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Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease.

Werner, Karin LU ; Elmståhl, Sölve LU ; Christensson, Anders LU and Pihlsgård, Mats LU (2014) In Age and Ageing 43(3). p.411-417
Abstract
Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes.Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population.Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931.Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or... (More)
Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes.Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population.Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931.Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both.Results: the median for plasma cystatin C was 0.93 mg/l (60-69 years old), 1.04 (70-79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR < 60 ml/min/1.73 m(2).Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR < 60 ml/min/1.73 m(2). (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Age and Ageing
volume
43
issue
3
pages
411 - 417
publisher
Oxford University Press
external identifiers
  • pmid:24321840
  • wos:000335770900023
  • scopus:84901981173
  • pmid:24321840
ISSN
1468-2834
DOI
10.1093/ageing/aft191
language
English
LU publication?
yes
id
4b10d1c1-fddf-47ad-b1b7-235a6fd2a49c (old id 4224952)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24321840?dopt=Abstract
date added to LUP
2016-04-01 10:01:20
date last changed
2022-01-25 19:00:34
@article{4b10d1c1-fddf-47ad-b1b7-235a6fd2a49c,
  abstract     = {{Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes.Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population.Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931.Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both.Results: the median for plasma cystatin C was 0.93 mg/l (60-69 years old), 1.04 (70-79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR &lt; 60 ml/min/1.73 m(2).Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR &lt; 60 ml/min/1.73 m(2).}},
  author       = {{Werner, Karin and Elmståhl, Sölve and Christensson, Anders and Pihlsgård, Mats}},
  issn         = {{1468-2834}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{411--417}},
  publisher    = {{Oxford University Press}},
  series       = {{Age and Ageing}},
  title        = {{Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease.}},
  url          = {{https://lup.lub.lu.se/search/files/1486362/4587334.pdf}},
  doi          = {{10.1093/ageing/aft191}},
  volume       = {{43}},
  year         = {{2014}},
}