound Imaging and Magnetic Resonance Imaging

Evertsson, Maria LU ; Kjellman, Pontus LU ; Cinthio, Magnus LU ; Fredriksson, Sarah; in 't Zandt, René LU ; Persson, Hans W LU and Jansson, Tomas LU (2014) In IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 61(8). p.1276-1283
Abstract
Detection and removal of sentinel lymph nodes (SLN) is important in the diagnosis and treatment of cancer. The SLN is the first regional lymph node draining the primary tumor, and if the cancer has spread, it is most likely to find metastases in the SLN. In this study, we have for the first time been able to image the very same contrast agent, superparamagnetic iron oxide nanoparticles (SPIO-NPs), in rat SLNs by using both our frequency-and phase-gated magnetomotive ultrasound (MMUS) algorithm and conventional magnetic resonance imaging (MRI); MMUS post mortem, MRI in vivo. For both higher NP-concentration and smaller NPs, we found that the MMUS data showed a larger magnetomotive displacement (1.56 +/- 0.43 and 1.94 +/- 0.54 times larger,... (More)
Detection and removal of sentinel lymph nodes (SLN) is important in the diagnosis and treatment of cancer. The SLN is the first regional lymph node draining the primary tumor, and if the cancer has spread, it is most likely to find metastases in the SLN. In this study, we have for the first time been able to image the very same contrast agent, superparamagnetic iron oxide nanoparticles (SPIO-NPs), in rat SLNs by using both our frequency-and phase-gated magnetomotive ultrasound (MMUS) algorithm and conventional magnetic resonance imaging (MRI); MMUS post mortem, MRI in vivo. For both higher NP-concentration and smaller NPs, we found that the MMUS data showed a larger magnetomotive displacement (1.56 +/- 0.43 and 1.94 +/- 0.54 times larger, respectively) and that the MR-images were affected to a higher degree. The MMUS displacement also increased with lower excitation frequency (1.95 +/- 0.64 times larger for 5 Hz compared with 15 Hz) and higher excitation voltage (2.95 +/- 1.44 times larger for 30 V compared with 10 V). The results show that MMUS has potential to be used as bedside guidance during SLN surgery, imaging the same particles that were used in prior staging with other imaging techniques. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
volume
61
issue
8
pages
1276 - 1283
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • wos:000341591400004
  • scopus:84905262170
ISSN
0885-3010
DOI
10.1109/TUFFC.2014.3034
language
English
LU publication?
yes
id
a305df3c-42f6-4661-ac85-96a1a1a9d535 (old id 4716967)
date added to LUP
2014-11-06 13:03:56
date last changed
2017-11-16 13:00:50
@article{a305df3c-42f6-4661-ac85-96a1a1a9d535,
  abstract     = {Detection and removal of sentinel lymph nodes (SLN) is important in the diagnosis and treatment of cancer. The SLN is the first regional lymph node draining the primary tumor, and if the cancer has spread, it is most likely to find metastases in the SLN. In this study, we have for the first time been able to image the very same contrast agent, superparamagnetic iron oxide nanoparticles (SPIO-NPs), in rat SLNs by using both our frequency-and phase-gated magnetomotive ultrasound (MMUS) algorithm and conventional magnetic resonance imaging (MRI); MMUS post mortem, MRI in vivo. For both higher NP-concentration and smaller NPs, we found that the MMUS data showed a larger magnetomotive displacement (1.56 +/- 0.43 and 1.94 +/- 0.54 times larger, respectively) and that the MR-images were affected to a higher degree. The MMUS displacement also increased with lower excitation frequency (1.95 +/- 0.64 times larger for 5 Hz compared with 15 Hz) and higher excitation voltage (2.95 +/- 1.44 times larger for 30 V compared with 10 V). The results show that MMUS has potential to be used as bedside guidance during SLN surgery, imaging the same particles that were used in prior staging with other imaging techniques.},
  author       = {Evertsson, Maria and Kjellman, Pontus and Cinthio, Magnus and Fredriksson, Sarah and in 't Zandt, René and Persson, Hans W and Jansson, Tomas},
  issn         = {0885-3010},
  language     = {eng},
  number       = {8},
  pages        = {1276--1283},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  series       = {IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control},
  title        = {Multimodal Detection of Iron Oxide Nanoparticles in Rat Lymph Nodes Using Magnetomotive Ultrasound Imaging and Magnetic Resonance Imaging},
  url          = {http://dx.doi.org/10.1109/TUFFC.2014.3034},
  volume       = {61},
  year         = {2014},
}