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fMRI memory assessment in healthy subjects: a new approach to view lateralization data at an individual level.

Strandberg, Maria LU ; Elfgren, Christina LU ; Mannfolk, Peter LU ; Olsrud, Johan LU ; Stenberg, Lars LU ; van Westen, Danielle LU ; Larsson, Elna-Marie ; Rorsman, Ia LU and Källén, Kristina LU (2011) In Brain Imaging and Behavior 5. p.1-11
Abstract
We present a comprehensive and clinically applicable fMRI test-including both a verbal and a visuospatial task-for assessment of hemispheric specific memory in the medial temporal lobe (MTL). fMRI data was collected from 15 healthy right-handed volunteers. Whole-brain activation was analyzed as well as activation in two regions of interest: the MTL and the anterior speech area. Laterality indices (LI) and LI-curves were calculated using the LI toolbox of Wilke and Lidzba, 2007. The fMRI paradigms successfully visualized memory-related activity in the MTL, the verbal memory measure also provided information of language lateralization. Eleven subjects showed left lateralized verbal encoding in the MTL, visuospatial memory activation was... (More)
We present a comprehensive and clinically applicable fMRI test-including both a verbal and a visuospatial task-for assessment of hemispheric specific memory in the medial temporal lobe (MTL). fMRI data was collected from 15 healthy right-handed volunteers. Whole-brain activation was analyzed as well as activation in two regions of interest: the MTL and the anterior speech area. Laterality indices (LI) and LI-curves were calculated using the LI toolbox of Wilke and Lidzba, 2007. The fMRI paradigms successfully visualized memory-related activity in the MTL, the verbal memory measure also provided information of language lateralization. Eleven subjects showed left lateralized verbal encoding in the MTL, visuospatial memory activation was divided equally between left and right, and 14/15 subjects had left lateralized language. Lateralization data at the group level were consistent with previous studies, but a variety of activation effects were found at the individual level indicating differences in strategy during verbal and visuospatial processing. Further studies using the presented method are needed to determine its clinical usefulness. (Less)
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Contribution to journal
publication status
published
subject
in
Brain Imaging and Behavior
volume
5
pages
1 - 11
publisher
Springer
external identifiers
  • wos:000286464700001
  • pmid:20862617
  • scopus:78751676903
  • pmid:20862617
ISSN
1931-7557
DOI
10.1007/s11682-010-9106-z
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diagnostic Radiology, (Lund) (013038000), Radiation Physics, Lund (013034000), Department of Psychogeriatrics (013304000), Neurology, Lund (013027000)
id
c5ea378c-ee20-4434-8462-f29f10784b59 (old id 1687949)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20862617?dopt=Abstract
http://link.springer.com/article/10.1007%2Fs11682-010-9106-z
date added to LUP
2016-04-04 08:56:31
date last changed
2019-10-21 02:17:59
@article{c5ea378c-ee20-4434-8462-f29f10784b59,
  abstract     = {We present a comprehensive and clinically applicable fMRI test-including both a verbal and a visuospatial task-for assessment of hemispheric specific memory in the medial temporal lobe (MTL). fMRI data was collected from 15 healthy right-handed volunteers. Whole-brain activation was analyzed as well as activation in two regions of interest: the MTL and the anterior speech area. Laterality indices (LI) and LI-curves were calculated using the LI toolbox of Wilke and Lidzba, 2007. The fMRI paradigms successfully visualized memory-related activity in the MTL, the verbal memory measure also provided information of language lateralization. Eleven subjects showed left lateralized verbal encoding in the MTL, visuospatial memory activation was divided equally between left and right, and 14/15 subjects had left lateralized language. Lateralization data at the group level were consistent with previous studies, but a variety of activation effects were found at the individual level indicating differences in strategy during verbal and visuospatial processing. Further studies using the presented method are needed to determine its clinical usefulness.},
  author       = {Strandberg, Maria and Elfgren, Christina and Mannfolk, Peter and Olsrud, Johan and Stenberg, Lars and van Westen, Danielle and Larsson, Elna-Marie and Rorsman, Ia and Källén, Kristina},
  issn         = {1931-7557},
  language     = {eng},
  pages        = {1--11},
  publisher    = {Springer},
  series       = {Brain Imaging and Behavior},
  title        = {fMRI memory assessment in healthy subjects: a new approach to view lateralization data at an individual level.},
  url          = {http://dx.doi.org/10.1007/s11682-010-9106-z},
  doi          = {10.1007/s11682-010-9106-z},
  volume       = {5},
  year         = {2011},
}