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First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age

Lind, Alexander LU ; Lynch, Kristian F. LU ; Lundgren, Markus LU ; Lernmark, Åke LU ; Almgren, Peter LU ; Ramelius, Anita LU ; Puustinen, Leena; Hyöty, Heikki and Lundstig, Annika LU (2018) In Journal of Reproductive Immunology 127. p.1-6
Abstract

Background: Autoimmune (type 1) diabetes (T1D) is a frequent chronic disease in children and adolescents globally. Gestational enterovirus (EV) infections have been associated with an increased risk for T1D in the offspring. We test the hypothesis that EV infections during the first trimester were associated with beta cell autoantibodies in mothers of children who developed islet autoantibodies before 7 years of age. Materials and methods: Local registries were used to identify mothers to children born 2000–2007 who developed either beta cell autoantibodies or T1D during follow up. Serum samples from the first trimester were located in the Biobank. A total of 448 index mothers were identified and compared to 891 matched control mothers.... (More)

Background: Autoimmune (type 1) diabetes (T1D) is a frequent chronic disease in children and adolescents globally. Gestational enterovirus (EV) infections have been associated with an increased risk for T1D in the offspring. We test the hypothesis that EV infections during the first trimester were associated with beta cell autoantibodies in mothers of children who developed islet autoantibodies before 7 years of age. Materials and methods: Local registries were used to identify mothers to children born 2000–2007 who developed either beta cell autoantibodies or T1D during follow up. Serum samples from the first trimester were located in the Biobank. A total of 448 index mothers were identified and compared to 891 matched control mothers. EV-IgM was determined in a capture enzyme immunoassay. Beta cell autoantibodies were analyzed in standard radio binding assays. Results: The frequency of EV-IgM in index mothers was 20% (89/448), which did not differ from the control mothers 20% (175/891) (p = 0.922). Index mothers had multiple beta cell autoantibodies more often than control mothers (p = 0.037). Beta cell autoantibodies were increased during the November–April winter months in index compared to control mothers (p = 0.022). The observed difference was possibly explained by the months of February-April (p = 0.014). Concomitant EV-IgM and beta cell autoantibodies tended to be more common among index compared to control mothers (p = 0.039). Conclusion: EV-IgM during the first trimester may be associated with beta cell autoantibodies in mothers to children who developed either beta cell autoantibodies or T1D before 7 years of age.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Autoantibodies, Beta cell autoimmunity, Biobank, Capture enzyme Immunoassay, Childhood diabetes, Enterovirus, Epidemiology, EV IgM analysis, GAD65, Gestational infections, IA-2, Neutralization assay, Type 1 diabetes, Virus infections, ZnT8
in
Journal of Reproductive Immunology
volume
127
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85043763714
ISSN
0165-0378
DOI
10.1016/j.jri.2018.02.004
language
English
LU publication?
yes
id
4ab03b3d-0431-4b84-b4b9-ad467034bdc2
date added to LUP
2018-03-27 14:46:50
date last changed
2019-02-20 11:12:10
@article{4ab03b3d-0431-4b84-b4b9-ad467034bdc2,
  abstract     = {<p>Background: Autoimmune (type 1) diabetes (T1D) is a frequent chronic disease in children and adolescents globally. Gestational enterovirus (EV) infections have been associated with an increased risk for T1D in the offspring. We test the hypothesis that EV infections during the first trimester were associated with beta cell autoantibodies in mothers of children who developed islet autoantibodies before 7 years of age. Materials and methods: Local registries were used to identify mothers to children born 2000–2007 who developed either beta cell autoantibodies or T1D during follow up. Serum samples from the first trimester were located in the Biobank. A total of 448 index mothers were identified and compared to 891 matched control mothers. EV-IgM was determined in a capture enzyme immunoassay. Beta cell autoantibodies were analyzed in standard radio binding assays. Results: The frequency of EV-IgM in index mothers was 20% (89/448), which did not differ from the control mothers 20% (175/891) (p = 0.922). Index mothers had multiple beta cell autoantibodies more often than control mothers (p = 0.037). Beta cell autoantibodies were increased during the November–April winter months in index compared to control mothers (p = 0.022). The observed difference was possibly explained by the months of February-April (p = 0.014). Concomitant EV-IgM and beta cell autoantibodies tended to be more common among index compared to control mothers (p = 0.039). Conclusion: EV-IgM during the first trimester may be associated with beta cell autoantibodies in mothers to children who developed either beta cell autoantibodies or T1D before 7 years of age.</p>},
  author       = {Lind, Alexander and Lynch, Kristian F. and Lundgren, Markus and Lernmark, Åke and Almgren, Peter and Ramelius, Anita and Puustinen, Leena and Hyöty, Heikki and Lundstig, Annika},
  issn         = {0165-0378},
  keyword      = {Autoantibodies,Beta cell autoimmunity,Biobank,Capture enzyme Immunoassay,Childhood diabetes,Enterovirus,Epidemiology,EV IgM analysis,GAD65,Gestational infections,IA-2,Neutralization assay,Type 1 diabetes,Virus infections,ZnT8},
  language     = {eng},
  month        = {06},
  pages        = {1--6},
  publisher    = {Elsevier},
  series       = {Journal of Reproductive Immunology},
  title        = {First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age},
  url          = {http://dx.doi.org/10.1016/j.jri.2018.02.004},
  volume       = {127},
  year         = {2018},
}