Adherence to the EAT-Lancet diet, plasma proteomics and the risk of chronic obstructive pulmonary disease
(2025) In Thorax p.1-10- Abstract
BACKGROUND AND AIMS: Adhering to the EAT-Lancet diet has been observed to be associated with lower risks of various morbidities. This study aimed to investigate the association of adhering to the EAT-Lancet diet with incident chronic obstructive pulmonary disease (COPD) and identify plasma proteins mediating such association.
METHODS: This prospective study involved 202 340 participants free of COPD at baseline from the UK Biobank. Adherence to the EAT-Lancet diet was assessed by four different diet indices. Mediation effects of plasma proteins were investigated in a subcohort of 21 186 participants with information on plasma proteins measured by the OLINK Explore-3072 platform.
RESULTS: Compared with individuals with the... (More)
BACKGROUND AND AIMS: Adhering to the EAT-Lancet diet has been observed to be associated with lower risks of various morbidities. This study aimed to investigate the association of adhering to the EAT-Lancet diet with incident chronic obstructive pulmonary disease (COPD) and identify plasma proteins mediating such association.
METHODS: This prospective study involved 202 340 participants free of COPD at baseline from the UK Biobank. Adherence to the EAT-Lancet diet was assessed by four different diet indices. Mediation effects of plasma proteins were investigated in a subcohort of 21 186 participants with information on plasma proteins measured by the OLINK Explore-3072 platform.
RESULTS: Compared with individuals with the lowest adherence to the EAT-Lancet diet, those with higher adherence had a lower risk of developing COPD, and the HRs (95% CIs) for the highest adherence group versus the lowest were 0.607 (0.558 to 0.660) for the Willett EAT-Lancet index, 0.666 (0.593 to 0.748) for the Knuppel EAT-Lancet index, 0.586 (0.513 to 0.668) for the Stubbendorff EAT-Lancet index and 0.674 (0.620 to 0.732) for the Kesse-Guyot EAT-Lancet index. A total of 534, 149, 486 and 489 proteins showed significant mediation effects between the Willett, Knuppel, Stubbendorff or Kesse-Guyot EAT-Lancet index and incident COPD. The overall proteomic scores mediated 34.43% (95% CI: 22.86% to 53.45%), 24.15% (13.20% to 72.99%), 22.96% (14.53% to 41.13%) and 34.63% (21.26% to 60.38%) of the associations between the Willett, Knuppel, Stubbendorff or Kesse-Guyot EAT-Lancet index and incident COPD.
CONCLUSION: Higher adherence to the EAT-Lancet diet was associated with a lower risk of COPD, and a wide range of circulating plasma proteins mediated such association.
(Less)
- author
- Lu, Xujia ; Pei, Yalong ; Geng, Yang ; Fan, Yulong ; Lu, Xinmei ; Jiang, Lan ; Borné, Yan LU and Ke, Chaofu
- organization
- publishing date
- 2025-08-24
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Thorax
- pages
- 1 - 10
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:105014277260
- pmid:40850790
- ISSN
- 1468-3296
- DOI
- 10.1136/thorax-2025-223046
- language
- English
- LU publication?
- yes
- additional info
- © Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.
- id
- 479c4059-0ff4-4dd7-92a5-e5a56c52772e
- date added to LUP
- 2025-09-12 08:18:40
- date last changed
- 2025-10-25 08:31:59
@article{479c4059-0ff4-4dd7-92a5-e5a56c52772e,
abstract = {{<p>BACKGROUND AND AIMS: Adhering to the EAT-Lancet diet has been observed to be associated with lower risks of various morbidities. This study aimed to investigate the association of adhering to the EAT-Lancet diet with incident chronic obstructive pulmonary disease (COPD) and identify plasma proteins mediating such association.</p><p>METHODS: This prospective study involved 202 340 participants free of COPD at baseline from the UK Biobank. Adherence to the EAT-Lancet diet was assessed by four different diet indices. Mediation effects of plasma proteins were investigated in a subcohort of 21 186 participants with information on plasma proteins measured by the OLINK Explore-3072 platform.</p><p>RESULTS: Compared with individuals with the lowest adherence to the EAT-Lancet diet, those with higher adherence had a lower risk of developing COPD, and the HRs (95% CIs) for the highest adherence group versus the lowest were 0.607 (0.558 to 0.660) for the Willett EAT-Lancet index, 0.666 (0.593 to 0.748) for the Knuppel EAT-Lancet index, 0.586 (0.513 to 0.668) for the Stubbendorff EAT-Lancet index and 0.674 (0.620 to 0.732) for the Kesse-Guyot EAT-Lancet index. A total of 534, 149, 486 and 489 proteins showed significant mediation effects between the Willett, Knuppel, Stubbendorff or Kesse-Guyot EAT-Lancet index and incident COPD. The overall proteomic scores mediated 34.43% (95% CI: 22.86% to 53.45%), 24.15% (13.20% to 72.99%), 22.96% (14.53% to 41.13%) and 34.63% (21.26% to 60.38%) of the associations between the Willett, Knuppel, Stubbendorff or Kesse-Guyot EAT-Lancet index and incident COPD.</p><p>CONCLUSION: Higher adherence to the EAT-Lancet diet was associated with a lower risk of COPD, and a wide range of circulating plasma proteins mediated such association.</p>}},
author = {{Lu, Xujia and Pei, Yalong and Geng, Yang and Fan, Yulong and Lu, Xinmei and Jiang, Lan and Borné, Yan and Ke, Chaofu}},
issn = {{1468-3296}},
language = {{eng}},
month = {{08}},
pages = {{1--10}},
publisher = {{BMJ Publishing Group}},
series = {{Thorax}},
title = {{Adherence to the EAT-Lancet diet, plasma proteomics and the risk of chronic obstructive pulmonary disease}},
url = {{http://dx.doi.org/10.1136/thorax-2025-223046}},
doi = {{10.1136/thorax-2025-223046}},
year = {{2025}},
}