Effects of oats on plasma cholesterol and lipoproteins in C57BL/6 mice are substrain specific.
(2010) In British Journal of Nutrition 103. p.513-521- Abstract
- Cholesterol-lowering effects of oats have been demonstrated in both animals and human subjects. However, the crucial properties of oat-containing diets that determine their health effects need to be further investigated to optimise their use. A mouse model would be a valuable tool, but few such studies have been published to date. We investigated the effects of oat bran on plasma cholesterol and lipoproteins in two substrains of C57BL/6 mice. Western diet was made atherogenic by the addition of 0.8 % cholesterol and 0.1 % cholic acid. After 4 weeks on atherogenic diet, total plasma cholesterol had increased from 1.86-2.53 to 3.77-4.40 mmol/l. In C57BL/6NCrl mice, inclusion of 27 and 40 % oat bran reduced total plasma cholesterol by 19 and... (More)
- Cholesterol-lowering effects of oats have been demonstrated in both animals and human subjects. However, the crucial properties of oat-containing diets that determine their health effects need to be further investigated to optimise their use. A mouse model would be a valuable tool, but few such studies have been published to date. We investigated the effects of oat bran on plasma cholesterol and lipoproteins in two substrains of C57BL/6 mice. Western diet was made atherogenic by the addition of 0.8 % cholesterol and 0.1 % cholic acid. After 4 weeks on atherogenic diet, total plasma cholesterol had increased from 1.86-2.53 to 3.77-4.40 mmol/l. In C57BL/6NCrl mice, inclusion of 27 and 40 % oat bran reduced total plasma cholesterol by 19 and 24 %, respectively, reduced the shift from HDL to LDL+VLDL and caused increased faecal cholesterol excretion. There was no effect of oat bran on plasma levels of the inflammatory markers fibrinogen, serum amyloid A or TNF-alpha. Contrary to findings in C57BL/6NCrl mice, there was no sustained effect of oat bran (27 or 40 %) on plasma cholesterol in C57BL/6JBomTac mice after 4 weeks of feeding. Thus, C57BL/6NCrl mice fed an atherogenic diet are a good model for studies of physiological effects of oats, whereas a substrain derived from C57BL/6J, raised in a different breeding environment and likely possessing functional genetic differences from C57BL/6N, is considerably less responsive to oats. The present finding that two substrains of mice respond differently to oats is of practical value, but can also help to elucidate mechanisms of the cholesterol-lowering effect of oats. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1500207
- author
- Andersson, Kristina E LU ; Immerstrand, Tina LU ; Swärd, Karl LU ; Bergenståhl, Björn LU ; Lindholm, Marie LU ; Öste, Rickard LU and Hellstrand, Per LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Nutrition
- volume
- 103
- pages
- 513 - 521
- publisher
- Cambridge University Press
- external identifiers
-
- wos:000274804900007
- pmid:19840420
- scopus:77649198133
- pmid:19840420
- ISSN
- 1475-2662
- DOI
- 10.1017/S000711450999211X
- project
- ANTIDIABETIC FOOD CENTRE
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Vascular Physiology (013212034), Experimental Cardiovascular Research Unit (013242110), Food Technology (011001017), Applied Nutrition and Food Chemistry (011001300)
- id
- 4ca35c79-2bc5-42e4-9bdb-bebd4c1a094a (old id 1500207)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19840420?dopt=Abstract
- date added to LUP
- 2016-04-04 07:07:36
- date last changed
- 2023-11-29 16:04:10
@article{4ca35c79-2bc5-42e4-9bdb-bebd4c1a094a,
abstract = {{Cholesterol-lowering effects of oats have been demonstrated in both animals and human subjects. However, the crucial properties of oat-containing diets that determine their health effects need to be further investigated to optimise their use. A mouse model would be a valuable tool, but few such studies have been published to date. We investigated the effects of oat bran on plasma cholesterol and lipoproteins in two substrains of C57BL/6 mice. Western diet was made atherogenic by the addition of 0.8 % cholesterol and 0.1 % cholic acid. After 4 weeks on atherogenic diet, total plasma cholesterol had increased from 1.86-2.53 to 3.77-4.40 mmol/l. In C57BL/6NCrl mice, inclusion of 27 and 40 % oat bran reduced total plasma cholesterol by 19 and 24 %, respectively, reduced the shift from HDL to LDL+VLDL and caused increased faecal cholesterol excretion. There was no effect of oat bran on plasma levels of the inflammatory markers fibrinogen, serum amyloid A or TNF-alpha. Contrary to findings in C57BL/6NCrl mice, there was no sustained effect of oat bran (27 or 40 %) on plasma cholesterol in C57BL/6JBomTac mice after 4 weeks of feeding. Thus, C57BL/6NCrl mice fed an atherogenic diet are a good model for studies of physiological effects of oats, whereas a substrain derived from C57BL/6J, raised in a different breeding environment and likely possessing functional genetic differences from C57BL/6N, is considerably less responsive to oats. The present finding that two substrains of mice respond differently to oats is of practical value, but can also help to elucidate mechanisms of the cholesterol-lowering effect of oats.}},
author = {{Andersson, Kristina E and Immerstrand, Tina and Swärd, Karl and Bergenståhl, Björn and Lindholm, Marie and Öste, Rickard and Hellstrand, Per}},
issn = {{1475-2662}},
language = {{eng}},
pages = {{513--521}},
publisher = {{Cambridge University Press}},
series = {{British Journal of Nutrition}},
title = {{Effects of oats on plasma cholesterol and lipoproteins in C57BL/6 mice are substrain specific.}},
url = {{http://dx.doi.org/10.1017/S000711450999211X}},
doi = {{10.1017/S000711450999211X}},
volume = {{103}},
year = {{2010}},
}