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Advanced clinical MRI for better outcome in epilepsy surgery. Focusing on fMRI and prediction of verbal memory decline.

Strandberg, Maria LU (2014) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2014:132.
Abstract
Abstract

Aim: The aim of the thesis was to evaluate the use of advanced MRI technology to improve results of epilepsy surgery,

with focus on language and memory functions.

Methods: In paper I, 25 patients with drug-resistant epilepsy were retrospectively included in the study for having been

referred to high resolution 3T MRI with and without surface coils. The surface coils were placed over the suspected

epileptogenic zone. The efficacy of the coils was assessed and graded in relation to their placement. In papers II, III and

IV, a functional MRI (fMRI) paradigm, including both a verbal encoding task and a visuospatial task, was designed and

implemented. The medial temporal... (More)
Abstract

Aim: The aim of the thesis was to evaluate the use of advanced MRI technology to improve results of epilepsy surgery,

with focus on language and memory functions.

Methods: In paper I, 25 patients with drug-resistant epilepsy were retrospectively included in the study for having been

referred to high resolution 3T MRI with and without surface coils. The surface coils were placed over the suspected

epileptogenic zone. The efficacy of the coils was assessed and graded in relation to their placement. In papers II, III and

IV, a functional MRI (fMRI) paradigm, including both a verbal encoding task and a visuospatial task, was designed and

implemented. The medial temporal lobe (MTL) for memory and the anterior language area were studied. In paper III, a

standard word generation fMRI paradigm was also included. In these three studies, the test was performed in 15 healthy

right handed subjects (paper II), 6 patients with drug-resistant temporal lobe epilepsy (TLE) with mixed handedness and

10 controls (paper III) and 14 TLE patients eligible for resective surgery (paper IV), respectively. A bootstrap algorithm

was used to calculate lateralization indices (LI) and LI-curves. In paper IV, a clinical risk assessment score was created from

collected clinical data. Additional value from fMRI LI was correlated to post-surgical memory decline.

Results: Surface coil 3T MRI did not contribute to detection of previously undiagnosed lesions. In 20% of patients, 3T

MRI, compared with previous 1.0-1.5T MRI, provided new information about cortical lesions. The fMRI paradigm

visualized memory-related activity in the MTL and provided information regarding language processes. LI and LI-curves

for memory at group level were consistent with previous studies, but a variety of activation effects were found at the

individual level. LI-curves added complementary information for individual subjects with uncharacteristic results. The

verbal encoding task provided information on verbal memory, which had equal lateralization as language in right-handed

subjects, but not always in left-handed subjects and TLE patients. Bilateral fMRI language representation was seen in 2

right TLE patients who later suffered verbal memory decline post-operatively.

Conclusion: High resolution 3T MRI is valuable for lesion detection, but surface coils do not provide further crucial

information. The fMRI paradigm activates memory and language areas that can be studied at an individual level using LIcurves.

Analysis of language patterns seems to be important for prediction of memory outcome in both left and right TLE.

fMRI indices may identify an unexpected high risk for post-operative verbal memory decline in right TLE patients. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Professor of Neurology Duncan, John, MA, DM, FRCP, FMedSci, Professor of Neurology – UCL, U.K.
organization
publishing date
type
Thesis
publication status
published
subject
keywords
3T MRI, surface coils, epilepsy surgery, fMRI, TLE, lateralization index, MTL, verbal encoding
categories
Higher Education
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2014:132
pages
67 pages
publisher
Neurology, Lund
defense location
Segerfalksalen, Wallenberg neurocentrum, Sölvegatan 17, Lund
defense date
2014-11-29 10:30
ISSN
1652-8220
ISBN
978-91-7619-061-6
language
English
LU publication?
yes
id
106d37da-9a34-496c-83dc-cdfb11fc1daf (old id 4778682)
date added to LUP
2014-11-12 08:14:38
date last changed
2016-09-19 08:44:51
@phdthesis{106d37da-9a34-496c-83dc-cdfb11fc1daf,
  abstract     = {Abstract<br/><br>
Aim: The aim of the thesis was to evaluate the use of advanced MRI technology to improve results of epilepsy surgery,<br/><br>
with focus on language and memory functions.<br/><br>
Methods: In paper I, 25 patients with drug-resistant epilepsy were retrospectively included in the study for having been<br/><br>
referred to high resolution 3T MRI with and without surface coils. The surface coils were placed over the suspected<br/><br>
epileptogenic zone. The efficacy of the coils was assessed and graded in relation to their placement. In papers II, III and<br/><br>
IV, a functional MRI (fMRI) paradigm, including both a verbal encoding task and a visuospatial task, was designed and<br/><br>
implemented. The medial temporal lobe (MTL) for memory and the anterior language area were studied. In paper III, a<br/><br>
standard word generation fMRI paradigm was also included. In these three studies, the test was performed in 15 healthy<br/><br>
right handed subjects (paper II), 6 patients with drug-resistant temporal lobe epilepsy (TLE) with mixed handedness and<br/><br>
10 controls (paper III) and 14 TLE patients eligible for resective surgery (paper IV), respectively. A bootstrap algorithm<br/><br>
was used to calculate lateralization indices (LI) and LI-curves. In paper IV, a clinical risk assessment score was created from<br/><br>
collected clinical data. Additional value from fMRI LI was correlated to post-surgical memory decline.<br/><br>
Results: Surface coil 3T MRI did not contribute to detection of previously undiagnosed lesions. In 20% of patients, 3T<br/><br>
MRI, compared with previous 1.0-1.5T MRI, provided new information about cortical lesions. The fMRI paradigm<br/><br>
visualized memory-related activity in the MTL and provided information regarding language processes. LI and LI-curves<br/><br>
for memory at group level were consistent with previous studies, but a variety of activation effects were found at the<br/><br>
individual level. LI-curves added complementary information for individual subjects with uncharacteristic results. The<br/><br>
verbal encoding task provided information on verbal memory, which had equal lateralization as language in right-handed<br/><br>
subjects, but not always in left-handed subjects and TLE patients. Bilateral fMRI language representation was seen in 2<br/><br>
right TLE patients who later suffered verbal memory decline post-operatively.<br/><br>
Conclusion: High resolution 3T MRI is valuable for lesion detection, but surface coils do not provide further crucial<br/><br>
information. The fMRI paradigm activates memory and language areas that can be studied at an individual level using LIcurves.<br/><br>
Analysis of language patterns seems to be important for prediction of memory outcome in both left and right TLE.<br/><br>
fMRI indices may identify an unexpected high risk for post-operative verbal memory decline in right TLE patients.},
  author       = {Strandberg, Maria},
  isbn         = {978-91-7619-061-6},
  issn         = {1652-8220},
  keyword      = {3T MRI,surface coils,epilepsy surgery,fMRI,TLE,lateralization index,MTL,verbal encoding},
  language     = {eng},
  pages        = {67},
  publisher    = {Neurology, Lund},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series},
  title        = {Advanced clinical MRI for better outcome in epilepsy surgery. Focusing on fMRI and prediction of verbal memory decline.},
  volume       = {2014:132},
  year         = {2014},
}