fMRI memory assessment in healthy subjects: a new approach to view lateralization data at an individual level.
(2011) In Brain Imaging and Behavior 5. p.1-11- Abstract
- We present a comprehensive and clinically applicable fMRI test-including both a verbal and a visuospatial task-for assessment of hemispheric specific memory in the medial temporal lobe (MTL). fMRI data was collected from 15 healthy right-handed volunteers. Whole-brain activation was analyzed as well as activation in two regions of interest: the MTL and the anterior speech area. Laterality indices (LI) and LI-curves were calculated using the LI toolbox of Wilke and Lidzba, 2007. The fMRI paradigms successfully visualized memory-related activity in the MTL, the verbal memory measure also provided information of language lateralization. Eleven subjects showed left lateralized verbal encoding in the MTL, visuospatial memory activation was... (More)
- We present a comprehensive and clinically applicable fMRI test-including both a verbal and a visuospatial task-for assessment of hemispheric specific memory in the medial temporal lobe (MTL). fMRI data was collected from 15 healthy right-handed volunteers. Whole-brain activation was analyzed as well as activation in two regions of interest: the MTL and the anterior speech area. Laterality indices (LI) and LI-curves were calculated using the LI toolbox of Wilke and Lidzba, 2007. The fMRI paradigms successfully visualized memory-related activity in the MTL, the verbal memory measure also provided information of language lateralization. Eleven subjects showed left lateralized verbal encoding in the MTL, visuospatial memory activation was divided equally between left and right, and 14/15 subjects had left lateralized language. Lateralization data at the group level were consistent with previous studies, but a variety of activation effects were found at the individual level indicating differences in strategy during verbal and visuospatial processing. Further studies using the presented method are needed to determine its clinical usefulness. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1687949
- author
- Strandberg, Maria LU ; Elfgren, Christina LU ; Mannfolk, Peter LU ; Olsrud, Johan LU ; Stenberg, Lars LU ; van Westen, Danielle LU ; Larsson, Elna-Marie ; Rorsman, Ia LU and Källén, Kristina LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Brain Imaging and Behavior
- volume
- 5
- pages
- 1 - 11
- publisher
- Springer
- external identifiers
-
- wos:000286464700001
- pmid:20862617
- scopus:78751676903
- pmid:20862617
- ISSN
- 1931-7557
- DOI
- 10.1007/s11682-010-9106-z
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diagnostic Radiology, (Lund) (013038000), Radiation Physics, Lund (013034000), Department of Psychogeriatrics (013304000), Neurology, Lund (013027000)
- id
- c5ea378c-ee20-4434-8462-f29f10784b59 (old id 1687949)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20862617?dopt=Abstract
- http://link.springer.com/article/10.1007%2Fs11682-010-9106-z
- date added to LUP
- 2016-04-04 08:56:31
- date last changed
- 2022-02-20 22:50:14
@article{c5ea378c-ee20-4434-8462-f29f10784b59, abstract = {{We present a comprehensive and clinically applicable fMRI test-including both a verbal and a visuospatial task-for assessment of hemispheric specific memory in the medial temporal lobe (MTL). fMRI data was collected from 15 healthy right-handed volunteers. Whole-brain activation was analyzed as well as activation in two regions of interest: the MTL and the anterior speech area. Laterality indices (LI) and LI-curves were calculated using the LI toolbox of Wilke and Lidzba, 2007. The fMRI paradigms successfully visualized memory-related activity in the MTL, the verbal memory measure also provided information of language lateralization. Eleven subjects showed left lateralized verbal encoding in the MTL, visuospatial memory activation was divided equally between left and right, and 14/15 subjects had left lateralized language. Lateralization data at the group level were consistent with previous studies, but a variety of activation effects were found at the individual level indicating differences in strategy during verbal and visuospatial processing. Further studies using the presented method are needed to determine its clinical usefulness.}}, author = {{Strandberg, Maria and Elfgren, Christina and Mannfolk, Peter and Olsrud, Johan and Stenberg, Lars and van Westen, Danielle and Larsson, Elna-Marie and Rorsman, Ia and Källén, Kristina}}, issn = {{1931-7557}}, language = {{eng}}, pages = {{1--11}}, publisher = {{Springer}}, series = {{Brain Imaging and Behavior}}, title = {{fMRI memory assessment in healthy subjects: a new approach to view lateralization data at an individual level.}}, url = {{http://dx.doi.org/10.1007/s11682-010-9106-z}}, doi = {{10.1007/s11682-010-9106-z}}, volume = {{5}}, year = {{2011}}, }