Hypoxia inducible factor-2alpha in cancer.
(2007) In Cell Cycle 6(8). p.919-926- Abstract
- Poorly oxygenated ( hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels. Whether HIF-1 and HIF-2 have different roles in tumorigenesis is an open question and an issue we discuss. With focus on HIF-2, we summarize reported phenotypical changes of HIF genetic models and HIF expression patterns during normal development, in adult non - malignant tissues and in tumors. We further address the much - discussed subject of target gene preferences between HIF-1 and HIF-2, given that both transcription... (More)
- Poorly oxygenated ( hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels. Whether HIF-1 and HIF-2 have different roles in tumorigenesis is an open question and an issue we discuss. With focus on HIF-2, we summarize reported phenotypical changes of HIF genetic models and HIF expression patterns during normal development, in adult non - malignant tissues and in tumors. We further address the much - discussed subject of target gene preferences between HIF-1 and HIF-2, given that both transcription factors bind to the same DNA motif. Finally, we also discuss the observations that the oxygen - sensitive HIF-2 alpha subunit is accumulated and active under non - hypoxic conditions as exemplified by HIF-2 alpha expressing tumor macrophages and neuroblastoma cells located in seemingly well - vascularized tumor regions and how this phenomenon is related to tumor aggressiveness. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/167829
- author
- Löfstedt, Tobias LU ; Fredlund, Erik LU ; Holmquist Mengelbier, Linda LU ; Pietras, Alexander LU ; Ovenberger, Marie LU ; Poellinger, Lorenz and Påhlman, Sven LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- target genes, neuroblastoma, regulation, development, adaptation, hypoxia, cancer, hypoxia-inducible factor
- in
- Cell Cycle
- volume
- 6
- issue
- 8
- pages
- 919 - 926
- publisher
- Landes Bioscience
- external identifiers
-
- wos:000245948300010
- scopus:34247477207
- ISSN
- 1551-4005
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Medicine (013031200)
- id
- 4c854fdb-f32f-4633-b235-9fcb54aca5e2 (old id 167829)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17404509&dopt=Abstract
- http://www.landesbioscience.com/journals/cc/article/4133
- date added to LUP
- 2016-04-01 12:04:02
- date last changed
- 2022-04-21 01:58:20
@article{4c854fdb-f32f-4633-b235-9fcb54aca5e2, abstract = {{Poorly oxygenated ( hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels. Whether HIF-1 and HIF-2 have different roles in tumorigenesis is an open question and an issue we discuss. With focus on HIF-2, we summarize reported phenotypical changes of HIF genetic models and HIF expression patterns during normal development, in adult non - malignant tissues and in tumors. We further address the much - discussed subject of target gene preferences between HIF-1 and HIF-2, given that both transcription factors bind to the same DNA motif. Finally, we also discuss the observations that the oxygen - sensitive HIF-2 alpha subunit is accumulated and active under non - hypoxic conditions as exemplified by HIF-2 alpha expressing tumor macrophages and neuroblastoma cells located in seemingly well - vascularized tumor regions and how this phenomenon is related to tumor aggressiveness.}}, author = {{Löfstedt, Tobias and Fredlund, Erik and Holmquist Mengelbier, Linda and Pietras, Alexander and Ovenberger, Marie and Poellinger, Lorenz and Påhlman, Sven}}, issn = {{1551-4005}}, keywords = {{target genes; neuroblastoma; regulation; development; adaptation; hypoxia; cancer; hypoxia-inducible factor}}, language = {{eng}}, number = {{8}}, pages = {{919--926}}, publisher = {{Landes Bioscience}}, series = {{Cell Cycle}}, title = {{Hypoxia inducible factor-2alpha in cancer.}}, url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17404509&dopt=Abstract}}, volume = {{6}}, year = {{2007}}, }